Munc 13 4 (UNC13D) (NM_199242) Human Tagged ORF Clone Lentiviral Particle

SKU RC209141L4V

Lenti ORF particles, UNC13D (mGFP-tagged) - Human unc-13 homolog D (C. elegans) (UNC13D), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: Munc 13 4
• Synonyms: FHL3; HLH3; HPLH3; Munc13-4
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC209141).
• ACCN: NM_199242
• ORF Size: 3270 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_199242.2
• RefSeq Size: 4406 bp
• RefSeq ORF: 3273 bp
• Locus ID: 201294
• UniProt ID: Q70J99
• Cytogenetics: 17q25.1
• MW: 123.3 kDa
• Summary: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]