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BCR (NM_004327) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC211635L2V
Lenti ORF particles, BCR (mGFP-tagged)-Human breakpoint cluster region (BCR), transcript variant 1, 200ul, >10^7 TU/mL
  $1,767.00
5 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol BCR
Synonyms ALL; BCR1; CML; D22S11; D22S662; PHL
Vector pLenti-C-mGFP
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC211635).
ACCN NM_004327
ORF Size 3813 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_004327.3
RefSeq Size 4739 bp
RefSeq ORF 3816 bp
Locus ID 613
UniProt ID P11274
Cytogenetics 22q11.23
Domains C2, PH, RhoGAP, RhoGEF
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Chronic myeloid leukemia, Pathways in cancer
MW 142.6 kDa
Summary A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.provided by RefSeq, Jan 2020
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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