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Nlrp1b (NM_001162414) Mouse Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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MR215349L4V
Lenti ORF particles, Nlrp1b (GFP-tagged) - Mouse NLR family, pyrin domain containing 1B (Nlrp1b), transcript variant 3, 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
tGFP DDK
Lentiviral Particles:
mGFP w/ Puro DDK w/ Puro
  $2,086.00
5 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol Nlrp1b
Synonyms ENSMUSG00000070390; Nalp1b; OTTMUSG00000006087; OTTMUSG00000006089
Vector pLenti-C-mGFP-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(MR215349).
ACCN NM_001162414
ORF Size 3531 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_001162414.1, NP_001155886.1
RefSeq Size 4131 bp
RefSeq ORF 3534 bp
Locus ID 637515
UniProt ID A1Z198
Cytogenetics 11 B4
Summary As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (By similarity). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Might be activated by Toxoplasma gondii, although at a lower extent than allele 1 (PubMed:24218483). Contrary to Nlrp1b allele 1, allele 2 is not activated by Bacillus anthracis lethal toxin (PubMed:16429160, PubMed:21170303, PubMed:24492532).UniProtKB/Swiss-Prot Function
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