STAM2 (NM_005843) Human Untagged Clone

SKU SC116490

STAM2 (untagged)-Human signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 (STAM2)

Product Data

• Type: Human Untagged Clone
• Target Symbol: STAM2
• Synonyms: Hbp; STAM2A; STAM2B
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC116490 sequence for NM_005843 edited (data generated by NextGen Sequencing); ATGCCTTTGTTCACCGCCAACCCCTTCGAGCAAGACGTGGAAAAAGCCACGAATGAGTAC; AACACTACAGAAGATTGGAGTCTTATTATGGACATATGTGACAAAGTTGGAAGTACTCCT; AATGGAGCGAAAGATTGCCTAAAAGCCATAATGAAAAGGGTAAATCATAAGGTTCCACAT; GTTGCTCTGCAAGCACTAACTCTTCTTGGGGCTTGTGTGGCAAACTGTGGAAAGATATTT; CATTTAGAAGTATGTTCCCGTGATTTTGCAACAGAAGTACGTGCTGTGATTAAAAATAAG; GCACATCCTAAAGTATGTGAAAAACTGAAATCTTTAATGGTGGAGTGGTCAGAAGAATTT; CAGAAGGACCCTCAGTTTAGTCTGATATCTGCAACTATTAAATCTATGAAAGAAGAAGGA; ATTACTTTTCCTCCAGCAGGTTCTCAGACTGTCTCAGCTGCTGCCAAGAATGGTACGTCA; TCGAACAAAAACAAAGAGGATGAAGACATAGCTAAAGCTATTGAATTATCGCTGCAAGAA; CAGAAACAGCAACACACAGAAACAAAATCCTTATATCCATCTTCAGAAATTCAGTTAAAT; AATAAGGTTGCACGGAAAGTGAGAGCTTTATATGATTTTGAAGCTGTTGAGGACAATGAA; CTCACCTTTAAACATGGTGAAATAATTATTGTTTTGGATGACAGTGATGCCAATTGGTGG; AAAGGAGAAAATCACAGAGGAATAGGACTTTTCCCATCCAATTTTGTAACAACTAATTTA; AACATAGAGACTGAGGCAGCGGCTGTGGACAAATTGAATGTAATTGATGATGATGTGGAG; GAAATTAAGAAATCAGAGCCTGAGCCTGTTTATATAGATGAGGATAAGATGGATAGAGCC; CTGCAGGTACTTCAGAGTATAGATCCAACAGATTCAAAACCAGACTCCCAAGACCTTTTG; GATTTAGAAGATATCTGCCAACAGATGGGTCCAATGATAGATGAAAAACTTGAAGAAATT; GATAGGAAGCATTCAGAATTGTCTGAATTGAATGTTAAAGTCCTGGAAGCTCTGGAACTA; TATAACAAATTGGTGAATGAAGCACCAGTGTACTCAGTCTATTCAAAGCTCCACCCTCCA; GCACATTACCCACCTGCATCATCTGGGGTTCCAATGCAGACATATCCAGTTCAATCACAT; GGTGGAAACTATATGGGTCAGAGCATTCACCAAGTAACTGTTGCCCAAAGCTATAGCCTA; GGACCCGATCAAATTGGTCCACTGAGATCTCTGCCTCCAAATGTGAATTCCTCAGTGACA; GCACAGCCTGCTCAAACTTCATATTTAAGCACTGGACAAGACACTGTTTCCAATCCTACT; TATATGAACCAGAACTCTAACCTACAGTCAGCTACTGGTACAACTGCTTACACACAGCAA; ATGGGGATGTCTGTGGATATGTCATCTTATCAGAACACTACTTCCAATTTGCCTCAACTG; GCAGGCTTTCCGGTGACAGTTCCAGCTCATCCAGTTGCACAGCAGCACACAAATTACCAT; CAGCAGCCTCTCCTTTAG; ; Clone variation with respect to NM_005843.4;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005843 unedited; NGGTTCGGATTTTGTAATACGATCTCACTATAGGGCGGCCGCGAATTCGCACGAGCCGAA; GCGGAGCGGTCTAGGGAGCCGCGGCCGCGGGTCACCCGGCGGGTAGCAGTTGCTGAGTGT; CAGCTAGACAGCAGCGACTAGGGCTCGGGCGCCGGCGAGATGCCTTTGTTCACCGCCAAC; CCCTTCGAGCAAGACGTGNGAAAAAGCCACGAATGAGTACAACACTACAGAAGATTGGAG; TCTTATTATGGACATATGTGACAAAGTTGGAAGTACTCCTAATGGAGCGAAAGATTGCCT; AAAAGCCATAATGAAAAGGGTAAATCATAAGGTTCCACATGTTGCTCTGCAAGCACTAAC; TCTTCTTGGGGCTTGTGTGGCAAACTGTGGAAAGATATTTCATTTAGAAGTATGTTCCCG; TGATTTTGCAACAGAAGTACGTGCTGTGATTAAAAATAAGGCACATCCTAAAGTATGTGA; AAAACTGAAATCTTTAATGGTGGAGTGGTCAGAAGAATTTCAGAAGGACCCTCAGTTTAG; TCTGATATCTGCAACTATTAAATCTATGAAAGAAGAAGGAATTACTTTTCCTCCAGCAGG; TTCTCAGACTGTCTCAGCTGCTGCCAAGAATGGTACGTCATCGAACAAAAACAAAGAGGA; TGAAGACATAGCTAAAGCTATTGAATTATCGCTGNCAGAACAGAAACAGCAACACACAGA; AACAAAATCCTTATATCCATCTTCAGAAATTCAGTTAAATAATAAGGGTGCACGGNAAGT; GAGAGCTTNTATGATTTTTGAGCTGNNTGAGACAATGAACTCACCTTTAAACATGGTGAA; AATATTATGNTTTGGATGACAGTGATGCCAATTGGTGGNAAGNAGNAAATCACNGAGGAT; AGGACTTTTCCCATCCATTTTGTACA;
• Restriction Sites: NotI-NotI
• ACCN: NM_005843
• Insert Size: 2000 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_005843.3, NP_005834.3
• RefSeq Size: 3928 bp
• RefSeq ORF: 1578 bp
• Locus ID: 10254
• UniProt ID: O75886
• Cytogenetics: 2q23.3
• Domains: SH3, UIM, VHS
• Protein Pathways: Endocytosis, Jak-STAT signaling pathway
• Summary: The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]