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DDR2 (NM_001014796) Human Tagged ORF Clone Lentiviral Particle

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SKU
RC208745L3V
Lenti ORF particles, DDR2 (Myc-DDK tagged) - Human discoidin domain receptor tyrosine kinase 2 (DDR2), transcript variant 1, 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
DDK w/ Puro mGFP w/ Puro
  $1,333.00
2 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol DDR2
Synonyms MIG20a; NTRKR3; TKT; TYRO10; WRCN
Vector pLenti-C-Myc-DDK-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC208745).
ACCN NM_001014796
ORF Size 2565 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_001014796.1
RefSeq Size 3252 bp
RefSeq ORF 2568 bp
Locus ID 4921
UniProt ID Q16832
Cytogenetics 1q23.3
Protein Families Druggable Genome, Protein Kinase, Transmembrane
MW 96.7 kDa
Summary This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. provided by RefSeq, Aug 2017
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Documents
Resources

file-alt Citations

Clustering, Spatial Distribution and Phosphorylation of Discoidin Domain Receptors 1 and 2 in Response to Soluble Collagen Type I
Yeung, Shanker, Sohail et al
J. Mol. Biol. (2018) 431 (2), 368-390 DOI: 10.1016/j.jmb.2018.11.015
AI Summary: OriGene contributed to this study by providing the human DDR2-GFP expression vector, which was used to express full-length DDR2 in cells for analysis of receptor clustering, spatial distribution, and phosphorylation.
Snippet: … For expression of full-length DDRs in cells, we purchased an expression vector containing the human DDR2 cDNA tagged with green fluorescent protein (GFP) at the C-terminus from Origene (Rockville, MD). … For expression of full-length DDRs in cells, we purchased an expression vector containing the human DDR2 cDNA tagged with GFP at the C-terminus from Origene (Rockville, MD). …
Showing 1-1 of 1 papers.
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