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DDR2 (NM_001014796) Human Untagged Clone

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SKU
SC301955
DDR2 (untagged)-Human discoidin domain receptor tyrosine kinase 2 (DDR2), transcript variant 1
  $784.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol DDR2
Synonyms MIG20a; NTRKR3; TKT; TYRO10; WRCN
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>SC301955 representing NM_001014796.
Blue=Insert sequence Red=Cloning site Green=Tag(s)

GCGGCCGCGAATTCGGCACGAGGTTTCACAACAAATTCTTCTTTTTGGGTTGGGGAAACGCAGTGGATT
ATAGCTCTGTTTTCTTCTTTCCAAAACTGTGCACCCCTGGATGAAACCTCCATCAAGGGAGACCTACAA
GTTGCCTGGGGTTCAGTGCTCTAGAAAGTTCCAAGGTTTGTGGCTTGAATTATTCTAAAGAAGCTGAAA
TAATTGAAGAGAAGCAGAGGCCAGCTGTTTTTGAGGATCCTGCTCCACAGAGAATGCTCTGCACCCGTT
GATACTCCAGTTCCAACACCATCTTCTGAGATGATCCTGATTCCCAGAATGCTCTTGGTGCTGTTCCTG
CTGCTGCCTATCTTGAGTTCTGCAAAAGCTCAGGTTAATCCAGCTATATGCCGCTATCCTCTGGGCATG
TCAGGAGGCCAGATTCCAGATGAGGACATCACAGCTTCCAGTCAGTGGTCAGAGTCCACAGCTGCCAAA
TATGGAAGGCTGGACTCAGAAGAAGGGGATGGAGCCTGGTGCCCTGAGATTCCAGTGGAACCTGATGAC
CTGAAGGAGTTTCTGCAGATTGACTTGCACACCCTCCATTTTATCACTCTGGTGGGGACCCAGGGGCGC
CATGCAGGAGGTCATGGCATCGAGTTTGCCCCCATGTACAAGATCAATTACAGTCGGGATGGCACTCGC
TGGATCTCTTGGCGGAACCGTCATGGGAAACAGGTGCTGGATGGAAATAGTAACCCCTATGACATTTTC
CTAAAGGACTTGGAGCCGCCCATTGTAGCCAGATTTGTCCGGTTCATTCCAGTCACCGACCACTCCATG
AATGTGTGTATGAGAGTGGAGCTTTACGGCTGTGTCTGGCTAGATGGCTTGGTGTCTTACAATGCTCCA
GCTGGGCAGCAGTTTGTACTCCCTGGAGGTTCCATCATTTATCTGAATGATTCTGTCTATGATGGAGCT
GTTGGATACAGCATGACAGAAGGGCTAGGCCAATTGACCGATGGTGTGTCTGGCCTGGACGATTTCACC
CAGACCCATGAATACCACGTGTGGCCCGGCTATGACTATGTGGGCTGGCGGAACGAGAGTGCCACCAAT
GGCTACATTGAGATCATGTTTGAATTTGACCGCATCAGGAATTTCACTACCATGAAGGTCCACTGCAAC
AACATGTTTGCTAAAGGTGTGAAGATCTTTAAGGAGGTACAGTGCTACTTCCGCTCTGAAGCCAGTGAG
TGGGAACCTAATGCCATTTCCTTCCCCCTTGTCCTGGATGACGTCAACCCCAGTGCTCGGTTTGTCACG
GTGCCTCTCCACCACCGAATGGCCAGTGCCATCAAGTGTCAATACCATTTTGCAGATACCTGGATGATG
TTCAGTGAGATCACCTTCCAATCAGATGCTGCAATGTACAACAACTCTGAAGCCCTGCCCACCTCTCCT
ATGGCACCCACAACCTATGATCCAATGCTTAAAGTTGATGACAGCAACACTCGGATCCTGATTGGCTGC
TTGGTGGCCATCATCTTTATCCTCCTGGCCATCATTGTCATCATCCTGTGGAGGCAGTTCTGGCAGAAA
ATGCTGGAGAAGGCTTCTCGGAGGATGCTGGATGATGAAATGACAGTCAGCCTTTCCCTGCCAAGTGAT
TCTAGCATGTTCAACAATAACCGCTCCTCATCACCTAGTGAACAAGGGTCCAACTCGACTTACGATCGC
ATCTTTCCCCTTCGCCCTGACTACCAGGAGCCATCCAGGCTGATACGAAAACTCCCAGAATTTGCTCCA
GGGGAGGAGGAGTCAGGCTGCAGCGGTGTTGTGAAGCCAGTCCAGCCCAGTGGCCCTGAGGGGGTGCCC
CACTATGCAGAGGCTGACATAGTGAACCTCCAAGGAGTGACAGGAGGCAACACATACTCAGTGCCTGCC
GTCACCATGGACCTGCTCTCAGGAAAAGATGTGGCTGTGGAGGAGTTCCCCAGGAAACTCCTAACTTTC
AAAGAGAAGCTGGGAGAAGGACAGTTTGGGGAGGTTCATCTCTGTGAAGTGGAGGGAATGGAAAAATTC
AAAGACAAAGATTTTGCCCTAGATGTCAGTGCCAACCAGCCTGTCCTGGTGGCTGTGAAAATGCTCCGA
GCAGATGCCAACAAGAATGCCAGGAATGATTTTCTTAAGGAGATAAAGATCATGTCTCGGCTCAAGGAC
CCAAACATCATCCATCTATTAGCTGTGTGTATCACTGATGACCCTCTCTGTATGATCACTGAATACATG
GAGAATGGAGATCTCAATCAGTTTCTTTCCCGCCACGAGCCCCCTAATTCTTCCTCCAGCGATGTACGC
ACTGTCAGTTACACCAATCTGAAGTTTATGGCTACCCAAATTGCCTCTGGCATGAAGTACCTTTCCTCT
CTTAATTTTGTTCACCGAGATCTGGCCACACGAAACTGTTTAGTGGGTAAGAACTACACAATCAAGATA
GCTGACTTTGGAATGAGCAGGAACCTGTACAGTGGTGACTATTACCGGATCCAGGGCCGGGCAGTGCTC
CCTATCCGCTGGATGTCTTGGGAGAGTATCTTGCTGGGCAAGTTCACTACAGCAAGTGATGTGTGGGCC
TTTGGGGTTACTTTGTGGGAGACTTTCACCTTTTGTCAAGAACAGCCCTATTCCCAGCTGTCAGATGAA
CAGGTTATTGAGAATACTGGAGAGTTCTTCCGAGACCAAGGGAGGCAGACTTACCTCCCTCAACCAGCC
ATTTGTCCTGACTCTGTGTATAAGCTGATGCTCAGCTGCTGGAGAAGAGATACGAAGAACCGTCCCTCA
TTCCAAGAAATCCACCTTCTGCTCCTTCAACAAGGCGACGAGTGATGCTGTCAGTGCCTGGCCATGTTC
CTACGGCTCAGGTCCTCCCTACAAGACCTACCACTCACCCATGCCTATGCCACTCCATCTGGACATTTA
ATGAAACTGAGAGACAGAGGCTTGTTTGCTTTGCCCTCTTTTCCTGGTCACCCCCACTCCCTACCCCTG
ACTCATATATACTTTTTTTTTTTTTTACATTAAAGAACTAAAAAAAAAAAAAAAAAACTCGACTCTAGA
TTGCGGCCGC
Restriction Sites NotI-NotI |
ACCN NM_001014796
Insert Size 3115 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The ORF of this clone has been fully sequenced and found to be a perfect match to NM_001014796.1.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001014796.1
RefSeq Size 3252 bp
RefSeq ORF 3115 bp
Locus ID 4921
UniProt ID Q16832
Cytogenetics 1q23.3
Protein Families Druggable Genome, Protein Kinase, Transmembrane
MW 117.4 kDa
Summary This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. provided by RefSeq, Aug 2017
Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
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Documents
Resources
"NM_001014796" in other vectors (5)
SKU Description Size Price
RC208745 DDR2 (Myc-DDK-tagged)-Human discoidin domain receptor tyrosine kinase 2 (DDR2), transcript variant 1 10 ug
$783.00
RC208745L3 Lenti ORF clone of Human discoidin domain receptor tyrosine kinase 2 (DDR2), transcript variant 1, Myc-DDK-tagged 10 ug
$1,083.00
RC208745L4 Lenti ORF clone of Human discoidin domain receptor tyrosine kinase 2 (DDR2), transcript variant 1, mGFP tagged 10 ug
$1,083.00
RC600062 DDR2 (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens discoidin domain receptor tyrosine kinase 2, transcript variant 1, Signal peptide (1-21) plus EC domain (22-399) 10 ug
$289.00 $457.00
RG208745 DDR2 (tGFP-tagged) - Human discoidin domain receptor tyrosine kinase 2 (DDR2), transcript variant 1 10 ug
$789.00 $983.00

file-alt Citations

DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1
Xie, Lin, Ye et al
J. Exp. Clin. Cancer Res. (2015) 34 (1), 101 DOI: 10.1186/s13046-015-0218-6
Cited by 101
AI Summary: OriGene products contributed to this study by providing the DDR2 expressing plasmid (pCMV6-XL6), DDR2 shRNA, and scrambled shRNA vector (pRS), which were used to manipulate DDR2 expression and investigate its role in hepatocellular carcinoma cell invasion and signaling pathways.
Snippet: Expressing plasmids and RNAi transfection. The DDR2 expressing plasmid and its empty plasmid pCMV6-XL6 were both obtained from Origene Technologies Inc. ... The DDR2 shRNA and scrambled shRNA vector pRS were also purchased from Origene Technologies ... Cite SaveSaving
FigureFigureFigure
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
Hammerman, Sos, Ramos et al
Cancer Discov (2011) 1 (1), 78-89 DOI: 10.1158/2159-8274.CD-11-0005
Cited by 123
AI Summary: OriGene shRNA-expressing plasmids were used to knock down DDR2 mRNA expression in lung cancer cell lines, enabling the study to demonstrate that DDR2 inhibition selectively kills DDR2-mutant squamous cell lung cancer cells.
Snippet: We screened a set of shRNA-expressing plasmids for the ability to knock down DDR2 mRNA expression by real-time PCR in NCI-H2286 cells and selected 2 hairpins for further analysis because of their ability to reduce DDR2 mRNA levels by approximately 50% (data not
Showing 1-2 of 2 papers.
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