NPTX2 (NM_002523) Human Untagged Clone
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | NPTX2 |
| Synonyms | NARP; NP-II; NP2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_002523 |
| Insert Size | 1296 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002523.1, NP_002514.1 |
| RefSeq Size | 2746 bp |
| RefSeq ORF | 1296 bp |
| Locus ID | 4885 |
| UniProt ID | P47972 |
| Cytogenetics | 7q22.1 |
| Protein Families | Secreted Protein |
| Summary | This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. provided by RefSeq, Feb 2009 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002523" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC206713 | NPTX2 (Myc-DDK-tagged)-Human neuronal pentraxin II (NPTX2) | 10 ug |
$457.00
|
|
| RC206713L1 | Lenti ORF clone of Human neuronal pentraxin II (NPTX2), Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC206713L2 | Lenti ORF clone of Human neuronal pentraxin II (NPTX2), mGFP tagged | 10 ug |
$757.00
|
|
| RC206713L3 | Lenti ORF clone of Human neuronal pentraxin II (NPTX2), Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC206713L4 | Lenti ORF clone of Human neuronal pentraxin II (NPTX2), mGFP tagged | 10 ug |
$757.00
|
|
| RG206713 | NPTX2 (tGFP-tagged) - Human neuronal pentraxin II (NPTX2) | 10 ug |
$489.00
$657.00
|
|
Citations
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
Hruska-Plochan, Wiersma, Betz et al
Nature (2024) 626 (8001), 1073-1083 DOI: 10.1038/s41586-024-07042-7
Hruska-Plochan, Wiersma, Betz et al
Nature (2024) 626 (8001), 1073-1083 DOI: 10.1038/s41586-024-07042-7
Cited by 63
AI Summary: OriGene’s NPTX2 ORF (catalog number SC122629) was used to generate expression constructs for studying the effects of NPTX2 overexpression in human neural network models, enabling the investigation of its neurotoxic role in TDP-43 proteinopathies described in the study.
Snippet: 1α promoter from custom synthetic sequence from GenScript was cloned into mTREAuto-TDP-43–HA vector substituting TRE promoter, generating pLVX-EF‐1α-TDP-43–HA vector. Then either NPTX2 ORF (Origene SC122629) or wild-type FUS27 was cloned into pLVX-EF‐1α-TDP-43–HA vector, substituting TDP-43–HA, generating pLVX-EF‐1α-NPTX2–HA and pLVX-EF‐1α-HA-FUS vectors. Then the full-l
The NPTX2-PTEN-NFkB nexus is an essential component of a prognostic DNA methylation signature of glioblastoma
Shukla, Patric, Thinagararajan et al
Cancer Res. (2013)
Shukla, Patric, Thinagararajan et al
Cancer Res. (2013)
AI Summary: OriGene’s pCMV-Entry/NPTX2 plasmid was used in this study to overexpress NPTX2 in glioma cells, enabling the authors to investigate its role in apoptosis, proliferation, chemosensitivity, and NFkB pathway regulation in glioblastoma.
Snippet: pathway. Page 4. 4 Materials and methods Plasmids and reporter constructs pCMV-Entry/NPTX2 was obtained from Origene. CAPI3K (pCDNA3-CD2p110myc) was described before (15, 16). CAAKT (pCDNA MYR HA AKT1) was from Addgene (Plasmid 9008).
Showing 1-2 of 2 papers.
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