SCUBE2 (NM_020974) Human Tagged ORF Clone Lentiviral Particle

SKU RC224136L3V

Lenti ORF particles, SCUBE2 (Myc-DDK-tagged)-Human signal peptide, CUB domain, EGF-like 2 (SCUBE2), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: SCUBE2
• Synonyms: CEGB1; CEGF1; CEGP1; scube/You
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC224136).
• ACCN: NM_020974
• ORF Size: 2997 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_020974.1, NP_066025.1
• RefSeq Size: 3737 bp
• RefSeq ORF: 2916 bp
• Locus ID: 57758
• UniProt ID: Q9NQ36
• Cytogenetics: 11p15.4
• Domains: CUB, EGF, EGF_CA
• Protein Families: Transmembrane
• MW: 106.6 kDa
• Summary: Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).[UniProtKB/Swiss-Prot Function]