PAPP A (PAPPA) (NM_002581) Human Mass Spec Standard
$3,360.00
3 Weeks*
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC209767 |
| Predicted MW | 181.4 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002572 |
| RefSeq Size | 11025 |
| RefSeq ORF | 4881 |
| Synonyms | ASBABP2; DIPLA1; IGFBP-4ase; PAPA; PAPP-A; PAPPA1 |
| Locus ID | 5069 |
| UniProt ID | Q13219 |
| Cytogenetics | 9q33.1 |
| Summary | This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. provided by RefSeq, Aug 2017 |
| Protein Families | Druggable Genome, Protease, Secreted Protein |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "PAPP A" proteins (1)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TP309767 | Purified recombinant protein of Homo sapiens pregnancy-associated plasma protein A, pappalysin 1 (PAPPA), 20 µg | 20 ug |
$867.00
|
|
Citations
MiR-490-3p modulates the proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A
Sun, Chen, Cao et al
Cardiovasc. Res. (2013)
Sun, Chen, Cao et al
Cardiovasc. Res. (2013)
Cited by 79
AI Summary: In this study, OriGene's PAPP-A siRNA and PAPP-A expression vector were used to manipulate PAPP-A levels in vascular smooth muscle cells, enabling the authors to investigate the regulatory role of miR-490-3p in ox-LDL-induced cell proliferation.
Snippet: 2.2 Vectors, cell culture, and treatment. The siRNA and expression vector of PAPP-A were purchased from Origene. The mutation (MUT) and wild-type (WT) vector of miR-490-3p sponge were constructed by GenePharma (Shanghai, China).
Showing 1-1 of 1 papers.
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