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SHC3 (NM_016848) Human Untagged Clone

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SKU
SC114141
SHC3 (untagged)-Human SHC (Src homology 2 domain containing) transforming protein 3 (SHC3)
  $554.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol SHC3
Synonyms N-Shc; NSHC; RAI; SHCC
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC114141 sequence for NM_016848 edited (data generated by NextGen Sequencing)
ATGCTTCCACGCACCAAGTATAACCGCTTCAGGAATGACTCGGTGACATCGGTCGATGAC
CTTCTCCACAGCCTGTCGGTGAGCGGCGGCGGAGGCAAGGTTTCGGCGGCGCGCGCGACC
CCGGCGGCGGCTCCCTACTTGGTGTCCGGCGAGGCGCTGCGCAAGGCGCCCGACGATGGG
CCCGGCAGCCTGGGCCACCTGCTCCACAAGGTGTCCCACCTGAAACTCTCCAGCTCGGGC
CTCCGCGGCCTGTCGTCGGCCGCCCGGGAGCGGGCGGGCGCGCGGCTCTCGGGCAGCTGC
AGCGCGCCCAGCCTGGCCGCCCCGGACGGCAGTGCGCCCTCGGCGCCCCGCGCCCCGGCC
ATGAGCGCCGCCAGGAAGGGCCGGCCCGGCGACGAGCCGCTGCCCAGGCCCCCTCGGGGG
GCGCCGCACGCCAGCGACCAGGTGCTGGGGCCCGGAGTCACCTACGTGGTCAAGTACTTG
GGGTGCATTGAAGTTCTGCGCTCAATGAGGTCTCTTGACTTCAGTACAAGAACACAAATT
ACCAGGGAAGCCATCAGCCGCGTCTGTGAAGCTGTGCCTGGTGCGAAGGGAGCCTTCAAG
AAGAGAAAGCCTCCAAGCAAAATGCTGTCCAGCATCTTGGGAAAGAGCAACCTCCAGTTT
GCGGGAATGAGCATCTCTCTGACCATCTCCACGGCCAGTCTGAACCTGCGAACTCCGGAC
TCCAAACAGATCATAGCGAATCACCACATGCGGTCCATCTCCTTCGCCTCTGGGGGAGAC
CCGGACACAACTGACTATGTTGCATATGTGGCTAAGGACCCTGTTAATCGCAGAGCTTGT
CACATTTTGGAATGCTGTGATGGGCTGGCCCAGGATGTCATCGGCTCCATCGGACAAGCC
TTTGAGCTCCGGTTTAAGCAATATTTACAGTGTCCTACCAAGATTCCCGCTCTCCATGAT
CGAATGCAGAGTCTGGATGAGCCATGGACGGAAGAGGAGGGAGATGGCTCAGACCACCCA
TACTACAACAGCATCCCAAGCAAGATGCCTCCTCCAGGGGGCTTTCTTGATACTAGACTG
AAACCCAGACCCCATGCTCCTGACACAGCCCAGTTTGCAGGAAAAGAGCAGACTTATTAC
CAGGGAAGACACTTAGGAGACACTTTTGGCGAAGACTGGCAGCAAACACCTTTAAGGCAA
GGGTCCTCGGACATCTACAGCACGCCAGAAGGGAAACTGCACGTGGCCCCCACGGGAGAA
GCACCCACCTACGTCAACACTCAGCAGATCCCACCACAGGCCTGGCCGGCTGCGGTCAGC
AGTGCTGAGAGCAGCCCGAGGAAAGACCTCTTTGACATGAAACCTTTTGAAGATGCTCTC
AAGAACCAGCCCTTGGGGCCCGTGTTAAGCAAGGCAGCCTCCGTGGAGTGCATCAGCCCT
GTGTCACCTAGAGCCCCAGATGCCAAGATGCTGGAGGAACTGCAAGCCGAGACTTGGTAC
CAAGGAGAGATGAGCAGGAAGGAGGCAGAGGGGCTGCTGGAGAAAGACGGAGACTTCCTG
GTCAGGAAGAGCACCACCAACCCGGGCTCCTTTGTCCTCACGGGCATGCACAATGGCCAG
GCCAAGCACCTGCTGCTCGTGGACCCAGAAGGCACGATCCGGACAAAGGACAGAGTCTTT
GACAGTATCAGCCACCTCATCAACCACCACCTAGAAAGCAGCCTGCCCATTGTCTCTGCA
GGGAGTGAGCTGTGTCTCCAGCAGCCAGTGGAGAGGAAGCAGTGA

Clone variation with respect to NM_016848.5
1338 a=>g
5' Read Nucleotide Sequence
>OriGene 5' read for NM_016848 unedited
NGGGTCAAAATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCTCAGAG
TGAGTCATGCTTTTGCTGTGAGCAGCCCCAAGCAGCTGGGCGCTCCATCAGAGGCAACTA
TGACTTTTGCAAAGCAAACGTGCAACCCCAAGCAGCGGTCTCCCGGGCCGGGGCTGCGCG
GCCGCCGCTGTGCTGGCTTTTAACGGTGGGAGGGCACCATCCTCTTGCTCTGCTCTCGTT
CTCCAGAAGGCTGTCCCGGGGCCCCCACTCTCCGTCCCGCTCCGGGGACAGTGGCTCGCC
TGCTATGCGCGGCAGCCCGCGCCGGGGCCGGCACCAGCAGCGCCCGGGCGGATGCAGCGA
GCCCACGGAGGGGCATGCTTCCACGCACCAAGTATAACCGCTTCAGGAATGACTCGGTGA
CATCGGTCGATGACCTTCTCCACAGCCTGTCGGTGAGCGGCGGCGGAGGCAAGGTTTCGG
CGGCGCGCGCGACCCCGGCGGCGGCTCCCTACTTGGTGTCCGGCGAGGCGCTGCGCAAGG
CGCCCGACGATGGGCCCGGCAGCCTGGGCCACCTGCTCCACAAGGTGTCCCACCTGAAAC
TCTCCAGCTCGGGCCTCCGCGGCCTGTCGTCGGCCGCCCGGAGCNNGGCCCGGGCGCGCG
GATTCTCGGGCAGCTGCAGCGCGCCCAGCCTGGCCGCCCCGGACGGCAGTGCGCCCTCGG
CGCCCCGCGCCCCGGCCATGAGCGCCGNCAGGAAAGGGCCGGCCCGGCGACGAGCCGCTG
CCCAGCCCCCTTCGGGGGGCGCCGCACGCCACGACCAGGTGCTGGGCCCCCGGAGCACCT
ACGTGGGTCAGTCTTTGGGTGCATATGGAAGTTCTGCGCTCAATGAGGTCTCCTGACTTC
AGA
3' Read Nucleotide Sequence
>OriGene 3' read for NM_016848 unedited
TGTCTCTGGGAACGCGGCACGCATTCTAGGATCGAGTTTTTTTTTTTTTTTTTTCATTAA
AAACACACAGCACAGACATTAGTCTTACATCTTTCTTAGTCTTAAAAAATATAAATATAG
AGGGATAATTTGTACAGGATGTATAGGTATGTACACCTTTAATATGCATATGAGAAATTC
AGAACCAAGTTTATGAAACTTGACCTTAAAGGAAGCCTTCCTTTTGAAGCTTTTGAAGAA
GGCTCTGAGCCACAGGCAGCTGTCCCAGTTCCAGCAGCCCCGATTCTAGTCCACTCCAGG
TCCTCCTGACCTGGTGCGCAGTGCTGGGAGCAGTGCTGGCCAGGTCACTGCTTCCTCTCC
ACTGGCTGCTGGAGACACAGCTCACTCCCTGCAGAGACAATGGGCAGGCTGCTTTCTAGG
TGGTGGTTGATGAGGTGGCTGATACTGTCAAAGACTCTGTCCTTTGTCCGGATCGTGCCT
TCTGGGTCCACGAGCAGCAGGTGCTTGGCCTGGCCATTGTGCATGCCCGTGAGGACAAAG
GAGCCCGGGTTGGNTGGTGCTCTTCCTGACCAGGAAGTCTCCGTCTTTCTCCAGCAGCCC
CTCTGCCTCCTTCCTGCTCATCTCTCCTTGGTACCAAGTCTCGCCTTGCAGTTCCTCCAG
CATCTTGGCATCTGGGGCTCTAGGTGACACAGGGCTGATGCACTCCACGGAGGCTGCCTT
GCTTACACGGGCCCCAAGGGCTGGTTCTTGAGAGCATCTTCAAAAGGTTTCATGTCAAAG
AGGTCTTTTCCTCGGGCTGGTCTCAACACTGCTGACCGNANCCGGCCCAGCCTGTGGGGG
GGGATCTGCTGAGGTGTGACGTAAGGGGGTGCTTTCCCCCGGGGGGCCACGGGCAGTTTC
CTTTTGGCGTGCTGAAAAGTCCGAGGACCTTGCCTTAAAAGGGTTGCTGCAATTTTCCCC
AAGAGGTTTCTAGGGA
Restriction Sites NotI-NotI |
ACCN NM_016848
Insert Size 2240 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_016848.2, NP_058544.2
RefSeq Size 2400 bp
RefSeq ORF 1785 bp
Locus ID 53358
UniProt ID Q92529
Cytogenetics 9q22.1
Domains PID, SH2
Protein Pathways Chemokine signaling pathway, Chronic myeloid leukemia, ErbB signaling pathway, Focal adhesion, Glioma, Insulin signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway
Summary Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_016848" in other vectors (6)
SKU Description Size Price
RC205195 SHC3 (Myc-DDK-tagged)-Human SHC (Src homology 2 domain containing) transforming protein 3 (SHC3) 10 ug
$289.00 $553.00
RC205195L1 Lenti-ORF clone of SHC3 (Myc-DDK-tagged)-Human SHC (Src homology 2 domain containing) transforming protein 3 (SHC3) 10 ug
$853.00
RC205195L2 Lenti-ORF clone of SHC3 (mGFP-tagged)-Human SHC (Src homology 2 domain containing) transforming protein 3 (SHC3) 10 ug
$853.00
RC205195L3 Lenti-ORF clone of SHC3 (Myc-DDK-tagged)-Human SHC (Src homology 2 domain containing) transforming protein 3 (SHC3) 10 ug
$853.00
RC205195L4 Lenti-ORF clone of SHC3 (mGFP-tagged)-Human SHC (Src homology 2 domain containing) transforming protein 3 (SHC3) 10 ug
$853.00
RG205195 SHC3 (tGFP-tagged) - Human SHC (Src homology 2 domain containing) transforming protein 3 (SHC3) 10 ug
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file-alt Citations

Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents
Canu, Pagano, La Rosa et al
Front Mol Neurosci (2017) 10, 15 DOI: 10.3389/fnmol.2017.00015
AI Summary: OriGene contributed the ShcC plasmid (SC114141), which was used to investigate the regulation of APP and TrkA association in this study.
Snippet: Mint-2 plasmid was gently provided by Dr. Thomas C. Südhof. Plasmid for ShcC was from Origene (SC114141). DsRed-Rab-5 and DsRed-Rab11 plasmids were gently provided by Dr. Pagano (Addgene plasmids #13050, #12679 respectively)
FigureFigureFigure
Showing 1-1 of 1 papers.
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