SorLA (SORL1) (NM_003105) Human Untagged Clone
SKU
SC118159
SORL1 (untagged)-Human sortilin-related receptor, L(DLR class) A repeats containing (SORL1)
$2,742.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | SorLA |
| Synonyms | C11orf32; gp250; LR11; LRP9; SORLA; SorLA-1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_003105 |
| Insert Size | 6900 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_003105.3, NP_003096.1 |
| RefSeq Size | 6906 bp |
| RefSeq ORF | 6645 bp |
| Locus ID | 6653 |
| UniProt ID | Q92673 |
| Cytogenetics | 11q24.1 |
| Domains | BNR, FN3, ldl_recept_a, ldl_recept_b, VPS10 |
| Protein Families | Druggable Genome, Transmembrane |
| Summary | This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. provided by RefSeq, Feb 2016 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_003105" in other vectors (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC214154 | SORL1 (Myc-DDK-tagged)-Human sortilin-related receptor, L(DLR class) A repeats containing (SORL1) | 10 ug |
$2,740.00
|
|
| RC214154L1 | Lenti ORF clone of Human sortilin-related receptor, L(DLR class) A repeats containing (SORL1), Myc-DDK-tagged | 10 ug |
$3,040.00
|
|
| RG214154 | SORL1 (tGFP-tagged) - Human sortilin-related receptor, L(DLR class) A repeats containing (SORL1) | 10 ug |
$2,940.00
|
|
Citations
ApoE-isoform-dependent cellular uptake of amyloid-β is mediated by lipoprotein receptor LR11/SorLA
Yajima, Tokutake, Koyama et al
Biochem. Biophys. Res. Commun. (2015) 456 (1), 482-8 DOI: 10.1016/j.bbrc.2014.11.111
Yajima, Tokutake, Koyama et al
Biochem. Biophys. Res. Commun. (2015) 456 (1), 482-8 DOI: 10.1016/j.bbrc.2014.11.111
Cited by 44
AI Summary: OriGene's pCMV6 plasmid cDNA containing human LR11 was used as the template to amplify full-length LR11, enabling the study of LR11/SorLA's role in apoE-isoform-dependent cellular uptake of amyloid-β.
Snippet: Complementary DNA (cDNA) of human full-length LR11 was amplified by PCR using pCMV6 plasmid cDNA containing human LR11 (Origene, Rockville, USA) and cloned into the pcDNA3.1 vector (Life Technologies, Carlsbad, USA). ... Cite SaveSaving
Showing 1-1 of 1 papers.
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in shipping.
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