GRIA4 (NM_000829) Human Tagged ORF Clone Lentiviral Particle
- LentiORF®
-
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone Lentiviral Particle |
|---|---|
| Tag | Myc-DDK |
| Target Symbol | GRIA4 |
| Synonyms | GluA4; GluA4-ATD; GLUR4; GLUR4C; GLURD; NEDSGA |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| Mammalian Cell Selection | Puromycin |
| Sequence Data | |
| ACCN | NM_000829 |
| ORF Size | 2706 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NM_000829.3, NP_000820.3 |
| RefSeq Size | 5508 bp |
| RefSeq ORF | 2709 bp |
| Locus ID | 2893 |
| UniProt ID | P48058 |
| Cytogenetics | 11q22.3 |
| Domains | ANF_receptor, lig_chan |
| Protein Families | Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane |
| Protein Pathways | Neuroactive ligand-receptor interaction |
| MW | 100.8 kDa |
| Summary | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. provided by RefSeq, Jul 2008 |
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