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IFI16 (NM_005531) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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RC202193L2V
Lenti ORF particles, IFI16 (mGFP-tagged) - Human interferon, gamma-inducible protein 16 (IFI16), transcript variant 2, 200ul, >10^7 TU/mL
  $1,551.00
3 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol IFI16
Synonyms IFNGIP1; PYHIN2
Vector pLenti-C-mGFP
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC202193).
ACCN NM_005531
ORF Size 2187 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_005531.1
RefSeq Size 2709 bp
RefSeq ORF 2190 bp
Locus ID 3428
UniProt ID Q16666
Cytogenetics 1q23.1
Domains HIN, PAAD_DAPIN
Protein Families Transcription Factors
MW 82 kDa
Summary This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Apr 2011
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Documents
Resources

file-alt Citations

Interferon-γ inducible factor 16 (IFI16) restricts adeno-associated virus type 2 (AAV2) transduction in an immune-modulatory independent way
Sutter, Tobler, Seyffert et al
J Virol (2024)
Cited by 6
AI Summary: OriGene contributed lentiviral vectors expressing GFP (TR30021V) and IFI16 fused to monomeric GFP (RC202193L2V), which were used to study the role of IFI16 in restricting AAV2 transduction in human fibroblasts.
Snippet: J. Neidhardt, University of Zurich, Switzerland), respectively, and purified by an iodixanol density gradient. Titers of genome-containing particles were determined by quantitative PCR (qPCR) (47). Lentiviral vectors expressing GFP (TR30021V) or IFI16 fused to monomeric GFP (RC202193L2V) were obtained from OriGene (Rockville, USA)
The interferon-ɣ inducible factor 16 (IFI16) restricts adeno-associated virus serotype 2 (AAV2) transduction in an immune-modulatory independent way
Sutter, Tobler, Seyffert et al
bioRxiv (2024)
Snippet: We determined the transcription profile of AAV2-infected primary human fibroblasts. Subsequent analysis revealed that cells respond to AAV infection through changes in;fused to monomeric GFP (RC202193L2V) were obtained from OriGene (Rockville, 556 USA). …
Showing 1-2 of 2 papers.
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