NIPP1 (PPP1R8) (NM_014110) Human Mass Spec Standard

SKU PH318843

PPP1R8 MS Standard C13 and N15-labeled recombinant protein (NP_054829)

Product Data

• Tag: C-Myc/DDK
• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: [RC218843]
• Predicted MW: 38.5 kDa
• Protein Sequence:
  Protein Sequence

  >RC218843 protein sequence; Red=Cloning site Green=Tags(s); ; MAAAANSGSSLPLFDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRV; HAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGD; EKMGGEDDELKGLLGLPEEETELDNLTEFITAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEII; NPEDVDPSVGRFRNMVQTAVVPVKKKRVEGPGSLGLEESGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHG; IHGTALIGGLPMPYPNLAPDVDLTPVVPSAVNMNPAPNPAVYNPEAVNEPKKKKYAKEAWPGKKPTPSLL; I; ; TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Labeling Method: Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
• Buffer: 25 mM Tris-HCl, 100 mM glycine, pH 7.3
• Storage: Store at -80°C. Avoid repeated freeze-thaw cycles.
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_054829
• RefSeq Size: 2377
• RefSeq ORF: 1053
• Synonyms: ARD-1; ARD1; NIPP-1; NIPP1; PRO2047
• Locus ID: 5511
• UniProt ID: Q12972
• Cytogenetics: 1p35.3
• Summary: This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome, Transcription Factors