SHOC2 (NM_007373) Human Untagged Clone

SKU SC115569

SHOC2 (untagged)-Human soc-2 suppressor of clear homolog (C. elegans) (SHOC2)

Product Data

• Type: Human Untagged Clone
• Target Symbol: SHOC2
• Synonyms: NSLH1; SIAA0862; SOC2; SUR8
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115569 sequence for NM_007373 edited (data generated by NextGen Sequencing); ATGAGTAGTAGTTTAGGAAAAGAAAAAGACTCTAAAGAAAAAGATCCCAAAGTACCATCA; GCCAAGGAAAGAGAAAAGGAGGCAAAAGCCTCTGGAGGTTTTGGGAAAGAGAGCAAAGAA; AAAGAACCTAAGACCAAAGGGAAAGATGCCAAAGATGGAAAGAAGGACTCCAGTGCTGCC; CAACCAGGGGTGGCATTTTCAGTTGACAATACGATCAAACGGCCAAACCCAGCACCTGGG; ACTAGAAAAAAATCCAGCAATGCAGAGGTGATTAAAGAGCTCAACAAATGCCGGGAAGAG; AATTCAATGCGTTTGGACTTATCCAAGAGATCTATACACATATTGCCATCATCAATCAAA; GAGTTGACTCAATTAACAGAACTTTATTTATACAGTAACAAATTGCAGTCCCTCCCAGCA; GAGGTGGGATGTTTAGTAAATCTCATGACACTGGCTCTAAGTGAAAATTCACTTACCAGT; TTGCCTGACTCTCTTGATAACTTGAAGAAGCTGCGGATGCTTGATTTACGGCATAATATA; CTGAGAGAAATTCCTTCAGTGGTGTATAGGCTGGATTCTCTCACCACTCTTTACCTTCGC; TTTAATCGTATAACTACTGTGGAAAAGGACATCAAAAACTTGTCAAAACTCAGCATGCTT; AGCATTCGAGAGAACAAAATTAAACAACTACCTGCTGAAATTGGTGAATTATGTAACCTC; ATTACGCTGGATGTAGCTCACAATCAACTTGAACACCTTCCAAAGGAGATTGGAAACTGT; ACACAGATAACCAACCTTGACTTGCAGCACAATGAACTGCTAGACCTCCCAGATACTATA; GGAAACCTGTCCAGTTTAAGTCGTCTTGGTCTGAGATATAACAGACTGTCAGCAATACCC; AGATCATTAGCAAAATGCAGTGCACTTGAAGAATTAAATTTAGAGAACAATAACATTTCT; ACTTTACCAGAGAGTCTTTTATCAAGTCTTGTGAAACTGAATAGTTTGACCTTAGCTAGA; AATTGCTTCCAGTTGTATCCAGTGGGTGGTCCATCTCAGTTTTCTACCATCTATTCCCTC; AACATGGAACACAATCGAATCAACAAAATTCCATTTGGAATTTTCTCCAGAGCAAAAGTA; TTAAGTAAGCTGAATATGAAGGACAATCAGTTAACATCACTTCCCTTGGATTTTGGAACT; TGGACCAGTATGGTAGAATTGAATTTAGCCACTAATCAGCTCACAAAGATCCCTGAGGAT; GTGTCTGGTCTCGTTTCTCTTGAGGTTCTTATCTTATCAAACAATCTTCTAAAGAAGCTT; CCCCATGGTCTTGGAAACCTTAGGAAGTTAAGAGAGTTGGATCTAGAAGAGAACAAATTG; GAATCCTTGCCAAATGAAATTGCATATCTTAAGGATTTACAGAAATTAGTCTTGACAAAC; AACCAGTTGACCACTCTTCCCAGAGGCATTGGTCACCTTACTAATCTCACACATCTGGGC; CTTGGAGAGAACCTACTTACTCACCTTCCTGAAGAAATTGGTACACTGGAGAACCTAGAA; GAACTGTATTTGAATGACAACCCCAACCTGCATAGCCTTCCCTTTGAGCTGGCACTCTGC; AGCAAGCTTTCAATCATGAGTATTGAGAACTGTCCACTCAGTCACCTTCCACCTCAGATT; GTTGCTGGGGGGCCTTCTTTCATCATTCAGTTCTTAAAGATGCAGGGTCCATATCGTGCC; ATGGTCTGA; ; Clone variation with respect to NM_007373.3; 539 a=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_007373 unedited; AGTCAAATTTGTAAACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGCTCCTGACGG; AACTCTAATGAATCATTGATTGACCAGCACTATTTTACCAGTTGGAATGAATGATCAGAA; ATGGGCATAGTGCTTTTAGATCCAACATGTAACAGATGGATGTTACTCCATGCTGATTAC; TTCTTCAAGCCAGTACTTTTTTGATTGTGTAGGATCTTTGTCTCTTCATCTTTGAATTCA; ATTACTGGAAAATAAAAGGAGTTCATGTAGTTTTTGTCCAGGCTTGAGTCACCATGAGTA; GTAGTTTAGGAAAAGAAAAAGACTCTAAAGAAAAAGATCCCAAAGTACCATCAGCCAAGG; AAAGAGAAAAGGAGGCAAAAGCCTCTGGAGGTTTTGGGAAAGAGAGCAAAGAAAAAGAAC; CTAAGACCAAAGGGAAAGATGCCAAAGATGGAAAGAAGGACTCCAGTGCTGCCCAACCAG; GGGTGGCATTTTCAGTTGACAATACGATCAAACGGCCAAACCCAGCACCTGGGACTAGAA; AAAAATCCAGCAATGCAGAGGTGATTAAAGAGCTCAACANATGCCCGGAAGAAGATTCAA; TGCGTTTGGACTTATCCAAGAGATCTATACACATATTGCCATCATCAATCANAGAGTTTG; ACTCATTAACAGAACTTTATTTATACAGTAACANATTGCAGTCCCCTCCAGCAGAAGTGG; GGATGTTTAGTAAATCTCATGACACTGGCTCTAAGTGAAAATTCACTACCAGTTTGCCTG; ACTCTCTTGATACTTGAAGAGCTGCGGATGCTTGATTTACNGCATATATACTGAAAGAAA; TTCCTCAATGGTGTATAGGCTGGATTCTCTCACCATCTTAACCTCGCCTTAATCCTATAC; TACTGGGGGAAAGGACATCAAAACTTT;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_007373 unedited; GAACCGCGCCCGCATTCTANAGTCGAGTTTTTTTTTTTTTTTTTTAGAGCTGTAATAAAC; AAATTCCTTTTATAAACAAAATTTTAACTGAAAAGCCACAGCAGATGGGGGNGAAAAAAA; AAAGAAAGGATATTACTTGGTAAAATCCAGTGACATCTACAATAGTTTTACAGCACATTT; AAGCATTCTAGGGTTTTATATCTTCACCTGCCTTCCATTTCTTAGTTGATCCTTATAAAA; TCTCTCATTACGAACATAGGTTTGACCTCAAAACTAGTCATGAATTTGAGTGCCAGGAAA; AGCAGAACAACAGTCCAAATTTCTATCTTAATATCTTAGCCTTAATTCAAAAATGGTTTT; GTGTAAAACACAACGCCCAACTAAATGGAAAAAAAAAAAAACACACAAGCAGCAATATGT; AATTATACAAAATAGCGATTAATTATATATGAAGTGTTTTTTAGGATGACATCTAGAACG; CACCTTGCTCTGAGACTCCTCAATAATCAAATTGACTTAGACCAACAATACTGCTAAGTA; TTAAAAGCAGTGAAGCAAAGAAAACGCATCAAATAGTACATGCACATTTTACAGAACTTC; CACTGAACTCCCCAATGGCTTCTATGCAATGTGCCTCTTTTCCATAACTGTTTTAACACC; CCCCAAGAAAGGAAATATGAGATTAAAAGGAATGATCCTGAACCGAATTGTTAGAACCCA; GTGCCCCATATGTGGGGGACAAGCGCATTTATTTTAAACTCCATTCAGCCCAGTGGCGAA; AATCTTGCGCCTCAACCCAGAATTTCCCAAATTGAAAAAATGTCCATGGCAGTCACAATA; TACAACCCTTCCACCCCCGTTCAAAAACCTTGGACCATACTCCCTTTCCTATTTCAAAAA; ACGCACTTT;
• Restriction Sites: NotI-NotI
• ACCN: NM_007373
• Insert Size: 4200 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_007373.2, NP_031399.2
• RefSeq Size: 3823 bp
• RefSeq ORF: 1749 bp
• Locus ID: 8036
• UniProt ID: Q9UQ13
• Cytogenetics: 10q25.2
• Domains: LRR, LRR_BAC, LRR_TYP
• Protein Families: Druggable Genome
• Summary: This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]; Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).