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FOLR2 (NM_000803) Human Untagged Clone

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SKU
SC119666
FOLR2 (untagged)-Human folate receptor 2 (fetal) (FOLR2), transcript variant 1
  $300.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol FOLR2
Synonyms BETA-HFR; FBP; FBP/PL-1; FOLR1; FR-BETA; FR-P3; FRbeta
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC119666 sequence for NM_000803 edited (data generated by NextGen Sequencing)
ATGGTCTGGAAATGGATGCCACTTCTGCTGCTTCTGGTCTGTGTAGCCACCATGTGCAGT
GCCCAGGACAGGACTGATCTCCTCAATGTCTGTATGGATGCCAAGCACCACAAGACAAAG
CCAGGTCCTGAGGACAAGCTGCATGACCAATGCAGTCCCTGGAAGAAGAATGCCTGCTGC
ACAGCCAGCACCAGCCAGGAGCTGCACAAGGACACCTCCCGCCTGTACAACTTTAACTGG
GACCACTGCGGCAAGATGGAGCCCGCCTGCAAGCGCCACTTCATCCAGGACACCTGTCTC
TATGAGTGCTCACCCAACCTGGGGCCCTGGATCCAGCAGGTGAATCAGAGCTGGCGCAAA
GAACGCTTCCTGGATGTGCCCTTATGCAAAGAGGACTGTCAGCGCTGGTGGGAGGATTGT
CACACCTCCCACACGTGCAAGAGCAACTGGCACAGAGGATGGGACTGGACCTCAGGAGTT
AACAAGTGCCCAGCTGGGGCTCTCTGCCGCACCTTTGAGTCCTACTTCCCCACTCCAGCT
GCCCTTTGTGAAGGCCTCTGGAGTCACTCATACAAGGTCAGCAACTACAGCCGAGGGAGC
GGCCGCTGCATCCAGATGTGGTTTGATTCAGCCCAGGGCAACCCCAACGAGGAAGTGGCG
AGGTTCTATGCTGCAGCCATGCATGTGAATGCTGGTGAGATGCTTCATGGGACTGGGGGT
CTCCTGCTCAGTCTGGCCCTGATGCTGCAACTCTGGCTCCTTGGCTGA

Clone variation with respect to NM_000803.4
5' Read Nucleotide Sequence
>OriGene 5' read for NM_000803 unedited
TTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGGTCTACCCTGTACCGAA
GACAGAGGCTGTGGGGACAGCCTAGGGGCCTGGATCTATTGCCTACTTAGAGAGAGGCCA
ACTCAGACACAGCCGTGTATGCTCCCAGCAGCAACGGAGGTTCAGCTCCGCCTGCAGGGA
CAGAAAGACATGGTCTGGAAATGGATGCCACTTCTGCTGCTTCTGGTCTGTGTAGCCACC
ATGTGCAGTGCCCAGGACAGGACTGATCTCCTCAATGTCTGTATGGATGCCAAGCACCAC
AAGACAAAGCCAGGTCCTGAGGACAAGCTGCATGACCAATGCAGTCCCTGGAAGAAGAAT
GCCTGCTGCACAGCCAGCACCAGCCAGGAGCTGCACAAGGACACCTCCCGCCTGTACAAC
TTTAACTGGGACCACTGCGGCAAGATGGAGCCCGCCTGCAAGCGCCACTTCATCCAGGAC
ACCTGTCTCTATGAGTGCTCACCCAACCTGNGGCCCTGGATCCAGCAGGTGAATCAGAGC
TGGCGCAAAGAACGCTTCCTGGATGTGCCCTTATGCAAAGAGGACTGTCAGCGCTGGTGG
GAGGATTGTCACACCTCCCACACGTGCAAGAGCAACTGGCACAGAGGATGGGACTGGACC
TCANGAGTTAACAAGTGCCCAGCTGGGGCTCTCTGCCGCACCTTTGAGTCCTACTTCCCC
ACTNCAGCTGCCCTTTGTGAAGGCCTNCTGGAGTCACTCATACANGGGTCAGCACTACAG
CCGAGGGAGCGGCCGCTGCATCCAGATTGTGGTTTGATTCAGCCAGGGCAACCCACGAGG
AAGGGGCGAGTTCTTGCTGCAGCATGCATGGATGCTGNGAGAGCTCATGGACCTGGGGTC
TCTGCTCATCTGGCCTGAG
3' Read Nucleotide Sequence
>OriGene 3' read for NM_000803 unedited
ATGAACCGCGGCACGCAATCTATAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCTTTTTATAAAAAAACAATCTGTTTATTA
AAAAGGACTTTTGGCCCCCCCATGGAACAACAACAAACTGGGGGACAAAGGGTTAGGGGA
CTAAAAAAACCATGCTTAAGGGGCTGTCTTTTGGGGGAACTGAACTGACCCCACCCTGGT
TATCCAAACTGAGGGCAGGTATTCTGGGAGGACTGAACTCACCCAAGGAGCCAAATTTGC
ACCATCAGGGCCAAACTGAACAGGAAACCCCCAGTCCCATGAAACATTTCACCAACATTC
ACATGCATGGGTGGAGAAAAAAACCCCCCCACTTCCTCGTTGGGGTTGCCCTGGGCTGAA
TCAAACCACATTTGGATGCAGGGGCCGCTCCCTCGGGTGTAATTGCTGACCTTGTATAAA
GGACCCCAAAGGCCTTCCCAAAGGGCATCTGGAGGGGGGAATTAGGACTCAAAGGGGCGG
CAAAAAGCCCCAGCTGGGCCCTTGTTAACTCCTGAGGCCCAATCCCATCCTTTGTGCCAA
TTGCTCTTGCACGTGGGGGAAGTGTGACAATCCTCCCACCAACGCTAGAAGTTCCTTTTG
CATAAGGGCACATCCAGGAAAGCGTTCTTTGCGCCACTTCTGATTCACCTGCTGGATACA
CAGCCCCAGGGTGGGGTGAGCCCTCTTAAAAAAAGGGTCCTGGAATAAATGGCCCTTGGA
AGCCGGCTCCTTTTGCCCGAGGGGCCCAAGTTAAGTTGTCAGGCGGGAGGGGGCCCTTGG
CACCCTCTGGTGGGGGCGGGGTGGCCAAAAGCATTTTTTTCCAGGGACTGGTTTGGCATG
CAACTTGTTCTCAGACCCGTCTTTTTTTTGGGGGGCTGCGCCCCATAAAACCTGGGGGAA
AAAACCCCGCCTCGGCCTGGCAAGGGGGCTCAAAAAACAAAAA
Restriction Sites NotI-NotI |
ACCN NM_000803
Insert Size 1240 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_000803.2, NP_000794.1
RefSeq Size 1119 bp
RefSeq ORF 768 bp
Locus ID 2350
UniProt ID P14207
Cytogenetics 11q13.4
Domains Folate_rec
Protein Families Druggable Genome, Secreted Protein
Summary The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. provided by RefSeq, Jul 2008
Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.
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Documents
Resources
"NM_000803" in other vectors (6)
SKU Description Size Price
RC212993 FOLR2 (Myc-DDK-tagged)-Human folate receptor 2 (fetal) (FOLR2), transcript variant 1 10 ug
$300.00
RC212993L1 Lenti ORF clone of Human folate receptor 2 (fetal) (FOLR2), transcript variant 1, Myc-DDK-tagged 10 ug
$600.00
RC212993L2 Lenti ORF clone of Human folate receptor 2 (fetal) (FOLR2), transcript variant 1, mGFP tagged 10 ug
$600.00
RC212993L3 Lenti ORF clone of Human folate receptor 2 (fetal) (FOLR2), transcript variant 1, Myc-DDK-tagged 10 ug
$600.00
RC212993L4 Lenti ORF clone of Human folate receptor 2 (fetal) (FOLR2), transcript variant 1, mGFP tagged 10 ug
$600.00
RG212993 FOLR2 (tGFP-tagged) - Human folate receptor 2 (fetal) (FOLR2), transcript variant 1 10 ug
$489.00 $500.00

file-alt Citations

Potent Therapeutic Activity Against Peritoneal Dissemination and Malignant Ascites by the Novel Anti-Folate Receptor Alpha Antibody KHK2805
Ando, Nagata, Nihira et al
Transl Oncol (2017) 10 (5), 707-718 DOI: 10.1016/j.tranon.2017.06.007
AI Summary: OriGene products contributed to this study by providing cDNAs of FOLR1 (NM_016725.2, SC122853) and FOLR2 (NM_000803.2, SC119666), which were used to produce recombinant proteins essential for evaluating the binding and specificity of the novel antibody KHK2805.
Snippet: described above. Recombinant Proteins. cDNAs of FOLR1 (NM_016725.2), FOLR2 (NM_000803.2) and FOLR3 (BC148785.1) were purchased from Origene (SC122853, SC119666) and Open Biosystems (100015838). Polyhistidine ... All 4 versions Cite SaveSaving
FigureFigureFigure
Showing 1-1 of 1 papers.
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