Parathyroid hormone related protein (PTHLH) (NM_198966) Human Untagged Clone
$300.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | Parathyroid hormone related protein |
| Synonyms | BDE2; HHM; PLP; PTHR; PTHRP |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_198966 |
| Insert Size | 1300 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_198966.1, NP_945317.1 |
| RefSeq Size | 1312 bp |
| RefSeq ORF | 534 bp |
| Locus ID | 5744 |
| UniProt ID | P12272 |
| Cytogenetics | 12p11.22 |
| Protein Families | Druggable Genome, Secreted Protein |
| Summary | The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. provided by RefSeq, Nov 2013 Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Both variants 1 and 4 encode the same isoform (1). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_198966" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC212744 | PTHLH (Myc-DDK-tagged)-Human parathyroid hormone-like hormone (PTHLH), transcript variant 4 | 10 ug |
$300.00
|
|
| RC212744L1 | Lenti ORF clone of Human parathyroid hormone-like hormone (PTHLH), transcript variant 4, Myc-DDK-tagged | 10 ug |
$600.00
|
|
| RC212744L2 | Lenti ORF clone of Human parathyroid hormone-like hormone (PTHLH), transcript variant 4, mGFP tagged | 10 ug |
$600.00
|
|
| RC212744L3 | Lenti ORF clone of Human parathyroid hormone-like hormone (PTHLH), transcript variant 4, Myc-DDK-tagged | 10 ug |
$600.00
|
|
| RC212744L4 | Lenti ORF clone of Human parathyroid hormone-like hormone (PTHLH), transcript variant 4, mGFP tagged | 10 ug |
$600.00
|
|
| RG212744 | PTHLH (tGFP-tagged) - Human parathyroid hormone-like hormone (PTHLH), transcript variant 4 | 10 ug |
$500.00
|
|
Citations
A misplaced lncRNA causes brachydactyly in humans
Maass, Rump, Schulz et al
J. Clin. Invest. (2012) 122 (11), 3990-4002 DOI: 10.1172/JCI65508
Maass, Rump, Schulz et al
J. Clin. Invest. (2012) 122 (11), 3990-4002 DOI: 10.1172/JCI65508
Cited by 11
AI Summary: OriGene products contributed to this study by providing specific shRNA lentiviral particles (TL313374 for PTHLH, TL313376 for SOX9, and TL314627 for the lncRNA) used to silence target genes and investigate their roles in the regulatory feedback mechanism underlying brachydactyly.
Snippet: BDE is characterized by a shortening of metacarpals and metatarsals (3). The morphogenesis gene PTHLH, encoding parathyroid hormone–like hormone on chromosome 12p11.2, has been linked to BDE with short stature (4, 5). PTHLH is involved in the regulation of cartilage
Showing 1-1 of 1 papers.
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