CCR2 (NM_000648) Human Untagged Clone
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | CCR2 |
| Synonyms | CC-CKR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_000648 |
| Insert Size | 3600 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_000648.1, NP_000639.1 |
| RefSeq Size | 1979 bp |
| RefSeq ORF | 1083 bp |
| Locus ID | 1231 |
| Cytogenetics | 3p21.31 |
| Domains | 7tm_1 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Summary | This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. provided by RefSeq Transcript Variant: This variant (B) lacks the 3' exon but has an alternate 3' segment, as compared to transcript A. It encodes the predominant isoform (B) which localizes to the plasma membrane. Isoform B has a distinct C-terminus and is 14 aa shorter than isoform A. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_000648" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC221283 | CCR2 (Myc-DDK-tagged)-Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant B | 10 ug |
$457.00
|
|
| RC221283L1 | Lenti ORF clone of Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC221283L2 | Lenti ORF clone of Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, mGFP tagged | 10 ug |
$757.00
|
|
| RC221283L3 | Lenti ORF clone of Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC221283L4 | Lenti ORF clone of Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, mGFP tagged | 10 ug |
$757.00
|
|
| RG221283 | CCR2 (tGFP-tagged) - Human chemokine (C-C motif) receptor 2 (CCR2), transcript variant B | 10 ug |
$489.00
$657.00
|
|
Citations
The lupane-type triterpene 30-oxo-calenduladiol is a CCR5 antagonist with anti-HIV-1 and anti-chemotactic activities
Barroso-González, El Jaber-Vazdekis, García-Expósito et al
J Biol Chem (2009) 284 (24), 16609-16620 DOI: 10.1074/jbc.M109.005835
Barroso-González, El Jaber-Vazdekis, García-Expósito et al
J Biol Chem (2009) 284 (24), 16609-16620 DOI: 10.1074/jbc.M109.005835
AI Summary: In this study, OriGene’s TrueORF cDNA clones for human CCR5, CCR1, CCR2b, CCR3, and CCR4 were used to express these receptors in cell-based assays, enabling the researchers to evaluate the specificity and mechanism of action of 30-oxo-calenduladiol as a selective CCR5 antagonist with anti-HIV-1 activity.
Showing 1-1 of 1 papers.
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