Integrin alpha 6 (ITGA6) (NM_000210) Human Untagged Clone

CAT#: SC120055

ITGA6 (untagged)-Human integrin, alpha 6 (ITGA6), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Integrin alpha 6
• Synonyms: CD49f; ITGA6B; VLA-6
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_000210 edited
  GGGCGGCCCGCGAATTCGGCACCAGGGCCGCTGCAGGTCCCCGCTCCCCTCCCCGTGCGT
  CCGCCCATGGCCGCCGCCGGGCAGCTGTGCTTGCTCTACCTGTCGGCGGGGCTCCTGTCC
  CGGCTCGGCGCAGCCTTCAACTTGGACACTCGGGAGGACAACGTGATCCGGAAATATGGA
  GACCCCGGGAGCCTCTTCGGCTTCTCGCTGGCCATGCACTGGCAACTGCAGCCCGAGGAC
  AAGCGGCTGTTGCTCGTGGGGGCCCCGCGGGCAGAAGCGCTTCCACTGCAGAGAGCCAAC
  AGAACGGGAGGGCTGTACAGCTGCGACATCACCGCCCGGGGGCCATGCACGCGGATCGAG
  TTTGATAACGATGCTGACCCCACGTCAGAAAGCAAGGAAGATCAGTGGATGGGGGTCACC
  GTCCAGAGCCAAGGTCCAGGGGGCAAGGTCGTGACATGTGCTCACCGATATGAAAAAAGG
  CAGCATGTTAATACGAAGCAGGAATCCCGAGACATCTTTGGGCGGTGTTATGTCCTGAGT
  CAGAATCTCAGGATTGAAGACGATATGGATGGGGGAGATTGGAGCTTTTGTGATGGGCGA
  TTGAGAGGCCATGAGAAATTTGGCTCTTGCCAGCAAGGTGTAGCAGCTACTTTTACTAAA
  GACTTTCATTACATTGTATTTGGAGCCCCGGGTACTTATAACTGGAAAGGGATTGTTCGT
  GTAGAGCAAAAGAATAACACTTTTTTTGACATGAACATCTTTGAAGATGGGCCTTATGAA
  GTTGGTGGAGAGACTGAGCATGATGAAAGTCTCGTTCCTGTTCCTGCTAACAGTTACTTA
  GGTTTTTCTTTGGACTCAGGGAAAGGTATTGTTTCTAAAGATGAGATCACTTTTGTATCT
  GGTGCTCCCAGAGCCAATCACAGTGGAGCCGTGGTTTTGCTGAAGAGAGACATGAAGTCT
  GCACATCTCCTCCCTGAGCACATATTCGATGGAGAAGGTCTGGCCTCTTCATTTGGCTAT
  GATGTGGCGGTGGTGGACCTCAACAAGGATGGGTGGCAAGATATAGTTATTGGAGCCCCA
  CAGTATTTTGATAGAGATGGAGAAGTTGGAGGTGCAGTGTATGTCTACATGAACCAGCAA
  GGCAGATGGAATAATGTGAAGCCAATTCGTCTTAATGGAACCAAAGATTCTATGTTTGGC
  ATTGCAGTAAAAAATATTGGAGATATTAATCAAGATGGCTACCCAGATATTGCAGTTGGA
  GCTCCGTATGATGACTTGGGAAAGGTTTTTATCTATCATGGATCTGCAAATGGAATAAAT
  ACCAAACCAACACAGGTTCTCAAGGGTATATCACCTTATTTTGGATATTCAATTGCTGGA
  AACATGGACCTTGATCGAAATTCCTACCCTGATGTTGCTGTTGGTTCCCTCTCAGATTCA
  GTAACTATTTTCAGATCCCGGCCTGTGATTAATATTCAGAAAACCATCACAGTAACTCCT
  AACAGAATTGACCTCCGCCAGAAAACAGCGTGTGGGGCGCCTAGTGGGATATGCCTCCAG
  GTTAAATCCTGTTTTGAATATACTGCTAACCCCGCTGGTTATAATCCTTCAATATCAATT
  GTGGGCACACTTGAAGCTGAAAAAGAAAGAAGAAAATCTGGGCTATCCTCAAGAGTTCAG
  TTTCGAAACCAAGGTTCTGAGCCCAAATATACTCAAGAACTAACTCTGAAGAGGCAGAAA
  CAGAAAGTGTGCATGGAGGAAACCCTGTGGCTACAGGATAATATCAGAGATAAACTGCGT
  CCCATTCCCATAACTGCCTCAGTGGAGATCCAAGAGCCAAGCTCTCGTAGGCGAGTGAAT
  TCACTTCCAGAAGTTCTTCCAATTCTGAATTCAGATGAACCCAAGACAGCTCATATTGAT
  GTTCACTTCTTAAAAGAGGGATGTGGAGACGACAATGTATGTAACAGCAACCTTAAACTA
  GAATATAAATTTTGCACCCGAGAAGGAAATCAAGACAAATTTTCTTATTTACCAATTCAA
  AAAGGTGTACCAGAACTAGTTCTAAAAGATCAGAAGGATATTGCTTTAGAAATAACAGTG
  ACAAACAGCCCTTCCAACCCAAGGAATCCCACAAAAGATGGCGATGACGCCCATGAGGCT
  AAACTGATTGCAACGTTTCCAGACACTTTAACCTATTCTGCATATAGAGAACTGAGGGCT
  TTCCCTGAGAAACAGTTGAGTTGTGTTGCCAACCAGAATGGCTCGCAAGCTGACTGTGAG
  CTCGGAAATCCTTTTAAAAGAAATTCAAATGTCACTTTTTATTTGGTTTTAAGTACAACT
  GAAGTCACCTTTGACACCCCAGATCTGGATATTAATCTGAAGTTAGAAACAACAAGCAAT
  CAAGATAATTTGGCTCCAATTACAGCTAAAGCAAAAGTGGTTATTGAACTGCTTTTATCG
  GTCTCGGGAGTTGCTAAACCTTCCCAGGTGTATTTTGGAGGTACAGTTGTTGGCGAGCAA
  GCTATGAAATCTGAAGATGAAGTGGGAAGTTTAATAGAGTATGAATTCAGGGTAATAAAC
  TTAGGTAAACCTCTTACAAACCTCGGCACAGCAACCTTGAACATTCAGTGGCCAAAAGAA
  ATTAGCAATGGGAAATGGTTGCTTTATTTGGTGAAAGTAGAATCCAAAGGATTGGAAAAG
  GTAACTTGTGAGCCACAAAAGGAGATAAACTCCCTGAACCTAACGGAGTCTCACAACTCA
  AGAAAGAAACGGGAAATTACTGAAAAACAGATAGATGATAACAGAAAATTTTCTTTATTT
  GCTGAAAGAAAATACCAGACTCTTAACTGTAGCGTGAACGTGAACTGTGTGAACATCAGA
  TGCCCGCTGCGGGGGCTGGACAGCAAGGCGTCTCTTATTTTGCGCTCGAGGTTATGGAAC
  AGCACATTTCTAGAGGAATATTCCAAACTGAACTACTTGGACATTCTCATGCGAGCCTTC
  ATTGATGTGACTGCTGCTGCCGAAAATATCAGGCTGCCAAATGCAGGCACTCAGGTTCGA
  GTGACTGTGTTTCCCTCAAAGACTGTAGCTCAGTATTCGGGAGTACCTTGGTGGATCATC
  CTAGTGGCTATTCTCGCTGGGATCTTGATGCTTGCTTTATTAGTGTTTATACTATGGAAG
  TGTGGTTTCTTCAAGAGAAATAAGAAAGATCATTATGATGCCACATATCACAAGGCTGAG
  ATCCATGCTCAGCCATCTGATAAAGAGAGGCTTACTTCTGATGCATAGTATTGATCTACT
  TCTGTAATTGTGTGGATTCTTTAAACGCTCTAGGTACGATGACAGTGTTCCCCGATACCA
  TGCTGTAAGGATCCGGAAAGAAGAGCGAGAGATCAAAGATGAAAAGTATATTGATAACCT
  TGAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000210 unedited
  TGTGCGAATTTTGTAATACGACTCACTATAGGGCGGCCCGCGATTCGGCACCAGGCCGCT
  GCAGGTCCCCGCTCCCCTCCCCGTGCGTCCGCCCATGGCCGCCGCCGGGCAGCTGTGCTT
  GCTCTACCTGTCACTCGGGGCTCCTGTCCCGGCTCGGCGCAGCCTTCAACTTGGACACTC
  GGGAGGACAACGTGATCCGGAAATATGGAGACCCCGGGAGCCTCTTCGGCTTCTCGCTGG
  CCATGCACTGGCAACTGCAGCCCGAGGACAAGCGGCTGTTGCTCGTGGGGGCCCCGCGGG
  CAGAAGCGCTTCCACTGCAGAGAGCCAACAGAACGGGAGGGCTGTACAGCTGCGACACTA
  CCGCCCGGGGGCTCATGCACGCGGATCGAGTTTGATAACGATGCTGACCCCACGTCAGAA
  AGCAAGGAAGATCAGTGGATGGGGGTCACCGTCCAGAGCCAAGGTCCAGGGGGCAAGGTC
  GTGACATGTGCTCACCGATATGAAAAAAGGCAGCATGTTAATACGAAGCAGGAATCCCGA
  GACATCTTTGGGCGGTGTTATGTCCTGAGTCAGAATCTCAGGATTGAAGACGATATGGAT
  GGGGGAGATTGGAGCTTTTGTGATGGGCGATTGAGAGGCCATGAGAAATTTGGCTCTTGC
  CAGCAAGGTGTAACAGCTACTTTTACTAAAGACTTTCATTACATTGTATTTGGAGCCCCG
  GTACTTACTACTGGAAAGGGATGTTCGTGTAGAGCACAAGAATACCACTTTTTTGCCATG
  AACATCTTTTGAGATGGGCCTTATGAATTTGGTGGAGAGACTGAGCATGATGAAAGTCTC
  GGTCCTGTTCCTGCTAACAGTACTTAGGTTTTCCTTGCACTCAGGCAAGGCATTGTTTCT
  AAAGATGAGACACCTTTTGAATCTGGGGCTCCCAGAACCCATCCAGTGCAGC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000210 unedited
  NAACCCCGGGAANAAACCCCCCAACCATCCCCCAAAATNNTTGACTGTGCNCNCCGGCCC
  GCTATTCTNANGATCGNGTTTTTTTTTTTTTTTTTTTAACTTTTATAAAAAATTATTTCA
  CACTTTTATACAAATATCCACAGGTAATTTCTAATCATGAAATAATTTTACAATGCTAGT
  TAGTACAAAAATGTATCAAATGCAAACAGACCAGTGACTTGACTTGAGATGACATTTTTA
  ACAACCATAAATCTAAACACCATAACATCTTTGTTTCTTTGTTGAACCACCCTCCCAACA
  CCCTTTTCAGGACATTCATCTTTTTTTTAGCAACACAGGTCTAAAAACACTGTCAAAGTA
  TCCAGTTCCTTACCAATCTACTAATCTACACCACATTAGGGACACAAGCTCCCCCATCAA
  GAAACTGACACTTCAAACACTGTTATAACCTGTTTTACCGCACCTCTCGCAAACCATCTA
  CCTTTCCCGACTAATACTTCTACCCTTCTACCCAAACAACTCCCTTTGCTTCTTACCGCT
  TTTCATTCCCCGAAATTATAAACCCCTTTCTCACTTACCCCTTGCCTCTCTTCCCGCTCC
  CCTCCCCTTCCCATGTTCTCCCCCACGTCCTCACCACACCCAATTATTCCCCCCATTATT
  TCGCCCTTTCCCCCCCACTCCCCCCCCCCTCTTCCCCCCCTTTCCCTCACCCCCCCCCCC
  CCTTTTCCTCCTATTTTCCCAATTTCCCTCCCTTCCCCTATTTTTCCCCCTCCCTTCCTC
  CGCTTCCCTTCCCCGATTCCCCTCTTCGTCTCCATCCCTCACCCTCTACCACCTCTTCCA
  CCACCCCCCTCGCTCTTCACCCACCTATCTTCTCCCTCCCTCCCCCCCTCCTCCCTTCTC
  CTTCCCCCCTCCCCCTCCCTCCTCCCTTATTTCCCCTTCCCTTTTTTTCCCCTTCTCCTT
  CGCCCTCCTTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_000210
• Insert Size: 4730 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000210.1, NP_000201.1
• RefSeq Size: 5611 bp
• RefSeq ORF: 3222 bp
• Locus ID: 3655
• UniProt ID: P23229
• Cytogenetics: 2q31.1
• Domains: FG-GAP
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer
• Gene Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
  Transcript Variant: This variant (2) contains an alternate coding exon compared to variant 1, which results in a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.