OAS1 (NM_002534) Human Mass Spec Standard

CAT#: PH300696

OAS1 MS Standard C13 and N15-labeled recombinant protein (NP_002525)

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USD 1,995.00

3 Weeks

    • 10 ug

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Product Data
Description OAS1 MS Standard C13 and N15-labeled recombinant protein (NP_002525)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC200696
Predicted MW 41.6 kDa
Protein Sequence
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_002525
RefSeq Size 1470
RefSeq ORF 1092
Synonyms IFI-4; OIAS; OIASI
Locus ID 4938
Cytogenetics 12q24.13
Summary This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.