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HDAC6 (NM_006044) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC209649L4V
Lenti ORF particles, HDAC6 (mGFP-tagged) - Human histone deacetylase 6 (HDAC6), 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
mGFP w/ Puro DDK mGFP DDK w/ Puro
  $2,136.00
2 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol HDAC6
Synonyms CPBHM; HD6; JM21; PPP1R90
Vector pLenti-C-mGFP-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC209649).
ACCN NM_006044
ORF Size 3645 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_006044.2
RefSeq Size 4099 bp
RefSeq ORF 3648 bp
Locus ID 10013
UniProt ID Q9UBN7, A0A024QZ26, Q9NSW6
Cytogenetics Xp11.23
Domains Hist_deacetyl, zf-UBP
Protein Families Druggable Genome, Transcription Factors
MW 131.2 kDa
Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. provided by RefSeq, Jul 2008
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Documents
Resources

file-alt Citations

Rational cotargeting of HDAC6 and BET proteins yields synergistic antimyeloma activity
Carew, Espitia, Zhao et al
Blood Adv (2019) 3 (8), 1318-1329 DOI: 10.1182/bloodadvances.2018026484
AI Summary: OriGene contributed lenti–open reading frame particles encoding HDAC6, which were used to generate HDAC6-overexpressing multiple myeloma cells to investigate the role of HDAC6 in synergistic antimyeloma activity when cotargeting HDAC6 and BET proteins.
Snippet: knockdown were confirmed by immunoblotting. LENTIVIRAL OVEREXPRESSION OF HDAC6 RPMI-8226 MM cells were infected with lenti–open reading frame particles encoding _HDAC6_ or a nontargeted control (Origene, Rockville, MD) using 5 µg/mL polybrene. Infected cells were selected with constant culture in 1 μg/mL puromycin. HDAC6 overexpression was confirmed by immunoblotting. QUANTITATIVE RT-PCR
Showing 1-1 of 1 papers.
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