CCDC25 (NM_018246) Human Mass Spec Standard

SKU
PH309050
CCDC25 MS Standard C13 and N15-labeled recombinant protein (NP_060716)
  $3,360.00
3 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC209050
Predicted MW 24.3 kDa
Protein Sequence
Protein Sequence
>RC209050 representing NM_018246
Red=Cloning site Green=Tags(s)

MVFYFTSSSVNSSAYTIYMGKDKYENEDLIKHGWPEDIWFHVDKLSSAHVYLRLHKGENIEDIPKEVLMD
CAHLVKANSIQGCKMNNVNVVYTPWSNLKKTADMDVGQIGFHRQKDVKIVTVEKKVNEILNRLEKTKVER
FPDLAAEKECRDREERNEKKAQIQEMKKREKEEMKKKREMDELRSYSSLMKVENMSSNQDGNDSDEFM

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_060716
RefSeq Size 3653
RefSeq ORF 624
Locus ID 55246
UniProt ID Q86WR0
Cytogenetics 8p21.1
Summary Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174).UniProtKB/Swiss-Prot Function
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Other "CCDC25" proteins (3)
SKU Description Size Price
LC413187 Lyophilized CCDC25 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY413187 Transient overexpression lysate of coiled-coil domain containing 25 (CCDC25) (as WB positive control) 100 ug
$436.00
TP309050 Recombinant protein of human coiled-coil domain containing 25 (CCDC25), 20 µg 20 ug
$867.00

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