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SREBP2 (SREBF2) (NM_004599) Human Untagged Clone

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SKU
SC127910
SREBF2 (untagged)-Human sterol regulatory element binding transcription factor 2 (SREBF2)
  $1,491.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol SREBP2
Synonyms bHLHd2; SREBP-2; SREBP2
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC127910 sequence for NM_004599 edited (data generated by NextGen Sequencing)
ATGGACGACAGCGGCGAGCTGGGTGGTCTGGAGACCATGGAGACCCTCACGGAGCTGGGC
GACGAGCTGACCCTGGGAGACATCGACGAGATGCTGCAATTTGTCAGTAATCAAGTGGGA
GAGTTCCCTGACTTGTTTTCAGAACAGCTGTGTAGCTCCTTTCCTGGCAGTGGTGGTAGT
GGTAGCAGCAGCGGCAGCAGTGGCAGCAGCAGCAGCAGCAGCAATGGCAGGGGCAGCAGC
AGCGGAGCTGTGGACCCTTCAGTGCAACGGTCATTCACCCAGGTCACATTACCTTCCTTC
TCTCCCTCGGCGGCCTCCCCACAGGCTCCAACTCTGCAAGTCAAGGTTTCTCCCACCTCA
GTTCCCACCACACCCAGGGCAACTCCTATTCTTCAGCCCCGCCCCCAGCCCCAGCCTCAA
CCTCAAACTCAGCTGCAACAACAGACGGTAATGATCACGCCAACATTCAGCACCACTCCG
CAGACGAGGATCATCCAGCAGCCTTTGATATACCAGAATGCAGCTACTAGCTTTCAAGTC
CTTCAGCCTCAAGTCCAAAGCCTGGTGACATCCTCCCAGGTACAGCCGGTCACCATTCAG
CAGCAGGTGCAGACAGTACAGGCCCAGCGGGTGCTGACACAAACGGCCAATGGCACGCTG
CAGACCCTTGCCCCGGCTACGGTGCAGACAGTTGCTGCGCCACAGGTGCAGCAGGTCCCG
GTCCTGGTCCAGCCTCAGATCATCAAGACAGATTCCCTTGTTTTGACCACACTGAAGACA
GATGGCAGCCCTGTTATGGCTGCGGTCCAGAACCCGGCCCTCACCGCCCTCACCACCCCT
ATCCAGACGGCTGCCCTTCAAGTACCAACCCTGGTGGGCAGCAGTGGGACCATTCTGACC
ACAATGCCTGTAATGATGGGGCAAGAGAAAGTGCCCATTAAGCAGGTACCTGGGGGAGTC
AAGCAGCTTGAGCCCCCCAAAGAAGGAGAAAGGCGGACAACCCATAATATCATTGAGAAA
CGATATCGCTCCTCCATCAATGACAAAATCATCGAATTGAAAGACCTGGTCATGGGGACA
GACGCCAAGATGCACAAGTCTGGCGTTCTGAGGAAGGCCATTGATTACATCAAATACTTG
CAGCAGGTCAATCATAAACTGCGCCAGGAGAACATGGTGCTGAAGCTGGCAAATCAAAAG
AACAAGCTTCTAAAGGGCATCGACCTAGGCAGTCTGGTGGACAATGAGGTGGACCTGAAG
ATCGAGGACTTTAATCAGAATGTCCTTCTGATGTCCCCCCCAGCCTCTGACTCAGGGTCC
CAGGCTGGCTTCTCTCCCTACTCCATTGACTCTGAGCCAGGAAGCCCTCTATTGGATGAT
GCAAAGGTCAAAGATGAGCCAGACTCTCCTCCTGTGGCGCTGGGCATGGTAGACCGCTCA
CGGATTCTTCTGTGTGTCCTCACCTTCCTGTGCCTCTCCTTTAACCCCCTGACTTCCCTG
CTGCAGTGGGGAGGGGCCCACGACTCTGACCAGCACCCACACTCAGGCTCTGGCCGCAGT
GTCCTGTCATTCGAGTCAGGTTCTGGGGGCTGGTTTGACTGGATGATGCCTACTCTTCTC
TTATGGCTGGTAAATGGTGTGATTGTCCTGAGCGTCTTTGTGAAGCTGCTGGTTCATGGG
GAGCCAGTGATCCGGCCACACTCGCGCTCCTCGGTCACCTTCTGGAGGCACCGGAAACAG
GCAGATCTGGATCTCGCCAGAGGAGATTTTGCAGCTGCTGCCGGCAACCTACAAACCTGC
CTGGCAGTTTTGGGCCGGGCACTGCCCACCTCCCGCCTGGACCTGGCCTGCAGCCTCTCC
TGGAACGTGATCCGCTACAGCCTGCAGAAGCTACGCCTGGTGCGCTGGCTGCTCAAGAAA
GTCTTCCAGTGCCGGCGGGCCACGCCAGCCACTGAGGCAGGCTTTGAAGACGAAGCTAAG
ACCAGCGCCCGGGATGCGGCTCTGGCCTATCACCGGCTGCACCAGCTGCACATCACAGGG
AAGCTTCCTGCAGGATCCGCCTGTTCCGATGTACACATGGCGTTGTGTGCCGTGAACCTG
GCTGAATGTGCAGAGGAGAAGATCCCACCGAGCACACTGGTTGAGATCCATCTGACTGCT
GCCATGGGGCTCAAGACCCGGTGTGGAGGCAAGCTGGGCTTCCTGGCCAGCTACTTCCTC
AGCCGAGCCCAGAGCCTGTGTGGCCCCGAGCACAGTGCTGTTCCTGACTCCCTGCGCTGG
CTCTGCCACCCCCTGGGCCAGAAGTTTTTCATGGAGCGGAGCTGGTCTGTGAAGTCAGCT
GCCAAGGAGAGTCTATACTGTGCCCAGAGGAACCCAGCTGACCCCATTGCGCAGGTCCAC
CAGGCCTTCTGCAAGAACCTGCTGGAGCGAGCTATAGAGTCCTTGGTGAAACCTCAGGCC
AAGAAGAAGGCTGGAGACCAGGAAGAAGAGAGCTGTGAATTCTCCAGTGCTCTGGAGTAC
TTGAAATTACTTCATTCTTTTGTGGACTCTGTGGGGGTTATGAGCCCCCCACTCTCCAGG
AGCTCCGTGCTCAAGTCCGCCCTGGGTCCAGACATCATCTGTCGGTGGTGGACGTCTGCA
ATCACTGTGGCCATCAGCTGGCTCCAGGGAGACGATGCAGCTGTGCGCTCTCATTTTACC
AAAGTGGAACGCATCCCCAAGGCCCTGGAAGTGACAGAGAGCCCCCTGGTGAAGGCCATC
TTCCATGCCTGCAGAGCCATGCATGCCTCACTCCCTGGGAAAGCAGATGGGCAGCAGAGT
TCCTTCTGCCATTGCGAGAGGGCCAGTGGCCACCTATGGAGCAGCCTCAACGTCAGTGGG
GCCACCTCTGACCCTGCCCTCAACCACGTGGTCCAGCTGCTCACCTGTGACCTGCTACTG
TCGCTACGGACAGCGCTCTGGCAAAAACAGGCCAGTGCCAGCCAGGCTGTGGGGGAGACC
TACCACGCGTCAGGCGCTGAACTGGCGGGCTTCCAACGGGACCTGGGCAGCCTGCGCAGG
CTGGCACACAGCTTCCGCCCAGCATACCGCAAGGTGTTCCTGCATGAAGCCACCGTGCGC
CTGATGGCAGGAGCCAGCCCCACCCGCACCCACCAGCTGCTGGAACACAGCCTGCGGCGG
CGCACCACGCAGAGCACCAAGCACGGAGAGGTGGATGCCTGGCCCGGCCAGCGAGAGCGG
GCCACCGCCATCCTGCTGGCCTGCCGCCACCTGCCCCTCTCCTTCCTCTCCTCCCCGGGC
CAGCGGGCAGTGCTGCTGGCCGAAGCTGCCCGCACCCTGGAGAAGGTGGGCGACCGGCGC
TCCTGCAACGACTGCCAGCAGATGATTGTTAAGCTGGGTGGTGGCACTGCCATTGCCGCC
TCCTGA

Clone variation with respect to NM_004599.2
5' Read Nucleotide Sequence
>OriGene 5' read for NM_004599 unedited
TTTGGTATACGACTCAATATAGGGCGGCCGCGATATCGGCACGAGTGCGCAACCATGGCG
GCGGGTGGCAACCCGTCGGTGAGGCGGTGCCGGGCGGGGGTTGTCGGGTGTCATTGGGCG
GTGGCGACGGCACCGCCCCCGCGTCTCCCTTGAGCGGGACGGCAGGGGGGGCTTCTGCGC
TGAGCCGGGCGATGGACGACAGCGGCGAGCTGGGTGGTCTGGAGACCATGGAGACCCTCA
CGGAGCTGGGCGACGAGCTGACCCTGGGAGACATCGACGAGATGCTGCAATNTTGTCAGT
AANTCAAGTGGGAGAGTTCCCTGACTTGTTTTCAGAACAGCTGTGTAGCTCCTTTCCTGG
CAGTGGTGGTTAGTGGTAGCAGCAGCGGCAGCAGTGGCAGCAGCAGCAGCAGCAGCAATG
GCAGGGGCAGCAGCAGCGGGAGCTGTGGACCCTTCATGNCAACGGTCATTCACCCAGGTC
ACATTACCTTCCTTCTCTCCCTCGGCGGCCTCCCCACAGGCTCCAACTCTGCAAGTAAAG
GTTTCTCCCACCTCAGTTCCCACCACACCCAGGGCAACTCCTATTCTTCAGCCCCGCCCC
CAGCCCCAGCCTCAACCTCAAACTCAGCTGCAACAACAGACGGGNNATGATCACGCCAAC
ATTCAGCACCACTCCGCAGACCGAGGATCATCCANCAGCCTTTGATATACCAGATGCAGC
TACTAGCTTTTCAAGTCTTTAGCCTCAGTCCAAAGCCTGGTGGACATCTCCAGTAACAAG
CCGTCACCATAACAACAGGGGCAACAGTCAGCCCCCCGGGGGGGCTAACACAACGGCCAT
GGACGCTTGAAACCTTTGCCGGNTAGGGGGAAAAAATTGCTCCCCAGGGCACAAAAACCC
CGCCTA
Restriction Sites NotI-NotI |
ACCN NM_004599
Insert Size 4700 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_004599.2, NP_004590.2
RefSeq Size 4325 bp
RefSeq ORF 3426 bp
Locus ID 6721
UniProt ID Q12772
Cytogenetics 22q13.2
Domains HLH
Protein Families Druggable Genome, Transcription Factors
Summary This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. provided by RefSeq, Jul 2013
Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
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Documents
Resources
"NM_004599" in other vectors (6)
SKU Description Size Price
RC208942 SREBF2 (Myc-DDK-tagged)-Human sterol regulatory element binding transcription factor 2 (SREBF2) 10 ug
$1,490.00
RC208942L1 Lenti ORF clone of Human sterol regulatory element binding transcription factor 2 (SREBF2), Myc-DDK-tagged 10 ug
$1,790.00
RC208942L2 Lenti ORF clone of Human sterol regulatory element binding transcription factor 2 (SREBF2), mGFP tagged 10 ug
$1,790.00
RC208942L3 Lenti ORF clone of Human sterol regulatory element binding transcription factor 2 (SREBF2), Myc-DDK-tagged 10 ug
$1,790.00
RC208942L4 Lenti ORF clone of Human sterol regulatory element binding transcription factor 2 (SREBF2), mGFP tagged 10 ug
$1,790.00
RG208942 SREBF2 (tGFP-tagged) - Human sterol regulatory element binding transcription factor 2 (SREBF2) 10 ug
$1,690.00

file-alt Citations

FoxO4 Interacts with the Sterol Regulatory Factor SREBP2 and the Hypoxia Inducible Factor HIF2α at the CYP51 Promoter
Zhu, Jiang, Chehab
J. Lipid Res. (2013)
AI Summary: OriGene contributed to this study by providing the full-length human SREBP2 cDNA clone (in plasmid pCMV6-XL4), which was used to investigate the interactions of SREBP2 with FoxO4 and HIF2α at the CYP51 promoter.
Snippet: fragment and subcloned in the luciferase vector pGL3. A full length human SREBP2 cDNA clone was obtained from Origene (Rockville, MD) in the plasmid pCMV6-XL4 and its mature nuclear form (nSREBP2) extending from amino acids 2-468 was amplified by PCR ... Cite SaveSaving
Showing 1-1 of 1 papers.
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