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PML Protein (PML) (NM_033249) Human Untagged Clone

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SKU
SC310060
PML (untagged)-Human promyelocytic leukemia (PML), transcript variant 10
  $545.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol PML Protein
Synonyms MYL; PP8675; RNF71; TRIM19
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF sequence for NM_033249 edited
AGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGA
ATTCGGCACGAGGCGAGAATCGAAACTAAGCTGGGGTCCATGGAGCCTGCACCCGCCCGA
TCTCCGAGGCCCCAGCAGGACCCCGCCCGGCCCCAGGAGCCCACCATGCCTCCCCCCGAG
ACCCCCTCTGAAGGCCGCCAGCCCAGCCCCAGCCCCAGCCCTACAGAGCGAGCCCCCGCT
TCGGAGGAGGAGTTCCAGTTTCTGCGCTGCCAGCAATGCCAGGCGGAAGCCAAGTGCCCG
AAGCTGCTGCCTTGTCTGCACACGCTGTGCTCAGGATGCCTGGAGGCGTCGGGCATGCAG
TGCCCCATCTGCCAGGCGCCCTGGCCCCTAGGTGCAGACACACCCGCCCTGGATAACGTC
TTTTTCGAGAGTCTGCAGCGGCGCCTGTCGGTGTACCGGCAGATTGTGGATGCGCAGGCT
GTGTGCACCCGCTGCAAAGAGTCGGCCGACTTCTGGTGCTTTGAGTGCGAGCAGCTCCTC
TGCGCCAAGTGCTTCGAGGCACACCAGTGGTTCCTCAAGCACGAGGCCCGGCCCCTAGCA
GAGCTGCGCAACCAGTCGGTGCGTGAGTTCCTGGACGGCACCCGCAAGACCAACAACATC
TTCTGCTCCAACCCCAACCACCGCACCCCTACGCTGACCAGCATCTACTGCCGAGGATGT
TCCAAGCCGCTGTGCTGCTCGTGCGCGCTCCTTGACAGCAGCCACAGTGAGCTCAAGTGC
GACATCAGCGCAGAGATCCAGCAGCGACAGGAGGAGCTGGACGCCATGACGCAGGCGCTG
CAGGAGCAGGATAGTGCCTTTGGCGCGGTTCACGCGCAGATGCACGCGGCCGTCGGCCAG
CTGGGCCGCGCGCGTGCCGAGACCGAGGAGCTGATCCGCGAGCGCGTGCGCCAGGTGGTA
GCTCACGTGCGGGCTCAGGAGCGCGAGCTGCTGGAGGCTGTGGACGCGCGGTACCAGCGC
GACTACGAGGAGATGGCCAGTCGGCTGGGCCGCCTGGATGCTGTGCTGCAGCGCATCCGC
ACGGGCAGCGCGCTGGTGCAGAGGATGAAGTGCTACGCCTCGGACCAGGAGGTGCTGGAC
ATGCACGGTTTCCTGCGCCAGGCGCTCTGCCGCCTGCGCCAGGAGGAGCCCCAGAGCCTG
CAAGCTGCCGTGCGCACCGATGGCTTCGACGAGTTCAAGGTGCGCCTGCAGGACCTCAGC
TCTTGCATCACCCAGGGGAAAGATGCAGCTGTATCCAAGAAAGCCAGCCCAGAGGCTGCC
AGCACTCCCAGGGACCCTATTGACGTTGACCTGGATGTCTCCAATACAACGACAGCCCAG
AAGAGGAAGTGCAGCCAGACCCAGTGCCCCAGGAAGGTCATCAAGATGGAGTCTGAGGAG
GGGAAGGAGGCAAGGTTGGCTCGGAGCTCCCCGGAGCAGCCCAGGCCCAGCACCTCCAAG
GCAGTCTCACCACCCCACCTGGATGGACCGCCTAGCCCCAGGAGCCCCGTCATAGGAAGT
GAGGTCTTCCTGCCCAACAGCAACCACGTGGCCAGTGGCGCCGGGGAGGCAGAGGAACGC
GTTGTGGTGATCAGCAGCTCGGAAGACTCAGATGCCGAAAACTCGTCCTCCCGAGAGCTG
GATGACAGCAGCAGTGAGTCCAGTGACCTCCAGCTGGAAGGCCCCAGCACCCTCAGGGTC
CTGGACGAGAACCTTGCTGACCCCCAAGCAGAAGACAGACCTCTGGTTTTCTTTGACCTC
AAGATTGACAATGAAACCCAGAAGATTAGCCAGCTGGCTGCGGTGAACCGGGAAAGCAAG
TTCCGCGTGGTCATCCAGCCTGAAGCCCTCTTCAGCATCTACTCCAAGGCCGTGTCCCTG
GAGGTGGGGCTGCAGCACTTCCTCAGCTTTCTGAGCTCCATGCGCCGCCCTATCTTGGCC
TGCTACAAGCTGTGGGGGCCTGGCCTCCCAAACTTCTTCCGGGCCCTGGAGGACATTAAC
AGGCTGTGGGAATTCCAGGAGGCCATCTCGGGCTTCCTGGCTGCCCTGCCTCTCATCCGG
GAGCGTGTGCCCGGGGCCAGCAGCTTCAAACTCAAGAACCTGGCCCAGACCTACCTGGCG
AGAAACATGAGCGAGCGCAGCGCCATGGCTGCCGTGCTGGCCATGCGTGACCTGTGCCGC
CTCCTCGAGGTCTCCCCGGGCCCCCAGCTGGCCCAGCATGTCTACCCCTTCAGTAGCCTG
CAGTGCTTTGCCTCCCTGCAGCCCCTGGTGCAGGCAGCTGTGCTGCCCCGGGCTGAGGCC
CGCCTCCTGGCCCTACACAACGTGAGCTTCATGGAGCTGCTGAGTGCACACCGCCGTGAC
CGGCAGGGGGGCCTGAAGAAGTACAGCCGCTATCTAAGCCTGCAGACCACCACGTTGCCC
CCTGCCCAGCCTGCTTTCAACCTGCAGGCTCTGGGCACCTACTTTGAAGGCCTGTTGGAG
GGTCCGGCGCTGGCACGGGCAGAAGGAGTCTCCACCCCACTTGCTGGCCGTGGCTTGGCA
GAGAGGGCCTCCCAGCAGAGCTGAGAGGAGGGGGTGACCAGCTTGGAGTCTCTGGTGGGC
AGAGAGGGATGGGGTCCCTGAGCCAGGCCCCACCCATCACAGCATTCCCAGGTCCTGGTA
CCCA
5' Read Nucleotide Sequence
>OriGene 5' read for NM_033249 unedited
AGAAATTTGTAATACGACTCACTATAGGGGCGGCCGCGAATCGGCACGAGGCGAGAATCG
AAACTAAGCTGGGGTCCATGGAGCCTGCACCCGCCCGATCTCCGAGGCCCCAGCAGGACC
CCGCCCGGCCCCAGGAGCCCACCATGCCTCCCCCCGAGACCCCCTCTGAAGGCCGCCAGC
CCAGCCCCAGCCCCAGCCCTACAGAGCGAGCCCCCGCTTCGGAGGAGGAGTTCCAGTTTC
TGCGCTGCCAGCAATGCCAGGCGGAAGCCAAGTGCCCGAAGCTGCTGCCTTGTCTGCACA
CGCTGTGCTCAGGATGCCTGGAGGCGTCGGGCATGCAGTGCCCCATCTGCCAGGCGCCCT
GGCCCCTAGGTGCAGACACACCCGCCCTGGATAACGTCTTTTTCGAGAGTCTGCAGCGGC
GCCTGTCGGTGTACCGGCAGATTGTGGATGCGCAGGCTGTGTGCACCCGCTGCAAAGAGT
CGGCCGACTTCTGGTGCTTTGAGTGCGAGCAGCTCCTCTGCGCCAAGTGCTTCGAGGCAC
ACCAGTGGTTCCTCAAGCACGAGGCCCGGCCCCTAGCAGAGCTGCGCAACCAGTCGGTGC
GTGAGTTCCTGGACGGCACCCGCAAGACCAACAACATCTTCTGCTCCAACCCCAACCACC
GCACCCCTACGCTGACCAGCATCTACTGCCGAGGATGTTCCAAGCCGCTGTGCTGCTCGT
GCGCGCTCCTTGACAGCAGCCACAGTGAGCTCAAGTGCGACATCAGCGCAGAGATCCAGC
AGCGACAGGAAGAGCTGGACGCCCATGACGCAGCGCTGCANGAGCANGATAGTGCCTTTG
GCGCGGTNACGCGCAAATGCACGCGNCGTCG
Restriction Sites NotI-NotI |
ACCN NM_033249
Insert Size 3900 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_033249.2, NP_150252.1
RefSeq Size 2110 bp
RefSeq ORF 1758 bp
Locus ID 5371
UniProt ID P29590
Cytogenetics 15q24.1
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. provided by RefSeq, Jul 2008
Transcript Variant: This variant (10) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (10, also known as PML-4A, PML-IVA and TRIM19lambda) has a distinct C-terminus and is shorter than isoform 1.
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Documents
Resources
"NM_033249" in other vectors (4)
SKU Description Size Price
RC224728 PML (Myc-DDK-tagged)-Human promyelocytic leukemia (PML), transcript variant 10 10 ug
$599.00
RC224728L3 Lenti-ORF clone of PML (Myc-DDK-tagged)-Human promyelocytic leukemia (PML), transcript variant 10 10 ug
$899.00
RC224728L4 Lenti-ORF clone of PML (mGFP-tagged)-Human promyelocytic leukemia (PML), transcript variant 10 10 ug
$899.00
RG224728 PML (tGFP-tagged) - Human promyelocytic leukemia (PML), transcript variant 10 10 ug
$789.00 $799.00

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