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ROR alpha (RORA) (NM_134261) Human Untagged Clone

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SKU
SC123126
RORA (untagged)-Human RAR-related orphan receptor A (RORA), transcript variant 1
  $488.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol ROR alpha
Synonyms IDDECA; NR1F1; ROR1; ROR2; ROR3; RZR-ALPHA; RZRA
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_134261 edited
GAAAAAACATGGAGTCAGCTCCGGCAGCCCCCGACCCCGCCGCCAGCGAGCCAGGCAGCA
GCGGCGCGGACGCGGCCGCCGGCTCCAGGGAGACCCCGCTGAACCAGGAATCCGCCCGCA
AGAGCGAGCCGCCTGCCCCGGTGCGCAGACAGAGCTATTCCAGCACCAGCAGAGGTATCT
CAGTAACGAAGAAGACACATACATCTCAAATTGAAATTATTCCATGCAAGATCTGTGGAG
ACAAATCATCAGGAATCCATTATGGTGTCATTACATGTGAAGGCTGCAAGGGCTTTTTCA
GGAGAAGTCAGCAAAGCAATGCCACCTACTCCTGTCCTCGTCAGAAGAACTGTTTGATTG
ATCGAACCAGTAGAAACCGCTGCCAACACTGTCGATTACAGAAATGCCTTGCCGTAGGGA
TGTCTCGAGATGCTGTAAAATTTGGCCGAATGTCAAAAAAGCAGAGAGACAGCTTGTATG
CAGAAGTACAGAAACACCGGATGCAGCAGCAGCAGCGCGACCACCAGCAGCAGCCTGGAG
AGGCTGAGCCGCTGACGCCCACCTACAACATCTCGGCCAACGGGCTGACGGAACTTCACG
ACGACCTCAGTAACTACATTGACGGGCACACCCCTGAGGGGAGTAAGGCAGACTCCGCCG
TCAGCAGCTTCTACCTGGACATACAGCCTTCCCCAGACCAGTCAGGTCTTGATATCAATG
GAATCAAACCAGAACCAATATGTGACTACACACCAGCATCAGGCTTCTTTCCCTACTGTT
CGTTCACCAACGGCGAGACTTCCCCAACTGTGTCCATGGCAGAATTAGAACACCTTGCAC
AGAATATATCTAAATCGCATCTGGAAACCTGCCAATACTTGAGAGAAGAGCTCCAGCAGA
TAACGTGGCAGACCTTTTTACAGGAAGAAATTGAGAACTATCAAAACAAGCAGCGGGAGG
TGATGTGGCAATTGTGTGCCATCAAAATTACAGAAGCTATACAGTATGTGGTGGAGTTTG
CCAAACGCATTGATGGATTTATGGAACTGTGTCAAAATGATCAAATTGTGCTTCTAAAAG
CAGGTTCTCTAGAGGTGGTGTTTATCAGAATGTGCCGTGCCTTTGACTCTCAGAACAACA
CCGTGTACTTTGATGGGAAGTATGCCAGCCCCGACGTCTTCAAATCCTTAGGTTGTGAAG
ACTTTATTAGCTTTGTGTTTGAATTTGGAAAGAGTTTATGTTCTATGCACCTGACTGAAG
ATGAAATTGCATTATTTTCTGCATTTGTACTGATGTCAGCAGATCGCTCATGGCTGCAAG
AAAAGGTAAAAATTGAAAAACTGCAACAGAAAATTCAGCTAGCTCTTCAACACGTCCTAC
AGAAGAATCACCGAGAAGATGGAATACTAACAAAGTTAATATGCAAGGTGTCTACATTAA
GAGCCTTATGTGGACGACATACAGAAAAGCTAATGGCATTTAAAGCAATATACCCAGACA
TTGTGCGACTTCATTTTCCTCCATTATACAAGGAGTTGTTCACTTCAGAATTTGAGCCAG
CAATGCAAATTGATGGGTAAATGTTATCACCTAAGCACTTCTAGAATGTCTGAAGTACAA
ACATGAAAAACAAACAAAAAAATTAACCGAGACACTTTATATGGCCCTGCACAGACCTGG
AGCGCCACACACTGCACATCTTTTGGTGATCGGGGTCAGGCAAAGGAGGGGAAACAATGA
AAACAAATAAAAGTTGAACTTGTTTTTCTCATGAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAA
5' Read Nucleotide Sequence
>OriGene 5' read for NM_134261 unedited
NNNNGGTTGAGATTTGTAAACGACTTATATAGGCGGCGCGCGAATTCGCACGAGGGCAAA
AAACATGGAGTCAGCTCCGGCAGCCCCCGACCCCGCCGCCAGCGAGCCAGGCAGCAGCGG
CGCGGACGCGGCCGCCGGCTCCAGGGAGACCCCGCTGAACCAGGAATCCGCCCGCAAGAG
CGAGCCGCCTGCCCCGGTGCGCAGACAGAGCTATTCCAGCACCAGCAGAGGTATCTCAGT
AACGAAGAAGACACATACATCTCAAATTGAAATTATTCCATGCAAGATCTGTGGAGACAA
ATCATCAGGAATCCATTATGGTGTCATTACATGTGAAGGCTGCAAGGGCTTTTTCAGGAG
AAGTCAGCAAAGCAATGCCACCTACTCCTGTCCTCGTCAGAAGAACTGTTTGATTGATCG
AACCAGTAGAAACCGCTGCCAACACTGTCGATTACAGAAATGCCTTGCCGTAGGGATGTC
TCGAGATGCTGTAAAATTTGGCCGAATGTCAAAAAAGCAGAGAGACAGCTTGTATGCAGA
AGTACAGAAACACCGGATGCAGCAGCAGCAGCGCGACCACCAGCAGCAGCCTGGAGAGGC
TGAGCCGCTGACGCCCACCTACAACATCTCGGCCAACGGGCTGACGGAACTTCACGACGA
CCTCAGTAACTACATTGACGGGCACACCCCTGAGGGGAGTAAGGCAGACTCCGCCGTCAG
CAGCTTCTACCTGGACATACAGCCTTCCCCAGACCAGTCAGGTCTTGATATCAATGGAAT
CAAACCAGAACCAATATGTGACTACACACCAGCATCAGGCTTCTTTCCNTACTGGTCGTT
CACCAACGGCGAGACTTCCNCACTGTGTCCATGGCAGAATAGNACACCTTGCACAGAATA
TATCTAAATCGCATCA
Restriction Sites Please inquire |
ACCN NM_134261
Insert Size 1816 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_134261.1, NP_599023.1
RefSeq Size 1847 bp
RefSeq ORF 1572 bp
Locus ID 6095
UniProt ID P35398
Cytogenetics 15q22.2
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Summary The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. provided by RefSeq, Feb 2014
Transcript Variant: This variant (1), also called RORalpha1, utilizes a different 5' exon than the other variants and encodes isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.
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Documents
Resources
"NM_134261" in other vectors (6)
SKU Description Size Price
RC202926 RORA (Myc-DDK-tagged)-Human RAR-related orphan receptor A (RORA), transcript variant 1 10 ug
$487.00
RC202926L1 Lenti ORF clone of Human RAR-related orphan receptor A (RORA), transcript variant 1, Myc-DDK-tagged 10 ug
$787.00
RC202926L2 Lenti ORF clone of Human RAR-related orphan receptor A (RORA), transcript variant 1, mGFP tagged 10 ug
$787.00
RC202926L3 Lenti ORF clone of Human RAR-related orphan receptor A (RORA), transcript variant 1, Myc-DDK-tagged 10 ug
$787.00
RC202926L4 Lenti ORF clone of Human RAR-related orphan receptor A (RORA), transcript variant 1, mGFP tagged 10 ug
$787.00
RG202926 RORA (tGFP-tagged) - Human RAR-related orphan receptor A (RORA), transcript variant 1 10 ug
$489.00 $687.00

file-alt Citations

Regulation of murine hepatic hydroxysteroid sulfotransferase expression in hyposulfatemic mice and in a cell model of 3'-phosphoadenosine-5'-phosphosulfate deficiency
Barrett, Fang, Gargano et al
Drug Metab. Dispos. (2013) 41 (8), 1505-13 DOI: 10.1124/dmd.113.051912
Cited by 6
AI Summary: In this study, the OriGene product RORα1/pCMV6-XL5 plasmid was used to investigate the role of the RORα1 nuclear receptor in regulating Sult2a1 promoter activity in cell-based reporter assays.
Snippet: nuclear receptor-responsive or Sult2a1 firefly luciferase reporter plasmid, 150 ng pGL3- Promoter (Promega), 50 ng of pcDNA3.1 (Life Technologies), 50 ng RORα1/pCMV6-XL5 (Origene, Rockville, MD), 1 ng pRL-CMV or pRL-SV40 (Promega), and sufficient pBluescript II
Cholesterol sulfate induces expression of the skin barrier protein filaggrin in normal human epidermal keratinocytes through induction of RORα
Hanyu, Nakae, Miida et al
Biochem. Biophys. Res. Commun. (2012) 428 (1), 99-104 DOI: 10.1016/j.bbrc.2012.10.013
Cited by 38
AI Summary: OriGene’s human RORα1 cDNA expression vector (catalog number not fully specified) was used in this study to generate RORα expression constructs for investigating the role of RORα in cholesterol sulfate-induced filaggrin expression in human keratinocytes.
Snippet: RORα expression vectors were generated by subcloning cDNAs for human RORα1 (Origene;cat. no. ... 4B, PD0-5), they retained significant luciferase activity as long as the AP-1-binding site was preserved. Both keratinocytes and HeLa cells express AP-1 [21] and [22].
Regulatory function of conserved sequences upstream of the long-wave sensitive opsin genes in teleost fishes
Tam, Watson, Massah et al
Vision Res. (2011) 51 (21-22), 2295-303 DOI: 10.1016/j.visres.2011.09.010
Cited by 13
AI Summary: OriGene’s Homo sapiens RORα (SC123126NM_134261) plasmid was used for co-transfection experiments to assess the regulatory effects of transcription factors on long-wave sensitive opsin gene expression in teleost fishes.
Snippet: Lasergene, DNASTAR). Homo sapiens RORα (OriGene: SC123126NM_134261), and the murine TRβ2 (in pcDNA3) were used for co-transfection experiments. Full-size image (166 K) Full-size image (166 K) Fig. 1. Alignment
Showing 1-3 of 3 papers.
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