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GALNS (NM_000512) Human Untagged Clone

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SKU
SC119830
GALNS (untagged)-Human galactosamine (N-acetyl)-6-sulfate sulfatase (GALNS)
  $487.00
In Stock*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol GALNS
Synonyms GalN6S; GALNAC6S; GAS; MPS4A
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC119830 sequence for NM_000512 edited (data generated by NextGen Sequencing)
ATGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAGCTGTTGCTGGTGCTCAGCGCCGCG
GGGATGGGGGCCTCGGGCGCCCCGCAGCCCCCCAACATCCTGCTCCTGCTCATGGACGAC
ATGGGATGGGGTGACCTCGGGGTGTATGGAGAGCCCTCCAGAGAGACCCCGAATTTGGAC
CGGATGGCTGCAGAAGGGCTGCTTTTCCCAAACTTCTATTCTGCCAACCCTCTGTGCTCG
CCATCGAGGGCGGCACTGCTCACAGGACGGCTACCCATCCGCAATGGCTTCTACACCACC
AACGCCCATGCCAGAAACGCCTACACACCGCAGGAGATTGTGGGCGGCATCCCAGACTCG
GAGCAGCTCCTGCCGGAGCTTCTGAAGAAGGCCGGCTACGTCAGCAAGATTGTCGGCAAG
TGGCATCTGGGTCACAGGCCCCAGTTCCACCCCCTGAAGCACGGATTTGATGAGTGGTTT
GGATCCCCCAACTGCCACTTTGGACCTTATGACAACAAGGCCAGGCCCAACATCCCTGTG
TACAGGGACTGGGAGATGGTTGGCAGATATTATGAAGAATTTCCTATTAATCTGAAGACG
GGGGAAGCCAACCTCACCCAGATCTACCTGCAGGAAGCCCTGGACTTCATTAAGAGACAG
GCACGGCACCACCCCTTTTTCCTCTACTGGGCTGTCGACGCCACGCACGCACCCGTCTAT
GCCTCCAAACCCTTCTTGGGCACCAGTCAGCGAGGGCGGTATGGAGACGCCGTCCGGGAG
ATTGATGACAGCATTGGGAAGATACTGGAGCTCCTCCAAGACCTGCACGTCGCGGACAAC
ACCTTCGTCTTCTTCACGTCGGACAACGGCGCTGCCCTCATTTCCGCCCCCGAACAAGGT
GGCAGCAACGGCCCCTTTCTGTGTGGGAAGCAGACCACGTTTGAAGGAGGGATGAGGGAG
CCTGCCCTCGCATGGTGGCCAGGGCACGTCACTGCAGGCCAGGTGAGCCACCAGCTGGGC
AGCATCATGGACCTCTTCACCACCAGCCTGGCCCTTGCGGGCCTGACGCCGCCCAGCGAC
AGGGCCATTGATGGCCTCAACCTCCTCCCCACCCTCCTGCAGGGCCGGCTGATGGACAGG
CCTATCTTCTATTACCGTGGCGACACGCTGATGGCGGCCACCCTCGGGCAGCACAAGGCT
CACTTCTGGACCTGGACCAACTCCTGGGAGAACTTCAGACAGGGCATTGATTTCTGCCCT
GGGCAGAACGTTTCAGGGGTCACAACTCACAATCTGGAAGACCACACGAAGCTGCCCCTG
ATCTTCCACCTGGGACGGGACCCAGGGGAGAGGTTCCCCCTCAGCTTTGCCAGCGCCGAG
TACCAGGAGGCCCTCAGCAGGATCACCTCGGTCGTCCAGCAGCACCAGGAGGCCTTGGTC
CCCGCGCAGCCCCAGCTCAACGTGTGCAACTGGGCGGTCATGAACTGGGCACCTCCGGGC
TGTGAAAAGTTAGGGAAGTGTCTGACACCTCCAGAATCCATTCCCAAGAAGTGCCTCTGG
TCCCACTAG

Clone variation with respect to NM_000512.4
5' Read Nucleotide Sequence
>OriGene 5' read for NM_000512 unedited
CACATTTTGTAATACGACTCACTATTAGGGCGGCCGCGAATTCGCACGAGGGGCCGGAGG
GCCGGCGGACGCTCGCTAGGTCGGCTCGCTGGCCGGGGCTCCGCGGCTCCCGTGGTTGCC
ATGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAGCTGTTGCTGGTGCTCAGCGCCGCG
GGGATGGGGGCCTCGGGCGCCCCGCAGCCCCCCAACATCCTGCTCCTGCTCATGGACGAC
ATGGGATGGGGTGACCTCGGGGTGTATGGAGAGCCCTCCAGAGAGACCCCGAATTTGGAC
CGGATGGCTGCAGAAGGGCTGCTTTTCCCAAACTTCTATTCTGCCAACCCTCTGTGCTCG
CCATCGAGGGCGGCACTGCTCACAGGACGGCTACCCATCCGCAATGGCTTCTACACCACC
AACGCCCATGCCAGAAACGCCTACACACCGCAGGAGATTGTGGGCGGCATCCCAGACTCG
GAGCAGCTCCTGCCGGAGCTTCTGAAGAAGGCCGGCTACGTCAGCAAGATTGTCGGCAAG
TGGCATCTGGGTCACAGGCCCCAGTTCCACCCCCTGAAGCACGGATTTGATGAGTGGTTT
GGATCCCCCAACTGCCACTTTGGACCTTATGACAACAAGGCCAGGCCCAACATCCCTGTG
TACAGGGACTGNGAGATGGTTGGCAGATATTATGAAGAATTTCCTATTTAATCTGAGACG
GGGNAAGCCNACCTCACCCAGATCTACCCTGCAGAAGCCCTGGACTTCATTTAGAGACAG
GCACGGCACCACCCCCTTTTTCCTCTACTGGGCTGTCGACGCCACGCACGCACCCGTCTT
TGCCTCCAAACCTTCTTGGGCACAGTCANCGAGGGCGGTTTGGAAACCCCGTTCCCGGAG
ATTGATGAAGCATGNGGGAGGAACTGGGACTCCTCCAGACCTGCACCGTGCGGGCACCCC
T
3' Read Nucleotide Sequence
>OriGene 3' read for NM_000512 unedited
TCCTGCCTCCCGCTTNTATTTCTAAATAACATAGTTACAATGATAAGAAGCTACACGCCT
CCCTCATAATTANGCGTCCAGGNGAAATTCCTTGTGGACAAAGGACAGACGGAACTGGAA
GTCATCCCTCTGGGGCTCCCCTGAGACAAACGCTTATATGATTGCCCCGTTCCCTTACTG
TTTACATAAAAATGCGGATTCACTGGGCCAGACTCAATCGTGTATTCAGTGGAAGGCTGA
CTGAACCAATGTACGCCATACACATACTGATCTTGTGTCTCCCTAAGATGTATAAAGGCA
AACTGTATCCCCAGCCACCTCAGGCACCTGTTGTCAGGACCTCCTGAGGCTGTCACAGGT
GCATCCTTAACCTTGGCAAAATAAACTGAGACTGGTCTCAGATATTTGGGGTTCACAAAG
GCGTGAGACGGCAGGGTCCTGAGGTCTGAGGCGCCGTGGGCGAGGAGGAGGGTCCTGAAA
TCTGAGGCGCCGTGGGCGAGGAGGAGGGCCAAGCACACGCCAGGGTCAGGTCCTGGGCAG
GTGGAATTGTGCAGTCCCCCTGCGTCTGCAGGTGCTGTCTGTCTGGCTTGGGCAGGGTTG
GGGGAGGACCGAGGCCAGAGCCATCCTTCCTCCAGGCACTTGCAGGGCCAACCGGAGATT
CTAGGCCTGGCCTGAGTCTGCGCAGGTGCTAGTGGGACCAGAGGCACTTCTTGGGAATGG
ATCCNNTGAGTGTCAGACACTTCCCTAACTTTTCACAGCCCCGGAGGTGCCCAGTTCATG
ACCGNCCAGTTGCACACGTTTGAGCTGGGGCTGCCGCGGGACCAAAGCCTCCTGGTGCTG
CTGGACGACCGAAGTGATCCTGCTGGAGGCCTCCTGGTACTCGGCGCTGGCAAGCTGAGG
GGGAACTCTCCCCTGGTCCCGTCCAGGTGGAGATCAGGCCANTTCGGTGGCTTTAGATTG
GAGTGGACCCTGAACTTCTGCAGGCAGAATAAT
Restriction Sites NotI-NotI |
ACCN NM_000512
Insert Size 2640 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_000512.3, NP_000503.1
RefSeq Size 2390 bp
RefSeq ORF 1569 bp
Locus ID 2588
UniProt ID P34059
Cytogenetics 16q24.3
Domains Sulfatase
Protein Families Druggable Genome
Protein Pathways Glycosaminoglycan degradation, Lysosome, Metabolic pathways
Summary This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. provided by RefSeq, Jul 2008
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Documents
Resources
"NM_000512" in other vectors (7)
SKU Description Size Price
RC208708 GALNS (Myc-DDK-tagged)-Human galactosamine (N-acetyl)-6-sulfate sulfatase (GALNS) 10 ug
$289.00 $486.00
RC208708L1 Lenti ORF clone of Human galactosamine (N-acetyl)-6-sulfate sulfatase (GALNS), Myc-DDK-tagged 10 ug
$786.00
RC208708L2 Lenti ORF clone of Human galactosamine (N-acetyl)-6-sulfate sulfatase (GALNS), mGFP tagged 10 ug
$786.00
RC208708L3 Lenti ORF clone of Human galactosamine (N-acetyl)-6-sulfate sulfatase (GALNS), Myc-DDK-tagged 10 ug
$786.00
RC208708L4 Lenti ORF clone of Human galactosamine (N-acetyl)-6-sulfate sulfatase (GALNS), mGFP tagged 10 ug
$786.00
RG208708 GALNS (tGFP-tagged) - Human galactosamine (N-acetyl)-6-sulfate sulfatase (GALNS) 10 ug
$489.00 $686.00
SC322674 GALNS (untagged)-Human galactosamine (N-acetyl)-6-sulfate sulfatase (GALNS) 10 ug
$487.00

file-alt Citations

AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase
Chen, Kuo, Li et al
J Biol Chem (2008) 283 (15), 10048-57 DOI: 10.1074/jbc.M708151200
AI Summary: In this study, OriGene’s human AGPAT6 cDNA clone was used to overexpress AGPAT6 in HEK293 cells, enabling the authors to characterize its enzymatic activity and demonstrate its role as a microsomal glycerol-3-phosphate acyltransferase (GPAT).
Distinct effects of N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase expression on chondroitin sulfates
Bhattacharyya, Kotlo, Shukla et al
J Biol Chem (2008) 283 (15), 9523-30 DOI: 10.1074/jbc.M707967200
AI Summary: OriGene products, specifically the ASB (RC201307) and GALNS (RC211204) cDNA clones, were used to overexpress N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase in MCF-7 cells, enabling the study of how these enzymes regulate chondroitin sulfate content and related proteoglycans.
Showing 1-2 of 2 papers.
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