P2RX7 (NM_002562) Human Untagged Clone
SKU
SC310230
P2RX7 (untagged)-Human purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), transcript variant 1
$555.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | P2RX7 |
| Synonyms | P2X7 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_002562 |
| Insert Size | 2100 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | There is 2 nucleotide difference between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substituion of 2 aa. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002562.4, NP_002553.2 |
| RefSeq Size | 3155 bp |
| RefSeq ORF | 1788 bp |
| Locus ID | 5027 |
| UniProt ID | Q99572 |
| Cytogenetics | 12q24.31 |
| Domains | P2X_receptor |
| Protein Families | Druggable Genome, Ion Channels: ATP Receptors, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
| Summary | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. provided by RefSeq, Jul 2010 Transcript Variant: This variant (1) encodes a functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002562" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC222143 | P2RX7 (Myc-DDK-tagged)-Human purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), transcript variant 1 | 10 ug |
$554.00
|
|
| RC222143L1 | Lenti ORF clone of Human purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), transcript variant 1, Myc-DDK-tagged | 10 ug |
$854.00
|
|
| RC222143L2 | Lenti ORF clone of Human purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), transcript variant 1, mGFP tagged | 10 ug |
$854.00
|
|
| RC222143L3 | Lenti ORF clone of Human purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), transcript variant 1, Myc-DDK-tagged | 10 ug |
$854.00
|
|
| RC222143L4 | Lenti ORF clone of Human purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), transcript variant 1, mGFP tagged | 10 ug |
$854.00
|
|
| RG222143 | P2RX7 (tGFP-tagged) - Human purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), transcript variant 1 | 10 ug |
$489.00
$754.00
|
|
Citations
Lidocaine Preferentially Inhibits the Function of Purinergic P2X7 Receptors Expressed in Xenopus Oocytes
Okura, Horishita, Ueno et al
Anesth. Analg. (2015) 120 (3), 597-605 DOI: 10.1213/ANE.0000000000000585
Okura, Horishita, Ueno et al
Anesth. Analg. (2015) 120 (3), 597-605 DOI: 10.1213/ANE.0000000000000585
AI Summary: OriGene contributed to this study by providing the human P2X3, P2X4, and P2X7 receptor cDNA plasmids used to express these receptors in Xenopus oocytes for functional analysis.
Snippet: All plasmids including human P2X3, P2X4, and P2X7 receptor complementary DNA (cDNA) were purchased from OriGene Technologies (Rockville, MD)
Showing 1-1 of 1 papers.
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