LILRB1 (NM_006669) Human Untagged Clone
SKU
SC127469
LILRB1 (untagged)-Human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (LILRB1), transcript variant 1
$606.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | LILRB1 |
| Synonyms | CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7; MIR7; PIR-B; PIRB |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_006669 |
| Insert Size | 2880 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_006669.2, NP_006660.1 |
| RefSeq Size | 2984 bp |
| RefSeq ORF | 1953 bp |
| Locus ID | 10859 |
| UniProt ID | Q8NHL6 |
| Cytogenetics | 19q13.42 |
| Domains | ig, IG, IGc2 |
| Protein Families | Transmembrane |
| Summary | This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2008 Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Sequence Note: A downstream translational start codon is selected for this RefSeq based on its better conservation in mammalian species and on the presence of a predicted signal peptide in the protein N-terminus. An upstream in-frame start codon is also present but is only conserved in primates, and use of the upstream start codon would result in a protein that is 17 aa longer at the N-terminus and lacks a predicted signal peptide. Leaky scanning by ribosomes may allow translation initiation at the downstream start codon. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_006669" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC219949 | LILRB1 (Myc-DDK-tagged)-Human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (LILRB1), transcript variant 1 | 10 ug |
$605.00
|
|
| RC219949L1 | Lenti ORF clone of Human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (LILRB1), transcript variant 1, Myc-DDK-tagged | 10 ug |
$905.00
|
|
| RC219949L2 | Lenti ORF clone of Human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (LILRB1), transcript variant 1, mGFP tagged | 10 ug |
$905.00
|
|
| RC219949L3 | Lenti ORF clone of Human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (LILRB1), transcript variant 1, Myc-DDK-tagged | 10 ug |
$905.00
|
|
| RC219949L4 | Lenti ORF clone of Human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (LILRB1), transcript variant 1, mGFP tagged | 10 ug |
$905.00
|
|
| RG219949 | LILRB1 (tGFP-tagged) - Human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (LILRB1), transcript variant 1 | 10 ug |
$489.00
$805.00
|
|
Citations
A Mechanistic Investigation of Fc? R Signaling During Antibody-enhanced Dengue Infection
ONG ZIYING
Thesis (2015)
ONG ZIYING
Thesis (2015)
Snippet: Uptake was assessed using DiD or Alexa 488 labelled DENV as previously described (Chan et al, 2011;Zhang et al, 2010). Virus replication was assessed at indicated time-points using qPCR. Cells were washed thrice in PBS, followed by RNA extraction using RNAeasy kit (Qiagen), cDNA synthesis (Biorad) and real-time qPCR (Roche) according to manufacturer’s protocol. DENV primers used were: DEN-F ...
Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue
Chan, Ong, Tan
Proceedings of the National Academy of Sciences of the United States of America (2014)
Chan, Ong, Tan
Proceedings of the National Academy of Sciences of the United States of America (2014)
AI Summary: OriGene's pCMV-XL5 vector was used to clone and express the extracellular portion of LILRB1 in HEK293T cells, facilitating experiments on the receptor's role in antibody-dependent dengue.
Showing 1-2 of 2 papers.
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