IGFBP3 (NM_001013398) Human Untagged Clone
SKU
SC301776
IGFBP3 (untagged)-Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 1
$300.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | IGFBP3 |
| Synonyms | BP-53; IBP3 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_001013398 |
| Insert Size | 2600 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | There is 1 nucleotide difference between the OriGene clone and the NCBI reference ORF. These result in the substitution of 1 aa and insertion of 1 aa. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_001013398.1, NP_001013416.1 |
| RefSeq Size | 2638 bp |
| RefSeq ORF | 894 bp |
| Locus ID | 3486 |
| UniProt ID | P17936 |
| Cytogenetics | 7p12.3 |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | p53 signaling pathway |
| Summary | This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. provided by RefSeq, Jul 2008 Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_001013398" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC216898 | IGFBP3 (Myc-DDK-tagged)-Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 1 | 10 ug |
$300.00
|
|
| RC216898L1 | Lenti ORF clone of Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 1, Myc-DDK-tagged | 10 ug |
$600.00
|
|
| RC216898L2 | Lenti ORF clone of Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 1, mGFP tagged | 10 ug |
$600.00
|
|
| RC216898L3 | Lenti ORF clone of Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 1, Myc-DDK-tagged | 10 ug |
$600.00
|
|
| RC216898L4 | Lenti ORF clone of Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 1, mGFP tagged | 10 ug |
$600.00
|
|
| RG216898 | IGFBP3 (tGFP-tagged) - Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 1 | 10 ug |
$489.00
$500.00
|
|
Citations
Functional modulation of IGF-binding protein-3 expression in melanoma
Dar, Majid, Nosrati et al
J Invest Dermatol (2010) 130 (8), 2071-9 DOI: 10.1038/jid.2010.70
Dar, Majid, Nosrati et al
J Invest Dermatol (2010) 130 (8), 2071-9 DOI: 10.1038/jid.2010.70
Cited by 31
AI Summary: OriGene products contributed to this study by providing the human IGFBP3 cDNA (OriGene, SC119328) used for overexpression experiments, which enabled the authors to assess the effects of IGFBP3 on melanoma cell survival, apoptosis, and tumor growth.
Showing 1-1 of 1 papers.
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