alpha 2 Macroglobulin (A2M) (NM_000014) Human Untagged Clone
$1,262.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | alpha 2 Macroglobulin |
| Synonyms | A2MD; CPAMD5; FWP007; S863-7 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_000014 |
| Insert Size | 5150 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_000014.4, NP_000005.2 |
| RefSeq Size | 4678 bp |
| RefSeq ORF | 4425 bp |
| Locus ID | 2 |
| UniProt ID | P01023 |
| Cytogenetics | 12p13.31 |
| Domains | A2M, A2M_N |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Complement and coagulation cascades |
| Summary | The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. provided by RefSeq, Nov 2016 Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode isoform a. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_000014" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC207905 | A2M (Myc-DDK-tagged)-Human alpha-2-macroglobulin (A2M) | 10 ug |
$1,261.00
|
|
| RC207905L1 | Lenti ORF clone of Human alpha-2-macroglobulin (A2M), Myc-DDK-tagged | 10 ug |
$1,561.00
|
|
| RC207905L2 | Lenti ORF clone of Human alpha-2-macroglobulin (A2M), mGFP tagged | 10 ug |
$1,561.00
|
|
| RC207905L3 | Lenti ORF clone of Human alpha-2-macroglobulin (A2M), Myc-DDK-tagged | 10 ug |
$1,561.00
|
|
| RC207905L4 | Lenti ORF clone of Human alpha-2-macroglobulin (A2M), mGFP tagged | 10 ug |
$1,561.00
|
|
| RG207905 | A2M (tGFP-tagged) - Human alpha-2-macroglobulin (A2M) | 10 ug |
$789.00
$1,461.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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