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LAMP2 (NM_002294) Human Untagged Clone

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SKU
SC118738
LAMP2 (untagged)-Human lysosomal-associated membrane protein 2 (LAMP2), transcript variant A
  $457.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol LAMP2
Synonyms CD107b; DND; LAMP-2; LAMPB; LGP-96; LGP110
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_002294 edited
GAATTCGGCACGAGGGGTCATCAGTGCTCTTGACCCAGGTCCAGCGAGCCTTTTCCCTGG
TGTTGCAGCTGTTGTTGTACCGCCGCCGTCGCCGCCGTCGCCGCCTGCTCTGCGGGGTCA
TGGTGTGCTTCCGCCTCTTCCCGGTTCCGGGCTCAGGGCTCGTTCTGGTCTGCCTAGTCC
TGGGAGCTGTGCGGTCTTATGCATTGGAACTTAATTTGACAGATTCAGAAAATGCCACTT
GCCTTTATGCAAAATGGCAGATGAATTTCACAGTACGCTATGAAACTACAAATAAAACTT
ATAAAACTGTAACCATTTCAGACCATGGCACTGTGACATATAATGGAAGCATTTGTGGGG
ATGATCAGAATGGTCCCAAAATAGCAGTGCAGTTCGGACCTGGCTTTTCCTGGATTGCGA
ATTTTACCAAGGCAGCATCTACTTATTCAATTGACAGCGTCTCATTTTCCTACAACACTG
GTGATAACACAACATTTCCTGATGCTGAAGATAAAGGAATTCTTACTGTTGATGAACTTT
TGGCCATCAGAATTCCATTGAATGACCTTTTTAGATGCAATAGTTTATCAACTTTGGAAA
AGAATGATGTTGTCCAACACTACTGGGATGTTCTTGTACAAGCTTTTGTCCAAAATGGCA
CAGTGAGCACAAATGAGTTCCTGTGTGATAAAGACAAAACTTCAACAGTGGCACCCACCA
TACACACCACTGTGCCATCTCCTACTACAACACCTACTCCAAAGGAAAAACCAGAAGCTG
GAACCTATTCAGTTAATAATGGCAATGATACTTGTCTGCTGGCTACCATGGGGCTGCAGC
TGAACATCACTCAGGATAAGGTTGCTTCAGTTATTAACATCAACCCCAATACAACTCACT
CCACAGGCAGCTGCCGTTCTCACACTGCTCTACTTAGACTCAATAGCAGCACCATTAAGT
ATCTAGACTTTGTCTTTGCTGTGAAAAATGAAAACCGATTTTATCTGAAGGAAGTGAACA
TCAGCATGTATTTGGTTAATGGCTCCGTTTTCAGCATTGCAAATAACAATCTCAGCTACT
GGGATGCCCCCCTGGGAAGTTCTTATATGTGCAACAAAGAGCAGACTGTTTCAGTGTCTG
GAGCATTTCAGATAAATACCTTTGATCTAAGGGTTCAGCCTTTCAATGTGACACAAGGAA
AGTATTCTACAGCTCAAGACTGCAGTGCAGATGACGACAACTTCCTTGTGCCCATAGCGG
TGGGAGCTGCCTTGGCAGGAGTACTTATTCTAGTGTTGCTGGCTTATTTTATTGGTCTCA
AGCACCATCATGCTGGATATGAGCAATTTTAGAATCTGCAACCTGATTGATTATATAAAA
ATACATGCAAATAACAAGATTTTCTTACCTCTCAGTTGTTGAAACACTTTGCTTCTTAAA
ATTGATATGTTGAAACTTTAATTCTTTTATCAATCCCAGCATTTTGAGATCAGTCTTTAT
TAATAAAACCTGTTCTCTTTAATCAGCTTAAAATCCAAAGTGTCATATTTACTGGTCCTG
GAGACAAACTTGTTCAAAAGAACATCAACGTGCAATGTTTTAAGGTCTATCTTAAGAAGC
CCTGGCCAAATTTTGATCCTAACCTTGAAGTATGCCTTGAACTTATTAACATGGCCATTA
TAAGAATAAAATATGTAGTTGTGTCTTAATGGAATTAATAAATGTCATTTCACTAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAACTCGAC
5' Read Nucleotide Sequence
>OriGene 5' read for NM_002294 unedited
GGGTCAGTATATTTGTATACGACTCACTATTAGGGCGGCCGCGAATTCGCACGAGGGGTC
ATCAGTGCTCTTGACCCAGGTCCAGCGAGCCTTTTCCCTGGTGTTGCAGCTGTTGTTGTA
CCGCCGCCGTCGCCGCCGTCGCCGCCTGCTCTGCGGGGTCATGGTGTGCTTCCGCCTCTT
CCCGGTTCCGGGCTCAGGGCTCGTTCTGGTCTGCCTAGTCCTGGGAGCTGTGCGGTCTTA
TGCATTGGAACTTAATTTGACAGATTCAGAAAATGCCACTTGCCTTTATGCAAAATGGCA
GATGAATTTCACAGTACGCTATGAAACTACAAATAAAACTTATAAAACTGTAACCATTTC
AGACCATGGCACTGTGACATATAATGGAAGCATTTGTGGGGATGATCAGAATGGTCCCAA
AATAGCAGTGCAGTTCGGACCTGGCTTTTCCTGGATTGCGAATTTTACCAAGGCAGCATC
TACTTATTCAATTGACAGCGTCTCATTTTCCTACAACACTGGTGATAACACAACATTTCC
TGATGCTGAAGATAAAGGAATTCTTACTGTTGATGAACTTTTGGCCATCAGAATTCCATT
GAATGACCTTTTTAGATGCAATAGTTTATCAACTTTGGAAAAGAATGATGTTGTCCAACA
CTACTGGGATGTTCTTGTACAAGCTTTTGTCCAAAATGGCACAGTGACCCAANATGAGTT
TCCTGTGTGATAAAGACCAAACTTCAACAGTGGCACCCACCATACACACCACTGTTGCCA
TCTCCTACTACAACACCTACTCCAAAGAAAAACCAGAAGCTGGCACCTATTCAGTTAATA
ATGGCAATGATCCTTGTCTGCTGGCTACCATGGCGCTGCAGCTGAACATCACTCACGATA
AGTTGCTCCAATTATTACCT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_002294 unedited
AAAAAGCTGAGGTTTNTTTACNTNCTTTAAGGACCAACTACATATCTTTATTCTTATAAT
GGCCATGTTAATAAGTTCAAGGCATACTTCAAGGTTAGGATCAAAATTTGGCCAGGGCTT
CTTAAGATAGACCTTAAAACATTGCACGTTGATGTTCTTTTGAACAAGTTTGTCTCCAGG
ACCAGTAAATATGACACTTTGGATTTTAAGCTGATTAAAGATAACAGGTTTTATTAATAA
AGACTGATCTCAAAATGCTGGGATTGATAAAAGAATTAAAGTTTCAACATATCAATTTTA
AGAAGCAAAGTGTTTCAACAACTGAGAGGTAAGAAAATCTTGTTATTTGCATGTATTTTT
ATATAATCAATCAGGTTGCAGATTCTAAAATTGCTCATATCCAGCATGATGGTGCTTGAG
ACCAATAAAATAAGCCAGCAACACTAGAATAAGTACTCCTGCCAAGGCAGCTCCCACCGC
TATGGGCACAAGGAAGTTGTCGTCATCTGCACTGCAGTCTTGAGCTGTAGAATACTTTCC
TTGTGTCACATTGAAAGGCTGAACCCTTAGATCAAAGGTATTTATCTGAAATGCTCCAGA
CACTGAAACAGTCTGCTCTTTGTTGCACATATAAGAACTTCCCAGGGGGGCATCCCAGTA
GCTGAGATTGTTATTTGCAATGGCTGAAACGGAGCCATTAACCAAATACATGCTGATGTT
CACTTCCTTCAGATAAAATCGGTTTTCATTTTTCACAGCAAAGACCAAGTCTAGATACTT
AATGGTGCTGCTATTGAGTCTAAGTAGAGCAGTGTGAGAACCGCAGCTGCCTGTGGAGTG
AGTTGTATTGGGGCTGATGTTAATACTGAAGCAACCTATTCTGAGTGA
Restriction Sites NotI-NotI |
ACCN NM_002294
Insert Size 1233 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_002294.1, NP_002285.1
RefSeq Size 1868 bp
RefSeq ORF 1233 bp
Locus ID 3920
UniProt ID P13473
Cytogenetics Xq24
Domains Lamp
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Lysosome
Summary The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. provided by RefSeq, Jul 2008
Transcript Variant: This variant (A) is the longest and predominant form of this gene. Variant A encodes isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.
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Documents
Resources
"NM_002294" in other vectors (6)
SKU Description Size Price
RC221216 LAMP2 (Myc-DDK-tagged)-Human lysosomal-associated membrane protein 2 (LAMP2), transcript variant A 10 ug
$457.00
RC221216L1 Lenti ORF clone of Human lysosomal-associated membrane protein 2 (LAMP2), transcript variant A, Myc-DDK-tagged 10 ug
$757.00
RC221216L2 Lenti ORF clone of Human lysosomal-associated membrane protein 2 (LAMP2), transcript variant A, mGFP tagged 10 ug
$757.00
RC221216L3 Lenti ORF clone of Human lysosomal-associated membrane protein 2 (LAMP2), transcript variant A, Myc-DDK-tagged 10 ug
$757.00
RC221216L4 Lenti ORF clone of Human lysosomal-associated membrane protein 2 (LAMP2), transcript variant A, mGFP tagged 10 ug
$757.00
RG221216 LAMP2 (tGFP-tagged) - Human lysosomal-associated membrane protein 2 (LAMP2), transcript variant A 10 ug
$489.00 $657.00

file-alt Citations

Chaperone-mediated autophagy regulates the metastatic state of mesenchymal tumors
Zhou, Berenger, Shi et al
EMBO Mol Med (2025) 17 (4), 747-774 DOI: 10.1038/s44321-025-00210-w
Cited by 7
AI Summary: OriGene’s pCMV6-XL5-LAMP2 (Cat# SC118738) plasmid was used in this study to investigate the role of LAMP-2A in chaperone-mediated autophagy and its impact on the metastatic behavior of mesenchymal tumors.
Snippet: pCMV6-XL5-LAMP2 Origene SC118738 pSIN-PAmCherry-KFERQ-NE Addgene 102365
Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology
Navarro-Romero, Fernandez-Gonzalez, Riera et al
NPJ Parkinsons Dis (2022) 8 (1), 126 DOI: 10.1038/s41531-022-00397-6
Cited by 97
AI Summary: In this study, the OriGene human LAMP-2 cDNA plasmid (SC118738) was used to transiently overexpress LAMP-2 in dopaminergic cell lines to investigate the effects of lysosomal dysfunction and chaperone-mediated autophagy deficiency in models of glucocerebrosidase deficiency.
Snippet: Amplex Red Cholesterol Assay Kit (A12216;Thermo Fisher Scientific) according to the manufacturer’s instructions. Transfection Plasmid expressing human LAMP-2 cDNA (transcript variant A;SC118738;OriGene, Rockville, MD, USA) was transiently transfected into BE(2)-M17 cell lines using Lipofectamine 3000 Reagent (L3000015;Thermo Fisher Scientific) according to the manufacturer’s protocol. St
FigureFigureFigure
Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models
Su, Yang, Lou
Brain Res. (2016)
Cited by 74
AI Summary: OriGene contributed to this study by providing the LAMP2A expression plasmid (catalog no.: SC118738), which was used to overexpress LAMP2A in SH-SY5Y cells and investigate its role in regulating α-synuclein levels in Parkinson’s disease models.
Snippet: LAMP2A was overexpressed in SHSY5Y cells using a LAMP2A expression plasmid harboring a full-length open-reading frame and driven by the cytomegalovirus promoter, which was obtained from OriGene (catalog no.: SC118738;OriGene Technologies, Inc, Rockville ... Cite SaveSaving
Chaperone-mediated autophagy regulates proliferation by targeting RND3 in gastric cancer
Zhou, Yang, Fan et al
Autophagy (2016)
Cited by 108
AI Summary: OriGene’s LAMP2A, LAMP2B, and LAMP2C plasmids (SC118738, SC127527, SC318864) and control plasmids (PCMV6XL5, PCMV6XL6) were used for transfection experiments to investigate the role of chaperone-mediated autophagy in gastric cancer cell proliferation.
Snippet: RND3 plasmid and control plasmid were transfected into cells as described previously.47 LAMP2A, LAMP2B and LAMP2C plasmids (OriGene, SC118738, SC127527 and SC318864) and their control plasmids (OriGene, PCMV6XL5 and PCMV6XL6) were used. The lentiviral vectors with shRNAs against LAMP2A were purchased from GeneChem Company, Shanghai, China (PIEL248064052). …
LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy
Saha
Autophagy (2012) 8 (11), 1643-56 DOI: 10.4161/auto.21654
Cited by 159
AI Summary: OriGene’s LAMP2A expression plasmid (catalog number SC118738) was used in this study to ectopically overexpress LAMP2A in breast cancer cells, enabling the investigation of its role in promoting cancer cell survival via chaperone-mediated autophagy.
Snippet: established in a Myc-induced lymphoma model in which inhibition of autophagy with either chloroquine or ATG5 short hairpin RNA ... LAMP2A expression plasmid was purchased from ORIGENE, (SC118738) that harbors a full length open reading frame (ORF) and driven by the
Showing 1-5 of 5 papers.
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