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Factor I (CFI) (NM_000204) Human Untagged Clone

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SKU
SC120051
CFI (untagged)-Human complement factor I (CFI)
  $544.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol Factor I
Synonyms AHUS3; ARMD13; C3b-INA; C3BINA; FI; IF; KAF
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC120051 sequence for NM_000204 edited (data generated by NextGen Sequencing)
ATGAAGCTTCTTCATGTTTTCCTGTTATTTCTGTGCTTCCACTTAAGGTTTTGCAAGGTC
ACTTATACATCTCAAGAGGATCTGGTGGAGAAAAAGTGCTTAGCAAAAAAATATACTCAC
CTCTCCTGCGATAAAGTCTTCTGCCAGCCATGGCAGAGATGCATTGAGGGCACCTGTGTT
TGTAAACTACCGTATCAGTGCCCAAAGAATGGCACTGCAGTGTGTGCAACTAACAGGAGA
AGCTTCCCAACATACTGTCAACAAAAGAGTTTGGAATGTCTTCATCCAGGGACAAAGTTT
TTAAATAACGGAACATGCACAGCCGAAGGAAAGTTTAGTGTTTCCTTGAAGCATGGAAAT
ACAGATTCAGAGGGAATAGTTGAAGTAAAACTTGTGGACCAAGATAAGACAATGTTCATA
TGCAAAAGCAGCTGGAGCATGAGGGAAGCCAACGTGGCCTGCCTTGACCTTGGGTTTCAA
CAAGGTGCTGATACTCAAAGAAGGTTTAAGTTGTCTGATCTCTCTATAAATTCCACTGAA
TGTCTACATGTGCATTGCCGAGGATTAGAGACCAGTTTGGCTGAATGTACTTTTACTAAG
AGAAGAACTATGGGTTACCAGGATTTCGCTGATGTGGTTTGTTATACACAGAAAGCAGAT
TCTCCAATGGATGACTTCTTTCAGTGTGTGAATGGGAAATACATTTCTCAGATGAAAGCC
TGTGATGGTATCAATGATTGTGGAGACCAAAGTGATGAACTGTGTTGTAAAGCATGCCAA
GGCAAAGGCTTCCATTGCAAATCAGGTGTTTGCATTCCAAGCCAGTATCAATGCAATGGT
GAGGTGGACTGCATTACAGGGGAAGATGAAGTTGGCTGTGCAGGCTTTGCATCTGTGGCT
CAAGAAGAAACAGAAATTTTGACTGCTGACATGGATGCAGAAAGAAGACGGATAAAATCA
TTATTACCTAAACTATCTTGTGGAGTTAAAAACAGAATGCACATTCGAAGGAAACGAATT
GTGGGAGGAAAGCGAGCACAACTGGGAGACCTCCCATGGCAGGTGGCAATTAAGGATGCC
AGTGGAATCACCTGTGGGGGAATTTATATTGGTGGCTGTTGGATTCTGACTGCTGCACAT
TGTCTCAGAGCCAGTAAAACTCATCGTTACCAAATATGGACAACAGTAGTAGACTGGATA
CACCCCGACCTTAAACGTATAGTAATTGAATACGTGGATAGAATTATTTTCCATGAAAAC
TACAATGCAGGCACTTACCAAAATGACATCGCTTTGATTGAAATGAAAAAAGACGGAAAC
AAAAAAGATTGTGAGCTGCCTCGTTCCATCCCTGCCTGTGTCCCCTGGTCTCCTTACCTA
TTCCAACCTAATGATACATGCATCGTTTCTGGCTGGGGACGAGAAAAAGATAACGAAAGA
GTCTTTTCACTTCAGTGGGGTGAAGTTAAACTAATAAGCAACTGCTCTAAGTTTTACGGA
AATCGTTTCTATGAAAAAGAAATGGAATGTGCAGGTACATATGATGGTTCCATCGATGCC
TGTAAAGGGGACTCTGGAGGCCCCTTAGTCTGTATGGATGCCAACAATGTGACTTATGTC
TGGGGTGTTGTGAGTTGGGGGGAAAACTGTGGAAAACCAGAGTTCCCAGGTGTTTACACC
AAAGTGGCCAATTATTTTGACTGGATTAGCTACCATGTAGGAAGGCCTTTTATTTCTCAG
TACAATGTATAA

Clone variation with respect to NM_000204.3
804 g=>a
5' Read Nucleotide Sequence
>OriGene 5' read for NM_000204 unedited
NGGGGTCACCATTTGTATACGACTCCTATAGGCGGCCCGCGAATTCGCACCAGNAGAAAA
ANACCCCGACACCTCCAACATGAACTTCTTCATGTTTTCCTGTTATTTCTGTGCTTCCAC
TTAAGGTTTTGCAAGGTCACTTATACATCTCAAGAGGATCTGGTGGAGAAAAAGTGCTTA
GCAAAAAAATATACTCACCTCTCCTGCGATAAAGTCTTCTGCCAGCCATGGCAGAGATGC
ATTGAGGGCACCTGTGTTTGTAAACTACCGTATCAGTGCCCAAAGAATGGCACTGCAGTG
TGTGCAACTAACAGGAGAAGCTTCCCAACATACTGTCAACAAAAGAGTTTGGAATGTCTT
CATCCAGGGACAAAGTTTTTAAATAACGGAACATGCACAGCCGAAGGAAAGTTTAGTGTT
TCCTTGAAGCATGGAAATACAGATTCAGAGGGAATAGTTGAAGTAAAACTTGTGGACCAA
GATAAGACAATGTTCATATGCAAAAGCAGCTGGAGCATGAGGGAAGCCAACGTGGCCTGC
CTTGACCTTGGGTTTCAACAAGGTGCTGATACTCAAAGAAGGTTTAAGTTGTCTGATCTC
TCTATAAATTCCACTGAATGTCTACATGTGCATTGCCGAGGATTAGAGACCAGTTTGGCT
GAATGTACTTTTACTAAGAGAAGAACTATGGGTTACCAGGATTTCGCTGATGTGGTTTTG
TTATACACAGAAAGCAGATTCTCCAATGGATGACTTCTTTCAGTGTGTGAATGGGAAATA
CATTTCTCAGATGAAAGCCTGTGATGTTATCAATGATTGTGGAGACCAAATGATGAACTG
TGTTGTAAACATGCCAAGGCAAAGCTTCCATTGCAAATAGGGGTTTGCATTCCAGCA
3' Read Nucleotide Sequence
>OriGene 3' read for NM_000204 unedited
NTTTAGCTTGNACCCGCGGCCGCATNCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTT
TATGCTTCACCAAANATATTTATTTGAGAATTATACAACAAAATTCCAATATGGCATAAA
CTCTGTGGAGACCTTTAAAAATATCCAATGAGATTTGCTTCATTTTTCCCCCCTAGAGAA
TTATTAATTATACCGTTTTATTTCCATTAAATGGAACTCTTGAGAGAAAAAGAATAGAAT
GAAGAGAGAGATCACAATTTTATACATTGTACTGAGAAATAAAAGGCCTTCCTACATGGT
AGCTAATCCAGTCAAAATAATTGGCCACTTTGGTGTAAACACCTGGGAACTCTGGTTTTC
CACAGTTTTCCCCCCAACTCACAACACCCCAGACATAAGTCACATTGTTGGCATCCATAC
AGACTAAGGGGCCTCCAGAGTCCCCTTTACAGGCATCGATGGAACCATCATATGTACCTG
CACATTCCATTTCTTTTTCATAGAAACGATTTCCGTAAAACTTAGAGCAGTTGCTTATTA
GTTTAACTTCACCCCACTGAAGTGAAAAGACTCTTTCGTTATCTTTTTCTCGTCCCCAGC
CAGAAACGATGCATGTATCATTAGGTTGGAATAGGTAAGGAGACCAGGGGACACAGGCAG
GGATGGAACGAGGCAGCTCACAATCTTTTTTGTTTCCGTCTTTTTTCATTTCAATCAAAG
CGATGTCATTTTGGTAAGTGCCTGCATTGTAGTTTTCATGGAAAATAATTCTATCCACGT
ATTCAATTACTATACGTTTAAGGTCGGGGTGTATCCAGTCTACTACTGTTGTCCATATTT
GGTACGATGAGTTTTACTGGCTCTGAGNACATGTGCAGCAGTCAGAATCCACAGCCACCC
ATATAAATCCCCACAGGTGATNCACTGGCATNCTTAATGCCCCTGCATGGAA
Restriction Sites NotI-NotI |
ACCN NM_000204
Insert Size 2260 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_000204.1, NP_000195.1
RefSeq Size 1963 bp
RefSeq ORF 1752 bp
Locus ID 3426
UniProt ID P05156
Cytogenetics 4q25
Domains FIMAC, ldl_recept_a, SR, Tryp_SPc
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades
Summary This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. provided by RefSeq, Dec 2015
Transcript Variant: This variant (2) encodes isoform 2.
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Documents
Resources
"NM_000204" in other vectors (6)
SKU Description Size Price
RC216645 CFI (Myc-DDK-tagged)-Human complement factor I (CFI) 10 ug
$543.00
RC216645L1 Lenti ORF clone of Human complement factor I (CFI), Myc-DDK-tagged 10 ug
$843.00
RC216645L2 Lenti ORF clone of Human complement factor I (CFI), mGFP tagged 10 ug
$843.00
RC216645L3 Lenti ORF clone of Human complement factor I (CFI), Myc-DDK-tagged 10 ug
$843.00
RC216645L4 Lenti ORF clone of Human complement factor I (CFI), mGFP tagged 10 ug
$843.00
RG216645 CFI (tGFP-tagged) - Human complement factor I (CFI) 10 ug
$489.00 $743.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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