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SMPD4 (NM_017951) Human Untagged Clone

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SKU
SC112589
SMPD4 (untagged)-Human sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) (SMPD4), transcript variant 2
  $564.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol SMPD4
Synonyms NEDMABA; NEDMEBA; NET13; NSMASE-3; NSMASE3; SKNY
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>NCBI ORF sequence for NM_017951, the custom clone sequence may differ by one or more nucleotides


ATGACGACTTTCGGCGCCGTGGCGGAATGGCGGCTTCCATCTCTGAGGCGAGCGACGCTATGGATCCCAC
AGTGGTTTGCTAAGAAGGCCATTTTCAACTCTCCACTGGAGGCTGCTATGGCGTTCCCTCACCTGCAGCA
GCCCAGCTTTCTACTGGCTAGCCTGAAAGCTGACTCTATAAATAAGCCCTTTGCACAGCAGTGCCAAGAC
TTGGTTAAAGTCATTGAGGACTTTCCAGCAAAGGAGCTGCACACCATCTTCCCATGGCTGGTAGAAAGCA
TTTTTGGCAGCCTAGATGGTGTCCTCGTTGGCTGGAACCTCCGCTGCTTACAGGGGCGCGTGAATCCTGT
GGAGTACAGCATCGTGATGGAATTTCTCGACCCTGGTGGCCCAATGATGAAGTTGGTTTATAAGCTTCAA
GCTGAAGACTATAAGTTCGACTTTCCTGTCTCCTACTTGCCTGGTCCTGTGAAGGCGTCCATCCAGGAGT
GCATCCTCCCTGACAGTCCTCTGTACCACAACAAGGTCCAGTTCACCCCTACTGGGGGCCTTGGTCTGAA
CTTGGCCCTGAATCCGTTCGAGTATTACATATTCTTCTTTGCCTTGAGCCTCATCACTCAGAAGCCACTT
CCTGTGTCCCTCCACGTCCGTACTTCAGACTGTGCCTATTTCATCCTGGTGGACAGGTACCTGTCATGGT
TCCTGCCCACCGAAGGCAGTGTGCCCCCACCACTCTCCTCCAGCCCAGGGGGGACCAGCCCCTCACCACC
TCCCAGGACACCAGCCATACCCTTTGCTTCCTATGGCCTCCACCACACTAGCCTCCTAAAGCGACACATC
TCTCATCAGACGTCTGTGAATGCAGACCCCGCCTCCCACGAGATCTGGAGGTCAGAAACTCTGCTCCAGG
TTTTTGTTGAAATGTGGCTTCATCACTATTCCTTGGAGATGTATCAAAAAATGCAGTCCCCTCATGCCAA
GCTGGAGGTTCTGCACTACCGACTCAGTGTCTCCAGCGCCCTCTACAGCCCCGCCCAACCCAGCCTCCAG
GCCCTCCACGCCTACCAAGAGTCGTTCACGCCTACTGAGGAGCATGTGTTGGTGGTGCGCCTGCTGCTGA
AGCACCTGCACGCCTTTGCCAACAGCCTGAAGCCAGAGCAGGCCTCACCCTCCGCCCACTCCCACGCCAC
CAGCCCCCTGGAGGAGTTCAAACGGGCTGCTGTCCCGAGGTTCGTCCAGCAGAAACTCTACCTCTTCTTG
CAGCATTGCTTTGGCCACTGGCCCCTGGACGCATCGTTCAGAGCTGTCCTGGAGATGTGGCTGAGCTACC
TGCAGCCGTGGCGGTACGCGCCTGACAAGCAGGCTCCGGGCAGCGACTCCCAGCCCCGGTGTGTGTCGGA
GAAATGGGCACCCTTTGTCCAGGAGAACCTGCTGATGTACACCAAGTTGTTTGTGGGCTTTCTGAACCGC
GCGCTCCGCACAGACCTGGTCAGCCCCAAGCACGCGCTCATGGTGTTCCGAGTGGCCAAAGTCTTTGCCC
AGCCCAACCTGGCTGAGATGATTCAGAAAGGTGAGCAGCTATTCCTGGAGCCAGAGCTGGTCATCCCCCA
CCGCCAGCACCGACTCTTCACGGCCCCCACATTCACTGGGAGCTTCCTGTCACCCTGGCCACCAGCGGTC
ACTGATGCCTCCTTCAAGGTGAAGAGCCACGTCTACAGCCTGGAGGGCCAGGACTGCAAGTACACCCCGA
TGTTTGGGCCCGAGGCCCGCACCCTGGTCCTGCGCCTCGCTCAGCTCATCACACAGGCCAAACACACAGC
CAAGTCCATCTCCGACCAGTGTGCGGAGAGCCCGGCTGGCCACTCCTTCCTCTCATGGCTGGGCTTTAGC
TCCATGGACACCAATGGCTCCTACACAGCCAACGACCTGGACGAGATGGGGCAAGACAGTGTCCGGAAGA
CAGATGAATACCTGGAGAAGGCCCTGGAGTACCTGCGCCAGATATTCCGGCTCAGCGAAGCGCAGCTCAG
GCAGTTCACACTCGCCTTGGGCACCACCCAGGATGAGAATGGAAAAAAGCAACTCCCCGACTGCATCGTG
GGTGAGGACGGACTCATCCTTACGCCCCTGGGGCGGTACCAGATCATCAATGGGCTGCGAAGGTTTGAAA
TTGAGTACCAGGGGGACCCGGAGCTGCAGCCCATCCGGAGCTATGAGATCGCCAGCTTGGTCCGCACACT
CTTTAGGCTGTCGTCTGCCATCAACCACAGATTTGCAGGACAGATGGCGGCTCTGTGTTCCCGGGATGAC
TTCCTCGGCAGCTTCTGTCGCTACCACCTCACAGAACCTGGGCTGGCCAGCAGGCACCTGCTGAGCCCTG
TGGGGCGGAGGCAGGTGGCCGGCCACACCCGCGGCCCCAGGCTCAGCCTGCGCTTCCTGGGCAGTTACCG
GACGCTGGTCTCGCTGCTGCTGGCCTTCTTCGTGGCCTCTCTGTTCTGCGTCGGGCCCCTCCCATGCACG
CTGCTGCTCACCCTGGGCTATGTCCTCTACGCCTCTGCCATGACACTGCTGACCGAGCGGGGGAAGCTGC
ACCAGCCCTGA

5' Read Nucleotide Sequence
>OriGene 5' read for NM_017951 unedited
NNCCGTTCGAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGCGGAAT
GGCGGCTTCCATCTCTGAGGCGAGCGACGCTATGGATCCCACAGTGGTTTGCTAAGAAGG
CCATTTTCAACTCTCCACTGGAGGCTGCTATGGCGTTCCCTCACCTGCAGCAGCCCAGCT
TTCTACTGGCTAGCCTGAAAGCTGACTCTATAAATAAGCCCTTTGCACAGCAGTGCCAAG
ACTTGGTTAAAGTCATTGAGGACTTTCCAGCAAAGGAGCTGCACACCATCTTCCCATGGC
TGGTAGAAAGCATTTTTGGCAGCCTAGATGGTGTCCTCGTTGGCTGGAACCTCCGCTGCT
TACAGGGGCGCGTGAATCCTGTGGAGTACAGCATCGTGATGGAATTTCTCGACCCTGGTG
GCCCAATGATGAAGTTGGTTTATAAGCTTCAAGCTGAAGACTATAAGTTCGACTTTCCTG
TCTCCTACTTGCCTGGTCCTGTGAAGGCGTCCATCCAGGAGTGCATCCTCCCTGACAGTC
CTCTGTACCACAACAAGGTCCAGTTCACCCCTACTGGGGGCCTTGGTCTGAACTTGGCCC
TGAATCCGTTCGAGTATTACATATTCTTCTTTGCCTTGAGCCTCATCACTCAGAAGCCAC
TTCCTGTGTCCCTCCACGTCCGTACTTCAGACTGTGCCTATTTCATCCTGGTGGACAGGT
ACCTGTCATGGTTCCTGCCCACCGAAAGCAGTGTGCCCCCACCACTCTCCTCCAGCCCAG
GGGGACCAGCCCCTCACCACCTCCCAGACACCAGCCATACCCTTTGCTTCCTATGGCCTN
CACCACACTAGCCCTCCTAAGCGACACATCTCTCATCAGAN
3' Read Nucleotide Sequence
>OriGene 3' read for NM_017951 unedited
NGGCTAGGGGCATGAAACTTNATTTCCATGGTCGTTACAGCCTTCATTTTTGNGTCACAG
NGCCCTAAAATGCCATTATGCTCAGTTTACATCAAAATACAAAGCCCAACATTTACAATT
TCAAAAACATTAAAGCAAACCCCCAAAACCCCNACACCGAAAACAAAGGCTTGGTTTGGA
AATCACCACTGAGATGCTGTTCTCCCTCGCATGTCGCCTGTGGGGTGAATGAAGGTGAAG
ACCCCGTGCTGGTTTCTGTCAGAGAATCTGTAGTTGTATATTTTGAATACTTAAGTACCA
CTGAACGGTTGCCATGTCTTTGAGCACTTGATGTTACTGAAGTGACAATGCTTCTGACCA
TCTTTGGCTGCAGAGCAGAAACTGGCAGAATCCGACCCCATCGACCCAGCAGTGTCCCCA
ACGCCTGAGGACCAGCACCCATCTGTGACAAGGCACAGGGGTCCGCGATGTTGGCCACTG
CTTTGGGTGATGTGCTCAATGGCTTGGGGTCTGCGGTGAAGCCCCTGGGCTCTGGGAGGG
TCTTAGGCTCCTGAAACATGGAATTCTACGGCCCAGTCTTGGAACAGCTGGGAGAACATG
AAGAACGCCCCTCACAGTGAAGAATCAGGACAGCCACTCTCTGGTTTTCTCACAACTCTA
GAAACTTTGATTCTTTCCTGGAGTGGAGACTTAAACCCTGTCCCTGTCCCACCCAGAGAG
AGGAGCGCCCCAACCCACTCTGCCACCCTTAAGGCCGCCCGCGGGGGAAGCCAGGCCCAG
GTGGCTGTTTGCAGGCTGGCTCTCCAGCTTGGTGCAACAAAATACCCAAAGGGCCTGGGG
AAAAAAGGCCCCNAAGCTTGTTTGCCCCGAATCCTTGCCGAGGGAGGGAAAAGCCGCCCT
TAATCTTTGCCTTGCCAAAAAGTACTTTTGGACCTGTGAATACCCCTTCTTGGAGCCACC
CA
Restriction Sites NotI-NotI |
ACCN NM_017951
Insert Size 4080 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_017951.1, NP_060421.1
RefSeq Size 3920 bp
RefSeq ORF 1818 bp
Locus ID 55627
UniProt ID Q9NXE4
Cytogenetics 2q21.1
Protein Families Transmembrane
Protein Pathways Metabolic pathways, Sphingolipid metabolism
Summary The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. provided by RefSeq, Mar 2017
Transcript Variant: This variant (2) encodes the longest isoform (2). CCDS Note: This CCDS representation uses the 5'-most in-frame start codon. While this start codon is well-conserved, it should be noted that other than human and chimp, all other species have indels that follow this start codon. Other primates and rodents have frameshifting indels, and thus cannot use this start codon. However, some mammalian species, including cow, pig and dog, contain additional compensating indels that bring them back in frame; these species could therefore use the start codon represented in this CCDS. An alternative downstream start codon, which is more widely conserved and has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 39 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo.
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"NM_017951" in other vectors (5)
SKU Description Size Price
RC219824 SMPD4 (Myc-DDK-tagged)-Human sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) (SMPD4), transcript variant 2 10 ug
$1,189.00
RC219824L3 Lenti ORF clone of Human sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) (SMPD4), transcript variant 2, Myc-DDK-tagged 10 ug
$1,489.00
RC219824L4 Lenti ORF clone of Human sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) (SMPD4), transcript variant 2, mGFP tagged 10 ug
$1,489.00
RG219824 SMPD4 (tGFP-tagged) - Human sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) (SMPD4), transcript variant 2 10 ug
$1,389.00
SC318343 SMPD4 (untagged)-Human sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) (SMPD4), transcript variant 2 10 ug
$873.00

file-alt Citations

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