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KCNK1 (NM_002245) Human Untagged Clone

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SKU
SC110937
KCNK1 (untagged)-Human potassium channel, subfamily K, member 1 (KCNK1)
  $457.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol KCNK1
Synonyms DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1; TWIK1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC110937 sequence for NM_002245 edited (data generated by NextGen Sequencing)
ATGCTGCAGTCCCTGGCCGGCAGCTCGTGCGTGCGCCTGGTGGAGCGGCACCGCTCGGCC
TGGTGCTTCGGCTTCCTGGTGCTGGGCTACTTGCTCTACCTGGTCTTCGGCGCAGTGGTC
TTCTCCTCGGTGGAGCTGCCCTATGAGGACCTGCTGCGCCAGGAGCTGCGCAAGCTGAAG
CGACGCTTCTTGGAGGAGCACGAGTGCCTGTCTGAGCAGCAGCTGGAGCAGTTCCTGGGC
CGGGTGCTGGAGGCCAGCAACTACGGCGTGTCGGTGCTCAGCAACGCCTCGGGCAACTGG
AACTGGGACTTCACCTCCGCGCTCTTCTTCGCCAGCACCGTGCTCTCCACCACAGGTTAT
GGCCACACCGTGCCCTTGTCAGATGGAGGTAAGGCCTTCTGCATCATCTACTCCGTCATT
GGCATTCCCTTCACCCTCCTGTTCCTGACGGCTGTGGTCCAGCGCATCACCGTGCACGTC
ACCCGCAGGCCGGTCCTCTACTTCCACATCCGCTGGGGCTTCTCCAAGCAGGTGGTGGCC
ATCGTCCATGCCGTGCTCCTTGGGTTTGTCACTGTGTCCTGCTTCTTCTTCATCCCGGCC
GCTGTCTTCTCAGTCCTGGAGGATGACTGGAACTTCCTGGAATCCTTTTATTTTTGTTTT
ATTTCCCTGAGCACCATTGGCCTGGGGGATTATGTGCCTGGGGAAGGCTACAATCAAAAA
TTCAGAGAGCTCTATAAGATTGGGATCACGTGTTACCTGCTACTTGGCCTTATTGCCATG
TTGGTAGTTCTGGAAACCTTCTGTGAACTCCATGAGCTGAAAAAATTCAGAAAAATGTTC
TATGTGAAGAAGGACAAGGACGAGGATCAGGTGCACATCATAGAGCATGACCAACTGTCC
TTCTCCTCGATCACAGACCAGGCAGCTGGCATGAAAGAGGACCAGAAGCAAAATGAGCCT
TTTGTGGCCACCCAGTCATCTGCCTGCGTGGATGGCCCTGCAAACCATTGA

Clone variation with respect to NM_002245.3
5' Read Nucleotide Sequence
>OriGene 5' read for NM_002245 unedited
GTCTTTGGGATTTTGTAACACGATTCACTATAGGGCGGACCGCGAATTCGCACGAGGCGG
CGGGCCGCGCTCCGGCCGGTCTGCGGCGTTGGCCTTGGCGGCGGCGGTGGAGAAGATGCT
GCAGTCCCTGGCCGGCAGCTCGTGCGTGCGCCTGGTGGAGCGGCACCGCTCGGCCTGGTG
CTTCGGCTTCCTGGTGCTGGGCTACTTGCTCTACCTGGTCTTCGGCGCAGTGGTCTTCTC
CTCGGTGGAGCTGCCCTATGAGGACCTGCTGCGCCAGGAGCTGCGCAAGCTGAAGCGACG
CTTCTTGGAGGAGCACGAGTGCCTGTCTGAGCAGCAGCTGGAGCAGTTCCTGGGCCGGGT
GCTGGAGGCCAGCAACTACGGCGTGTCGGTGCTCAGCAACGCCTCGGGCAACTGGAACTG
GGACTTCACCTCCGCGCTCTTCTTCGCCAGCACCGTGCTCTCCACCACAGGTTATGGCCA
CACCGTGCCCTTGTCAGATGGAGGTAAGGCCTTCTGCATCATCTACTCCGTCATTGGCAT
TCCCTTCACCCTCCTGTTCCTGACGGCTGTGGTCCAGCGCATCACCGTGCACGTCACCCG
CAGGCCGGTCCTCTACTTCCACATCCGCTGGGGCTTCTCCAAGCAAGTGGTGGCCATCGT
CCATGCCGTGCTCCTTGAGTTTGTCACTGTGTCCTGCTTCTTCTCATCCCGGCCGCTGTC
TTCTCAGTCCTGGAGGATGACTGGAACTTNCCTGGATCCTTTATTTTAGTTTATTTCCCT
GAGCACCATTGGCCTGGGGGATTATGTGCCTGGGGAAAGGCTACATCAAAATTCAGAGAG
CTCTATAGATTGGGATCACGTGTTACCTGCTACTTGGCCCTATTGCCTGTTGGTAGTNCT
GGAAACCTTCTGTGGACTCATGAGCCTGAAAAATTCAGAAAAATGTCTAGTG
3' Read Nucleotide Sequence
>OriGene 3' read for NM_002245 unedited
GAACGCGGCACGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCGCAGAAGGTAGAAA
CATTTATTGCAGCAGAATACTATGGTTATTCACTCTCAAGTTTATTATTCCCCTTATTTT
ATTGTAGCAACTCTGGATTCTTTAGTATAAAGAGAAATCAAAAGAAACAAAATATCTATA
GTCTTAGTTTCAGAACTACACTAGGATCTGGTGACCTAAACCATATGTACAGAATATAAA
CATATTTATACTTTATATGTACATAGTTAATGGTTACCTATGCATTATAAATAGTAAGTT
TAACTTAAATTCTACAAAAATAATCATTTTGGGTGGGTACATGCAAACCAGTACACATAA
ACCTATTTATAAAACACATCTCTATGCTTTTTTTTTTTGCTTCTAAATATAAATTTTGCT
ATTTAGCCATCAGCTAAATGATCTAAATGCAAACCCCAAAGTTTCCAGTTAAAAGTATAA
AATCTGCTTCTAACCACAGCAGCATACTGCTTCAAGTATTCTCCTCCTATGTAAGGTCGA
GATAATTTTGTCACATATGAATTTTAGGTGGACATCTCATTTCCTCACATATTAGACATC
CTGCTGGGGTCACAGCTTCTTTGTTCCATTTGGCTTTTTTTGTTGTTTTTTAATAAGACA
TTGCAAACAGTAGCTATTTCTTAAAGTGACATAATTTTCGCTTTTGCATTCTGATAAAAA
TGAACATACTTAAGCCTCTTCCTTGCACCCTGACCCTGNTGCTCTAGCATAATGCAACAA
ATCCTACGCTCAATGGGTTGCAAGGCCATCCAGCAGGCAGATGACTGGGTGGCCACAAAA
AGCTCATTTTGCTNCTGGGCCTCTTTCATGCCAACTGGCTGGTCTGTGATCGAGGAAAAG
GACAGTTGCCATGCTCTAATGAGGGCACTGAN
Restriction Sites NotI-NotI |
ACCN NM_002245
Insert Size 1870 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_002245.2, NP_002236.1
RefSeq Size 1901 bp
RefSeq ORF 1011 bp
Locus ID 3775
UniProt ID O00180
Cytogenetics 1q42.2
Protein Families Druggable Genome, Ion Channels: Potassium, Transmembrane
Summary This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. provided by RefSeq, Jul 2008
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Documents
Resources
"NM_002245" in other vectors (4)
SKU Description Size Price
RC205321 KCNK1 (Myc-DDK-tagged)-Human potassium channel, subfamily K, member 1 (KCNK1) 10 ug
$457.00
RC205321L3 Lenti ORF clone of Human potassium channel, subfamily K, member 1 (KCNK1), Myc-DDK-tagged 10 ug
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RC205321L4 Lenti ORF clone of Human potassium channel, subfamily K, member 1 (KCNK1), mGFP tagged 10 ug
$757.00
RG205321 KCNK1 (tGFP-tagged) - Human potassium channel, subfamily K, member 1 (KCNK1) 10 ug
$489.00 $657.00

file-alt Citations

Noradrenergic depression of neuronal excitability in the entorhinal cortex via activation of TREK-2 K+ channels
Xiao, Deng, Rojanathammanee et al
J Biol Chem (2009) 284 (16), 10980-91 DOI: 10.1074/jbc.M806760200
AI Summary: In this study, OriGene’s mouse Trek2 (Kcnk10) Myc-DDK-tagged cDNA clone (Cat# MR207771) was used to express TREK-2 channels, enabling the authors to investigate the molecular mechanisms by which norepinephrine modulates neuronal excitability in the entorhinal cortex.
Serotonin inhibits neuronal excitability by activating two-pore domain k+ channels in the entorhinal cortex
Deng, Poudel, Rojanathammanee et al
Mol Pharmacol (2007) 72 (1), 208-18 DOI: 10.1124/mol.107.034389
Cited by 61
AI Summary: In this paper, OriGene’s mouse Gnai3 shRNA plasmid (Cat# TG502227) was used to knock down Galpha(i3) expression, helping to demonstrate the requirement of the Galpha(i3) subunit in serotonin-mediated inhibition of neuronal excitability in the entorhinal cortex.
Showing 1-2 of 2 papers.
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