TIGIT (NM_173799) Human Untagged Clone
$450.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | TIGIT |
| Synonyms | VSIG9; VSTM3; WUCAM |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_173799 |
| Insert Size | 3100 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_173799.2, NP_776160.1 |
| RefSeq Size | 2139 bp |
| RefSeq ORF | 735 bp |
| Locus ID | 201633 |
| UniProt ID | Q495A1 |
| Cytogenetics | 3q13.31 |
| Protein Families | Transmembrane |
| Summary | This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.provided by RefSeq, Sep 2009 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_173799" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC221447 | TIGIT (Myc-DDK-tagged)-Human T cell immunoreceptor with Ig and ITIM domains (TIGIT) | 10 ug |
$450.00
|
|
| RC221447L1 | Lenti ORF clone of Human T cell immunoreceptor with Ig and ITIM domains (TIGIT), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC221447L2 | Lenti ORF clone of Human T cell immunoreceptor with Ig and ITIM domains (TIGIT), mGFP tagged | 10 ug |
$750.00
|
|
| RC221447L3 | Lenti ORF clone of Human T cell immunoreceptor with Ig and ITIM domains (TIGIT), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC221447L4 | Lenti ORF clone of Human T cell immunoreceptor with Ig and ITIM domains (TIGIT), mGFP tagged | 10 ug |
$750.00
|
|
| RG221447 | TIGIT (tGFP-tagged) - Human T cell immunoreceptor with Ig and ITIM domains (TIGIT) | 10 ug |
$489.00
$650.00
|
|
Citations
Increased expression of TIGIT on CD4(+) T cells ameliorates immune-mediated bone marrow failure of aplastic anemia
Zhang, Wang, Zhou et al
J. Cell. Biochem. (2014)
Zhang, Wang, Zhou et al
J. Cell. Biochem. (2014)
Cited by 29
AI Summary: OriGene’s pCMV6-XL5-TIGIT plasmid (SC124474) was used in this study to overexpress TIGIT in human CD4(+) T cells, enabling the researchers to investigate TIGIT’s role in regulating immune responses in aplastic anemia.
Snippet: Accepted Article Page 8. 8 (SC124474, pCMV6-XL5-TIGIT) was purchased from OriGene Technologies (Rockville, MD). Transfection was performed using the LipofectamineTM RNAiMAX (Invitrogen, Carlsbad, CA) as suggested by the manufacturer. ... Related articles All 2 versions Cite SaveSaving
Showing 1-1 of 1 papers.
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