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AF9 (MLLT3) (NM_004529) Human Untagged Clone

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SKU
SC127943
MLLT3 (untagged)-Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), translocated to, 3 (MLLT3)
  $530.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol AF9
Synonyms AF9; YEATS3
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC127943 sequence for NM_004529 edited (data generated by NextGen Sequencing)
ATGGCTAGCTCGTGTGCCGTGCAGGTGAAGCTGGAGCTGGGGCACCGCGCCCAGGTGAGG
AAAAAACCCACCGTGGAGGGCTTCACCCACGACTGGATGGTGTTCGTACGCGGTCCGGAG
CACAGTAACATACAGCACTTTGTGGAGAAAGTCGTCTTCCACTTGCACGAAAGCTTTCCT
AGGCCAAAAAGAGTGTGCAAAGATCCACCTTACAAAGTAGAAGAATCTGGGTATGCTGGT
TTCATTTTGCCAATTGAAGTTTATTTTAAAAACAAGGAAGAACCTAGGAAAGTCCGCTTT
GATTATGACTTATTCCTGCATCTTGAAGGCCATCCACCAGTGAATCACCTCCGCTGTGAA
AAGCTAACTTTCAACAACCCCACAGAGGACTTTAGGAGAAAGTTGCTGAAGGCAGGAGGG
GACCCTAATAGGAGTATTCATACCAGCAGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGC
AGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGTAGCAGC
AGCAGTAGCAGCAGCAGCAGCAGCAGTAGTACCAGTTTTTCAAAGCCTCACAAATTAATG
AAGGAGCACAAGGAAAAACCTTCTAAAGACTCCAGAGAACATAAAAGTGCCTTCAAAGAA
CCTTCCAGGGATCACAACAAATCTTCCAAAGAATCCTCTAAGAAACCCAAAGAAAATAAA
CCACTGAAAGAAGAGAAAATAGTTCCTAAGATGGCCTTCAAGGAACCTAAACCCATGTCA
AAAGAGCCAAAACCAGATAGTAACTTACTCACCATCACCAGTGGACAAGATAAGAAGGCT
CCTAGTAAAAGGCCGCCCATTTCAGATTCTGAAGAACTCTCAGCCAAAAAAAGGAAAAAG
AGTAGCTCAGAGGCTTTATTTAAAAGTTTTTCTAGCGCACCACCACTGATACTCACTTGT
TCTGCTGACAAAAAACAGATAAAAGATAAATCTCATGTCAAGATGGGAAAGGTCAAAATT
GAAAGTGAGACATCAGAGAAGAAGAAATCAACGTTACCGCCATTTGATGATATTGTGGAT
CCCAATGATTCAGATGTGGAGGAGAATATATCCTCTAAATCTGATTCTGAACAACCCAGT
CCTGCCAGCTCCAGCTCCAGCTCCAGCTCCAGCTTCACACCATCCCAGACCAGGCAACAA
GGTCCTTTGAGGTCTATAATGAAAGATCTGCATTCTGATGACAATGAGGAGGAATCAGAT
GAAGTGGAGGATAACGACAATGACTCTGAAATGGAGAGGCCTGTAAATAGAGGAGGCAGC
CGAAGTCGCAGAGTTAGCTTAAGTGATGGCAGCGATAGTGAAAGCAGTTCTGCTTCTTCA
CCCCTACATCACGAACCTCCACCACCCTTACTAAAAACCAACAACAACCAGATTCTTGAA
GTGAAAAGTCCAATAAAGCAAAGCAAATCAGATAAGCAAATAAAGAATGGTGAATGTGAC
AAGGCATACCTAGATGAACTGGTAGAGCTTCACAGAAGGTTAATGACATTGAGAGAAAGA
CACATTCTGCAGCAGATCGTGAACCTTATAGAAGAAACTGGACACTTTCATATCACAAAC
ACAACATTTGATTTTGATCTTTGCTCGCTGGACAAAACCACAGTCCGTAAACTACAGAGT
TACCTGGAAACATCTGGAACATCCTGA

Clone variation with respect to NM_004529.2
5' Read Nucleotide Sequence
>OriGene 5' read for NM_004529 unedited
TTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGCATGCTCCGCAAT
CATCTTCTTTACCCTGGAGCTGCTGCTGCTGCTGCTGCTTTTGCTTTTGGGGCTGAGTTT
AATAAGCGAGCGAGCGAGCAAGCGAGCGCGGGGGGAAAAAGGCAGAGAATGTCCGCCATC
TACCCTCCGCTCCTGGGCGCGCTCTCATTCATAGCAGCCTCTTCATGAATTACAGCTGAG
GGGGGGCGGAGGAGGGGGGGGTACCACACAACACCCCAGCAAACCTCCGGGCCCCCAGGC
ATGGCTAGCTCGTGTGCCGTGCAGGTGAAGCTGGAGCTGGGGCACCGCGCCCAGGTGAGG
AAAAAACCCACCGTGGAGGGCTTCACCCACGACTGGATGGTGTTCGTACGCGGTCCGGAG
CACAGTAACATACAGCACTTTGTGGAGAAAGTCGTCTTCCACTTGCACGAAGCTTCCTAG
CCAAAGAGGGCAAGATCACCTTACAAGAAAAATTGGGATGCGGTATTTGCATGAATTATT
TAAAACAGAAAACCTAGAACCGTTGAATGACTTATCGCTCTGAGCCTCACCGGAATACCT
CGTGGAAAGTACTTCACACCCACGAGACTTAGGAGAAGTGCTGAGGCANGAGGGGGACCC
TATAAGAGTATNCATACCAGCAGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGCAGCAGC
AGCAGCAGCAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGTAGCAGCAGCAGT
AGCAGCAGCAGCAGCAGCAGTAGTACCAGTTTTTTCAAGGCCTACAATNAATGAAAGGAG
CCA
3' Read Nucleotide Sequence
>OriGene 3' read for NM_004529 unedited
TTCAAAACAGGGTACAACAAGAAACAAAAAAATCCCCCCATCCCCAACCGTCTTTCACCA
ATACAAGAAATCCTTCTGGAAATATTAGCAAGCAACTAAACAGGTATTGAACCACTGAAT
CTACAAGTTAATACATAATCTGTTATGGCAGAATAACCAAGAATTTTTCCCCAAAGAAAG
ATTTTAATTTTTTCAAATATAAAAGTGTCTAAGAGAATCATATGTGAACA
Restriction Sites NotI-NotI |
ACCN NM_004529
Insert Size 3200 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_004529.1, NP_004520.1
RefSeq Size 3376 bp
RefSeq ORF 1707 bp
Locus ID 4300
UniProt ID P42568
Cytogenetics 9p21.3
Domains YEATS
Protein Families Transcription Factors
Summary Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619).UniProtKB/Swiss-Prot Function
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
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"NM_004529" in other vectors (6)
SKU Description Size Price
RC206283 MLLT3 (Myc-DDK-tagged)-Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), translocated to, 3 (MLLT3) 10 ug
$529.00
RC206283L1 Lenti ORF clone of Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3), Myc-DDK-tagged 10 ug
$829.00
RC206283L2 Lenti ORF clone of Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3), mGFP tagged 10 ug
$829.00
RC206283L3 Lenti ORF clone of Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3), Myc-DDK-tagged 10 ug
$829.00
RC206283L4 Lenti ORF clone of Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3), mGFP tagged 10 ug
$829.00
RG206283 MLLT3 (tGFP-tagged) - Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3) 10 ug
$489.00 $729.00

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