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Dishevelled 2 (DVL2) (NM_004422) Human Untagged Clone

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SKU
SC128046
DVL2 (untagged)-Human dishevelled, dsh homolog 2 (Drosophila) (DVL2)
  $675.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol Dishevelled 2
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC128046 sequence for NM_004422 edited (data generated by NextGen Sequencing)
ATGGCGGGTAGCAGCACTGGGGGCGGTGGGGTTGGGGAGACGAAGGTGATTTACCACCTG
GATGAGGAAGAGACTCCCTACCTGGTGAAGATCCCTGTCCCCGCCGAGCGCATCACCCTC
GGCGATTTCAAGAGCGTCCTGCAGCGGCCCGCGGGCGCCAAGTACTTTTTCAAGTCTATG
GATCAGGATTTCGGGGTGGTGAAGGAAGAAATTTCAGATGACAACGCCCGCCTCCCCTGC
TTCAACGGAAGGGTGGTATCCTGGCTGGTGTCCTCAGATAATCCCCAACCCGAGATGGCC
CCTCCAGTCCATGAGCCTCGGGCAGAACTGGCGCCTCCAGCCCCACCTTTACCTCCTTTG
CCACCCGAGAGGACCAGCGGCATTGGGGACTCAAGGCCTCCATCCTTCCACCCTAATGTG
TCCAGCAGCCATGAGAATCTGGAGCCTGAGACAGAAACCGAGTCAGTAGTGTCACTGAGG
CGGGAGCGGCCTCGCAGGAGAGACAGCAGTGAGCATGGCGCTGGGGGCCACAGGACTGGT
GGCCCCTCAAGGCTGGAGCGCCACCTGGCCGGATACGAGAGCTCCTCTACCCTCATGACC
AGCGAGCTGGAGAGTACCAGCCTGGGGGACTCGGACGAGGAGGACACCATGAGCAGGTTC
AGCAGCTCCACGGAGCAGAGCAGTGCCTCCCGCCTCCTTAAGCGCCACCGGCGGCGAAGG
AAGCAGAGGCCACCCCGCCTGGAGAGGACGTCATCCTTCAGCAGCGTCACAGATTCCACA
ATGTCTCTCAATATCATCACAGTCACGCTAAACATGGAGAAGTACAACTTCCTGGGTATC
TCCATTGTTGGCCAGAGCAATGAGCGGGGAGACGGAGGCATCTACATTGGCTCCATCATG
AAGGGTGGGGCTGTGGCGGCCGACGGGCGCATTGAGCCAGGGGACATGCTTTTGCAGGTG
AATGACATGAACTTTGAGAACATGAGCAACGATGACGCTGTGCGGGTGCTGAGGGACATT
GTGCACAAGCCTGGCCCCATTGTGCTGACTGTGGCCAAGTGCTGGGATCCCTCTCCTCAG
GCCTATTTCACTCTCCCCCGAAATGAGCCCATCCAGCCAATTGACCCTGCTGCCTGGGTG
TCCCATTCCGCGGCTCTGACTGGCACCTTCCCAGCCTATCCAGGTTCCTCCTCCATGAGC
ACCATTACATCTGGATCGTCTTTGCCTGATGGCTGTGAAGGCCGGGGTCTCTCCGTCCAT
ACGGACATGGCATCGGTGACCAAGGCCATGGCAGCTCCAGAGTCTGGACTGGAAGTCCGG
GACCGCATGTGGCTCAAGATCACCATCCCTAATGCCTTTCTGGGCTCGGATGTGGTTGAC
TGGCTCTACCATCACGTGGAGGGCTTTCCTGAGCGGCGGGAGGCCCGCAAGTATGCCAGC
GGGCTGCTCAAAGCAGGCCTGATCCGACACACCGTCAACAAGATCACCTTCTCTGAGCAG
TGCTATTACGTCTTCGGAGACCTCAGTGGTGGCTGTGAGAGCTACCTAGTCAACCTGTCT
CTCAATGACAACGATGGCTCCAGTGGGGCTTCAGACCAGGATACCCTGGCTCCTCTGCCT
GGGGCCACCCCCTGGCCCCTGCTGCCCACTTTCTCCTACCAATACCCTGCCCCACACCCC
TACAGCCCGCAGCCTCCACCCTACCATGAGCTTTCATCTTACACCTATGGTGGGGGCAGT
GCCAGCAGCCAGCATAGTGAGGGCAGCCGGAGCAGTGGGTCGACACGGAGTGATGGGGGG
GCAGGGCGCACGGGGAGGCCCGAGGAGCGGGCCCCCGAGTCCAAGTCCGGCAGTGGCAGT
GAGTCTGAGCCCTCCAGCCGAGGGGGCAGCCTTCGGCGGGGTGGGGAAGCAAGTGGGACT
AGCGATGGGGGCCCTCCTCCATCCAGAGGCTCAACTGGGGGTGCCCCTAATCTCCGAGCC
CACCCAGGGCTCCATCCCTATGGACCGCCCCCTGGCATGGCCCTCCCCTACAACCCCATG
ATGGTGGTCATGATGCCCCCACCTCCACCTCCAGTCCCTCCAGCAGTGCAGCCTCCGGGG
GCCCCTCCAGTCAGAGACCTGGGCTCTGTGCCCCCAGAACTGACAGCCAGCCGCCAAAGC
TTCCACATGGCCATGGGCAATCCCAGCGAGTTCTTTGTGGATGTTATGTAG

Clone variation with respect to NM_004422.2
5' Read Nucleotide Sequence
>OriGene 5' read for NM_004422 unedited
GCCACAGGAGCTACACGAATACCACAGGGCGGCCGCGAAACGGCACGAGGGGGCGGCGGA
GCCCGGGAGCGCGCGGGCGAGACACGGCGGGAAGCAGCACCGGGGGCGGCGGGGACGGGG
AGACGAAGGCGATCTACCACCTGGATGAGGAAGAGACTCCCTACCTGGTGAAGACCCCTG
TCCCCGCCGAGCGCATCACCCTCGGCGATTTCAAGAGCGTCCTGCAGCGGCCCGCGGGCG
CCAAGTACTTTTTCAAGTCTATGGATCAGGATTTCGGGGTGGTGAAGGAAGAAATTTCAG
ATGACAACGCCCGCCTCCCCTGCTTCAACGGAAGGGTGGTATCCTGGCTGGTGTCCTCAG
ATAATCCCCAACCCGAGATGGCCCCTCCAGTCCATGAGCCTCGGGCAGAACTGGCGCCTC
CAGCCCCACCTTTACCTCCTTTGCCACCCGAGAGGACCAGCGGCATTGGGGACTCAAGGC
CTCCATCCTTCCACCCTAATGTGTCCAGCAGCCATGAGAATCTGGAGCCTGAGACAGAAA
CCGAGTCAGTAGTGTCACTGAGGCGGGAGCGGCCTCGCAGGAGAGACAGCAGTGAGCATG
GCGCTGGGGGCCACAGGACTGGTGGCCCCTCAAGGCTGGAGCGCCACCTGGCCGGATACG
AGAGCTCCTCTACCCTCATGACCAGCGAGCTGGAGAGTACCAGCCTGGGGGACTCGGACG
AGAGGACACCATGAGCAGTTCAGCAGCTCCACGGAGCAGAGCAGTGCCTCCCGCCTCCTT
AAGCGCCACCGGCGGCGAAGAAGCAGAGGCCACCCCCGCCTGAGAGGACGTCATCCTTCA
GCAGCGTCACAGATTCCACAATGTCTCTCATATCATCACAGTCACGCTAAACATGGAGAA
GTACACTTCCTGGGTATCTCCATTGTTGGCCAGAGCAATGAGCGGGGGAGACGAAGCATC
TACA
3' Read Nucleotide Sequence
>Forward primer walk for NM_004422 unedited
GGGGCCCCTTCCATCCATCCTCCTCATGCAGCCTCCGGGGCCCCTCCATCAGAGACCTGG
GCTCTGTGCCCCCANAACTGACAGCCAGCCGCCAAAGCTTCCACATGGCCATGGGCAATC
CCAGCGAGTTCTTTGTGGATGTTATGTAGCCCACTGTGGGGCCAGGCTGGGCCGGGCGCT
CCTGGTGTGTGACTGGGTGTCCTGGCCGTCATGTGCTTGCTCTTACAGTGCCTGGGCTCA
GCCTACCAGCTGCTGCCATACAGGAGATTGTGGCCACTGTGACTCTCACCAGCAGTGCCT
GGTTCCTCCCCCTTCCCTCAGGGGTAGACAAGGGACCTTTGATTATTTTTAGCTTTGTTT
TTTTATAAGCCTTTTTGGGGGTTAAAATAGAGTTTCTTACATTTTTGGGACTTTTTTAAT
AGGCATTTCCTCTTTTATATGAAGAATTCCCATCCATTGGGCCCCTTCTAACCCCAGAAT
GTGACCTCCTCCTCCAGTTACCCACAGCCCTGCCCTTTGCAGGGTTGGGGGTGGTCAGCG
GTACCCCGGGGTTAGGCATCCTAGACAGCAGCCTGAGGAAGCTGGGAGATTTGGGCCATG
TAGCTGCCTTTGTTACTCTATTTATTTTAGTCACTTGTATAAAACACCAAATAAAGCAAT
AGAGGCAAACTCAAAANANAAAAANGACAAGAAGGAAGGTGCGGAGGGCAAACCTGCGCC
ACACACAAAAAATCCAACACAAGAAAGACCCAAAGAAAANAAGAAGCGAGACAACCCCAC
CTAAATAAAGAAAACTTCTTTTTTGTTTGGGGGCCGGGACAATTATTTTTTCCAAAAAAA
ATCCGG
Restriction Sites NotI-NotI |
ACCN NM_004422
Insert Size 3050 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_004422.2, NP_004413.1
RefSeq Size 3046 bp
RefSeq ORF 2211 bp
Locus ID 1856
UniProt ID O14641
Cytogenetics 17p13.1
Domains DAX, DEP, Dishevelled, PDZ
Protein Families Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways Basal cell carcinoma, Colorectal cancer, Melanogenesis, Notch signaling pathway, Pathways in cancer, Wnt signaling pathway
Summary This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. provided by RefSeq, Jul 2008
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Documents
Resources
"NM_004422" in other vectors (6)
SKU Description Size Price
RC202233 DVL2 (Myc-DDK-tagged)-Human dishevelled, dsh homolog 2 (Drosophila) (DVL2) 10 ug
$674.00
RC202233L1 Lenti ORF clone of Human dishevelled, dsh homolog 2 (Drosophila) (DVL2), Myc-DDK-tagged 10 ug
$974.00
RC202233L2 Lenti ORF clone of Human dishevelled, dsh homolog 2 (Drosophila) (DVL2), mGFP tagged 10 ug
$974.00
RC202233L3 Lenti ORF clone of Human dishevelled, dsh homolog 2 (Drosophila) (DVL2), Myc-DDK-tagged 10 ug
$974.00
RC202233L4 Lenti ORF clone of Human dishevelled, dsh homolog 2 (Drosophila) (DVL2), mGFP tagged 10 ug
$974.00
RG202233 DVL2 (tGFP-tagged) - Human dishevelled, dsh homolog 2 (Drosophila) (DVL2) 10 ug
$789.00 $874.00

file-alt Citations

The Wnt pathway protein Dvl1 targets Somatostatin receptor 2 for lysosome-dependent degradation
Carr, Zuo, Frost
J Biol Chem (2023) 299 (5), 104645 DOI: 10.1016/j.jbc.2023.104645
Cited by 4
AI Summary: In this study, OriGene products including the SSTR2 Myc-DDK tagged expression plasmid (OriGene #RC211447) and DVL1 Myc-DDK tagged expression plasmid (OriGene #RC200768) were used to overexpress Sstr2 and Dvl1 in cell lines, enabling the investigation of their interactions and the role of Dvl1 in targeting Sstr2 for lysosome-dependent degradation.
Snippet: signals to other proteins such as GIRKs and SHP-1 (52, 53), it would be interesting to know the full spectrum of Sstr2-dependent signaling pathways modulated by Dvl1. Wnts are well known to drive tumorigenesis and there is some evidence for elevated Wnt pathway signaling in neuroendocrine tumors. For example, expression of the Wnt decoy receptors sFRP2, sFRP4, and Wif1 are downregulated in pituit
Showing 1-1 of 1 papers.
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