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IMPACT (NM_018439) Human Mass Spec Standard

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SKU
PH304631
IMPACT MS Standard C13 and N15-labeled recombinant protein (NP_060909)
Size:
10 ug
  $3,360.00
3 Weeks*
Bulk/Customize

Frequently Bought Together (1)

LY412993 Transient overexpression lysate of Impact homolog (mouse) (IMPACT) (as WB positive control) 100 ug
$436.00

Other products for "IMPACT or NM_018439"

Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC204631
Predicted MW 36.5 kDa
Protein Sequence
Protein Sequence
>RC204631 protein sequence
Red=Cloning site Green=Tags(s)

MAEGDAGSDQRQNEEIEAMAAIYGEEWCVIDDCAKIFCIRISDDIDDPKWTLCLQVMLPNEYPGTAPPIY
QLNAPWLKGQERADLSNSLEEIYIQNIGESILYLWVEKIRDVLIQKSQMTEPGPDVKKKTEEEDVECEDD
LILACQPESSVKALDFDISETRTEVEVEELPPIDHGIPITDRRSTFQAHLAPVVCPKQVKMVLSKLYENK
KIASATHNIYAYRIYCEDKQTFLQDCEDDGETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPDRFKH
INNCARNILVEKNYTNSPEESSKALGKNKKVRKDKKRNEH

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_060909
RefSeq Size 3764
RefSeq ORF 960
Synonyms RWDD5
Locus ID 55364
UniProt ID Q9P2X3
Cytogenetics 18q11.2
Summary Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.UniProtKB/Swiss-Prot Function
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Other "IMPACT" proteins (3)
SKU Description Size Price
LC412993 Lyophilized IMPACT HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY412993 Transient overexpression lysate of Impact homolog (mouse) (IMPACT) (as WB positive control) 100 ug
$436.00
TP304631 Recombinant protein of human Impact homolog (mouse) (IMPACT), 20 µg 20 ug
$737.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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