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PTP1B (PTPN1) (NM_002827) Human Untagged Clone

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SKU
SC110989
PTPN1 (untagged)-Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1)
  $457.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol PTP1B
Synonyms PTP1B
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC110989 sequence for NM_002827 edited (data generated by NextGen Sequencing)
ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTAC
CAGGATATCCGACATGAAGCCAGTGACTTCCCATGTAGAGTGGCCAAGCTTCCTAAGAAC
AAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT
CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGT
TACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGG
GAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA
TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTG
AAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTG
GAAAACCTTACAACCCAAGAAACTCGAGAGATCTTACATTTCCACTATACCACATGGCCT
GACTTTGGAGTCCCTGAATCACCAGCCTCATTCTTGAACTTTCTTTTCAAAGTCCGAGAG
TCAGGGTCACTCAGCCCGGAGCACGGGCCCGTTGTGGTGCACTGCAGTGCAGGCATCGGC
AGGTCTGGAACCTTCTGTCTGGCTGATACCTGCCTCTTGCTGATGGACAAGAGGAAAGAC
CCTTCTTCCGTTGATATCAAGAAAGTGCTGTTAGAAATGAGGAAGTTTCGGATGGGGCTG
ATCCAGACAGCCGACCAGCTGCGCTTCTCCTACCTGGCTGTGATCGAAGGTGCCAAATTC
ATCATGGGGGACTCTTCCGTGCAGGATCAGTGGAAGGAGCTTTCCCACGAGGACCTGGAG
CCCCCACCCGAGCATATCCCCCCACCTCCCCGGCCACCCAAACGAATCCTGGAGCCACAC
AATGGGAAATGCAGGGAGTTCTTCCCAAATCACCAGTGGGTGAAGGAAGAGACCCAGGAG
GATAAAGACTGCCCCATCAAGGAAGAAAAAGGAAGCCCCTTAAATGCCGCACCCTACGGC
ATCGAAAGCATGAGTCAAGACACTGAAGTTAGAAGTCGGGTCGTGGGGGGAAGTCTTCGA
GGTGCCCAGGCTGCCTCCCCAGCCAAAGGGGAGCCGTCACTGCCCGAGAAGGACGAGGAC
CATGCACTGAGTTACTGGAAGCCCTTCCTGGTCAACATGTGCGTGGCTACGGTCCTCACG
GCCGGCGCTTACCTCTGCTACAGGTTCCTGTTCAACAGCAACACATAG

Clone variation with respect to NM_002827.2
5' Read Nucleotide Sequence
>OriGene 5' read for NM_002827 unedited
AGGGCGGCCGCGAATTCGGCACGAGGGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGG
ATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTATAGCGGCAGACGGCGCAGTG
GGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGA
GCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAG
TGACTTCCCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGA
CGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAA
CGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTT
GCCTAACACATGCGGTCACTTTTGGGAGATGNGTGTGGGAGCAGAAAGCANGGGGTGTCG
TCATGCTCAACAGAGTGATGGAGAANAGGGTTCGTTAAAATGCGCACAATACTGGCCACA
AAAAGAAGAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGGA
GATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTTACACCCAAGAA
CTCGAGAGATCTTACATTTCACTATACCACATGGCCTGCTTTTTGGAGTCCCTGAATACC
AGCCTCATTCTTGAACTTTCTTTTACAAGTCCGAGAGTCAGGGTCACTCANCCCGGACCC
GGGCCCCCTTNGTGGTGCCCTGNAATGCAAGCCTTCGGAAGGGCTGGGACCCTTTTGGCT
GGGCGGATCCCTGCCTTTTGGTGAAGGACAAAAAGGAAGACCCTTCTTTCCGTGAATTAA
AAAAAGGGCTGGTAAAAAAAGGGAGAATTCGCGATGGGGGCC
3' Read Nucleotide Sequence
>OriGene 3' read for NM_002827 unedited
AGCTATGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTAGAAAAA
ATTTTATTGTTGCAGCTAAAATGCAAACCCATCATGAATATGGCAAGTTGGAAAACTGTA
CAGTCTGACAGTTCTGTGAGGTCACAGAAGACCCTGAGACACTCCCCCCCACCCACCCGG
TCATGCAGCCACGTATCCACACACACCTGAAAAGGTATTATACCAAAACACCTTGCTTTT
TTTGTTTTTATTTTTGTAAAAATGGTTTATTCCATGGCCATTGTAAAAAATAATGACCTG
ATGAGTAAATATTGGCTTAAGGCATATAGCAGAGCAGCTCGCTACCTCTCTAACATAATG
TGTAACAAGGTGGAGAGCCAGCTGCTCTCCAAGGATAGGAGGTTAAACCAGTACGTCCAT
TTTGAAATGCTACTATATATACACACCCAAACTACTACATACATATACAGGACTTAAAAA
CAACAAGCCCAGCTCAGAATGCTTACAGCCTGGCACCTAAGCCTTATCCACACCTCACCA
TAGCTCTGCAGGGTGACACCTCGAATGTTCCCACCACAGAATTTCTCTGTACTGGCTTCT
ACCACGAGAAAGGCAAAATGTGAAAATGCTGGCAAGAGAGTAGCTCGGGAGCTACAGCTG
CCGTGTTTTTCATGTTAAAAAGCCACTTAATGTGGAGGTCTTCAGTTCCCTTTGCAGGAA
GAGTCGTGAGCACCATCAGGCCCCACAGGGTTTGAGGGTGGGGCAGACGCGCCTCTCTCG
GNCAGGTGACCGGGACAGAGACGGCGGCAGGCTGCCTAAAGGACCGTCACCCAGNCTGTT
TCAAGAAGTGTGNTTTCCAGCAGGTGCCCTCTCTTCCAATCACGGTCTGCTCAAGAGAAG
GTTGACTTGGAATGGCGGAGGCTGATCCACAAGTTGGGGGCGGGGGGTGTCCCTGCTTCC
TAAATATGTCCAGACGGA
Restriction Sites NotI-NotI |
ACCN NM_002827
Insert Size 3520 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_002827.2, NP_002818.1
RefSeq Size 3318 bp
RefSeq ORF 1308 bp
Locus ID 5770
UniProt ID P18031
Cytogenetics 20q13.13
Domains PTPc_motif, Y_phosphatase
Protein Families Druggable Genome, Phosphatase, Transmembrane
Protein Pathways Adherens junction, Insulin signaling pathway
Summary The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2013
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
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Documents
Resources
"NM_002827" in other vectors (6)
SKU Description Size Price
RC204902 PTPN1 (Myc-DDK-tagged)-Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1) 10 ug
$457.00
RC204902L1 Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1), Myc-DDK-tagged 10 ug
$757.00
RC204902L2 Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1), mGFP tagged 10 ug
$757.00
RC204902L3 Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1), Myc-DDK-tagged 10 ug
$757.00
RC204902L4 Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1), mGFP tagged 10 ug
$757.00
RG204902 PTPN1 (tGFP-tagged) - Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1) 10 ug
$489.00 $657.00

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