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Methylmalonyl Coenzyme A mutase (MUT) (NM_000255) Human Untagged Clone

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SKU
SC120001
MUT (untagged)-Human methylmalonyl CoA mutase (MUT), nuclear gene encoding mitochondrial protein
  $688.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol Methylmalonyl Coenzyme A mutase
Synonyms MCM; MUT
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC120001 sequence for NM_000255 edited (data generated by NextGen Sequencing)
ATGTTAAGAGCTAAGAATCAGCTTTTTTTACTTTCACCTCATTACCTGAGGCAGGTAAAA
GAATCATCAGGCTCCAGGCTCATACAGCAACGACTTCTACACCAGCAACAGCCCCTTCAC
CCAGAATGGGCTGCCCTGGCTAAAAAGCAGCTGAAAGGCAAAAACCCAGAAGACCTAATA
TGGCACACCCCGGAAGGGATCTCTATAAAACCCTTGTATTCCAAGAGAGATACTATGGAC
TTACCTGAAGAACTTCCAGGAGTGAAGCCATTCACACGTGGACCATATCCTACCATGTAT
ACCTTTAGGCCCTGGACCATCCGCCAGTATGCTGGTTTTAGTACTGTGGAAGAAAGCAAT
AAGTTCTATAAGGACAACATTAAGGCTGGTCAGCAGGGATTATCAGTTGCCTTTGATCTG
GCGACACATCGTGGCTATGATTCAGACAACCCTCGAGTTCGTGGTGATGTTGGAATGGCT
GGAGTTGCTATTGACACTGTGGAAGATACCAAAATTCTTTTTGATGGAATTCCTTTAGAA
AAAATGTCAGTTTCCATGACTATGAATGGAGCAGTTATTCCAGTTCTTGCAAATTTTATA
GTAACTGGAGAAGAACAAGGTGTACCTAAAGAGAAGCTTACTGGTACCATCCAAAATGAT
ATACTAAAGGAATTTATGGTTCGAAATACATACATTTTTCCTCCAGAACCATCCATGAAA
ATTATTGCTGACATATTTGAATATACAGCAAAGCACATGCCAAAATTTAATTCAATTTCA
ATTAGTGGATACCATATGCAGGAAGCAGGGGCTGATGCCATTCTGGAGCTGGCCTATACT
TTAGCAGATGGATTGGAGTACTCTAGAACTGGACTCCAGGCTGGCCTGACAATTGATGAA
TTTGCACCAAGGTTGTCTTTCTTCTGGGGAATTGGAATGAATTTCTATATGGAAATAGCA
AAGATGAGAGCTGGTAGAAGACTCTGGGCTCACTTAATAGAGAAAATGTTTCAGCCTAAA
AACTCAAAATCTCTTCTTCTAAGAGCACACTGTCAGACATCTGGATGGTCACTTACTGAG
CAGGATCCCTACAATAATATTGTCCGTACTGCAATAGAAGCAATGGCAGCAGTATTTGGA
GGGACTCAGTCTTTGCACACAAATTCTTTTGATGAAGCTTTGGGTTTGCCAACTGTGAAA
AGTGCTCGAATTGCCAGGAACACACAAATCATCATTCAAGAAGAATCTGGGATTCCCAAA
GTGGCTGATCCTTGGGGAGGTTCTTACATGATGGAATGTCTCACAAATGATGTTTATGAT
GCTGCTTTAAAGCTCATTAATGAAATTGAAGAAATGGGTGGAATGGCCAAAGCTGTAGCT
GAGGGAATACCTAAACTTCGAATTGAAGAATGTGCTGCCCGAAGACAAGCTAGAATAGAT
TCTGGTTCTGAAGTAATTGTTGGAGTAAATAAGTACCAGTTGGAAAAAGAAGACGCTGTA
GAAGTTCTGGCAATTGATAATACTTCAGTGCGAAACAGGCAGATTGAAAAACTTAAGAAG
ATCAAATCCAGCAGGGATCAAGCTTTGGCTGAACGTTGTCTTGCTGCACTAACCGAATGT
GCTGCTAGCGGAGATGGAAATATCCTGGCTCTTGCAGTGGATGCATCTCGGGCAAGATGT
ACAGTGGGAGAAATCACAGATGCCCTGAAAAAGGTATTTGGTGAACATAAAGCGAATGAT
CGAATGGTGAGTGGAGCATATCGCCAGGAATTTGGAGAAAGTAAAGAGATAACATCTGCT
ATCAAGAGGGTTCATAAATTCATGGAACGTGAAGGTCGCAGACCTCGTCTTCTTGTAGCA
AAAATGGGACAAGATGGCCATGACAGAGGAGCAAAAGTTATTGCTACAGGATTTGCTGAT
CTTGGTTTTGATGTGGACATAGGCCCTCTTTTCCAGACTCCTCGTGAAGTGGCCCAGCAG
GCTGTGGATGCGGATGTGCATGCTGTGGGCATAAGCACCCTCGCTGCTGGTCATAAAACC
CTAGTTCCTGAACTCATCAAAGAACTTAACTCCCTTGGACGGCCAGATATTCTTGTCATG
TGTGGAGGGGTGATACCACCTCAGGATTATGAATTTCTGTTTGAAGTTGGTGTTTCCAAT
GTATTTGGTCCTGGGACTCGAATTCCAAAGGCTGCCGTTCAGGTGCTTGATGATATTGAG
AAGTGTTTGGAAAAGAAGCAGCAATCTGTATAA

Clone variation with respect to NM_000255.3
5' Read Nucleotide Sequence
>OriGene 5' read for NM_000255 unedited
TGAAACACGACTTACTATAGGGCGGCCGCGAATTCGGCACGAGGCAGAGTCGTCCGGCTG
ACGCTGGCGGTGGCGCGGTTTGTGTGGGCTTGGTGAGGGCGGGGAGGCCTGGCTGTGTGG
ATGTCTGACAGGTGAGGCGGGGGACGCAGAAGTGCAGCCGCCCTCTCCCACAGCGGAGTC
CAAAACAGGCCTACCAGTCAGTTCTTATTTCTATTGGGTGTTTCCATGCTCCACCATGTT
AAGAGCTAAGAATCAGCTTTTTTTACTTTCACCTCATTACCTGAGGCAGGTAAAAGAATC
ATCAGGCTCCAGGCTCATACAGCAACGACTTCTACACCAGCAACAGCCCCTTCACCCAGA
ATGGGCTGCCCTGGCTAAAAAGCAGCTGAAAGGCAAAAACCCAGAAGACCTAATATGGCA
CACCCCGGAAGGGATCTCTATAAAACCCTTGTATTCCAAGAGAGATACTATGGACTTACC
TGAAGAACTTCCAGGAGTGAAGCCATTCACACGTGGACCATATCCTACCATGTATACCTT
TAGGCCCTGGACCATCCGCCAGTATGCTGGTTTTAGTACTGTGGAAGAAAGCAATAAGTT
CTATAAGGACAACATTAAGGCTGGTCAGCAGGGATTATCAGTTGCCTTTGATCTGGCGAC
ACATCGTGGCTATGATTCAGACAACCCTCGAGTTCGTGGTGATGTTGGAATGGCTGGAGT
TGCTATTGACACTGTGGAAGATACCAAAATTCTTTTTGATGGAATTCCTTTANAAAAAAT
GTCAGTTTCCATGACTATGAAATGGAGCAGTATTCCAGTTCTTGCAAATTNTATAGTAAC
TGGAGAAGAACAAGGTGTACCTAAAGAGAGCTTACTGGTACCATNCANATGAATACTNAA
GGATT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_000255 unedited
TGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGAAGTGAAACTGTAT
GTACATACTTATAGCATGACACCAGGCCTATAAGTAAGGTATTTTAAAGTAAAGCTTTCA
AGGAAAGTACAAATCAGGTATTGAAATTAAATTGAAGACATAGCTTTACTCTCTTCTTTG
ATCATAACTAAAATAATATTTTAGACAAAAGCTAAAACAAAAAGAGGATATTATACAGAT
TGCTGCTTCTTTTCCAAACACTTCTCAATATCATCAAGCACCTGAACGGCAGCCTTTGGA
ATTCGAGTCCCAGGACCAAATACATTGGAAACACCAACTTCAAACAGAAATTCATAATCC
TGAGGTGGTATCACCCCTCCACACATGACAAGAATATCTGGCCGTCCAAGGGAGTTAAGT
TCTTTGATGAGTTCAGGAACTAGGGTTTTATGACCAGCAGCGAGGGTGCTTATGCCCACA
GCATGCACATCCGCATCCACAGCCTGCTGGGCCACTTCACGAGGAGTCTGGAAAAGAGGG
CCTATGTCCACATCAAAACCAAGATCAGCAAATCCTGTAGCAATAACTTTTGCTCCTCTG
TCATGGCCATCTTGTCCCATTTTTGCTACAAGAAGACGAGGTCTGCGACCTTCACGTTCC
ATGAATTTATGAACCCTCTTGATAGCAGATGTTATCTCTTTACTTTCTCCAAATTCCTGG
CGATATGCTCCACTCACCATTCGATCATTCGCTTTATGTTCACCAAATACCTTTTTCAGG
GCATCTGTGATTTCTCCACTGTACATCTTGCCCGAGATGCATCCACTTGCAGAGCCAAGA
TTTTCCATCTCCGCTACCACCACATCCCGTTATTGCAGCAAGACAACGTTCAGCCAAGCT
TGATCCCTGCTGAAT
Restriction Sites NotI-NotI |
ACCN NM_000255
Insert Size 2710 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_000255.1, NP_000246.1
RefSeq Size 2798 bp
RefSeq ORF 2253 bp
Locus ID 4594
UniProt ID P22033
Cytogenetics 6p12.3
Domains B12-binding, MM_CoA_mutase
Protein Families Druggable Genome
Protein Pathways leucine and isoleucine degradation, Metabolic pathways, Propanoate metabolism, Valine
Summary This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria. provided by RefSeq, Jul 2008
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Documents
Resources
"NM_000255" in other vectors (6)
SKU Description Size Price
RC201972 MUT (Myc-DDK-tagged)-Human methylmalonyl CoA mutase (MUT), nuclear gene encoding mitochondrial protein 10 ug
$687.00
RC201972L1 Lenti ORF clone of Human methylmalonyl CoA mutase (MUT), nuclear gene encoding mitochondrial protein, Myc-DDK-tagged 10 ug
$987.00
RC201972L2 Lenti ORF clone of Human methylmalonyl CoA mutase (MUT), nuclear gene encoding mitochondrial protein, mGFP tagged 10 ug
$987.00
RC201972L3 Lenti ORF clone of Human methylmalonyl CoA mutase (MUT), nuclear gene encoding mitochondrial protein, Myc-DDK-tagged 10 ug
$987.00
RC201972L4 Lenti ORF clone of Human methylmalonyl CoA mutase (MUT), nuclear gene encoding mitochondrial protein, mGFP tagged 10 ug
$987.00
RG201972 MUT (tGFP-tagged) - Human methylmalonyl CoA mutase (MUT), nuclear gene encoding mitochondrial protein 10 ug
$789.00 $887.00

file-alt Citations

TAT-MTS-MCM fusion proteins reduce MMA levels and improve mitochondrial activity and liver function in MCM-deficient cells
Erlich-Hadad, Hadad, Feldman et al
J. Cell. Mol. Med. (2017)
AI Summary: OriGene contributed to this study by providing the MCM clone (Cat No SC120001), which was used as a template to generate full-length and MTS-deficient MCM constructs for the development and testing of TAT-MTS-MCM fusion proteins.
Snippet: The full-length MCM and the MCM lacking its native MTS were generated by PCR using a MCM clone [purchased from OriGene, Rockville, MD, USA, Cat No SC120001 (accession NM_000255)] as a template and a pair of primers covering the whole sequence, including
Showing 1-1 of 1 papers.
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