Thbs1 (NM_011580) Mouse Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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MR211744L3V
Lenti ORF particles, Thbs1 (Myc-DDK-tagged) - Mouse thrombospondin 1 (Thbs1), 200ul, >10^7 TU/mL
  $2,079.00
3 Weeks*
Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol Thbs1
Synonyms tbs; tbsp1; Thbs-; Thbs-1; TS; TSP; TSP-1; TSP1
Vector pLenti-C-Myc-DDK-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(MR211744).
ACCN NM_011580
ORF Size 3513 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_011580.3
RefSeq Size 5802 bp
RefSeq ORF 3516 bp
Locus ID 21825
Cytogenetics 2 59.34 cM
Summary The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Sep 2015
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Documents
Resources

file-alt Citations

Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme
Jacquemin, Wurmser, Huyghe et al
Elife (2022) 11 DOI: 10.7554/eLife.76541
AI Summary: OriGene’s LentiThbs1Tg (lentiORF-expressing mouse Thbs1, OriGene# MR211744L3V) was used in this study to overexpress Thbs1 and investigate its role in mediating paracrine signalling and regenerative transcriptional reprogramming in intestinal epithelial cells.
Snippet: … These findings indicate that WT organoids in the presence of tumour-secreted factors, including THBS1, switch their transcriptional programme from a Wnt-dependent homeostatic to a Wnt-inde;LentiThbs1Tg is a lentiORF-expressing mouse Thbs1 (NM_011580) –myc-DKK (Origene# MR211744L3V). …
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Showing 1-1 of 1 papers.
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