Flt3 (NM_010229) Mouse Tagged ORF Clone Lentiviral Particle

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MR223373L4V
Lenti ORF particles, Flt3 (GFP-tagged) - Mouse FMS-like tyrosine kinase 3 (Flt3), 200ul, >10^7 TU/mL
  $1,923.00
5 Weeks*
Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol Flt3
Synonyms B230315G04; CD135; Flk-2; Flk2; Flt-3; Ly72; wmfl
Vector pLenti-C-mGFP-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(MR223373).
ACCN NM_010229
ORF Size 3000 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_010229.2, NP_034359.2
RefSeq Size 3664 bp
RefSeq ORF 3003 bp
Locus ID 14255
UniProt ID Q00342
Cytogenetics 5 G3
Summary Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.UniProtKB/Swiss-Prot Function
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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