CD68 Mouse Monoclonal Antibody [Clone ID: UMAB150]
Specifications
| Product Data | |
| Clone Name | UMAB150 |
|---|---|
| Application | 10k-ChIP, IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:100~200 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22-319 of human CD68 (NP_001242)produced in SF9 cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1.0 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | CD68 molecule |
| Database Link | |
| Background | This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. provided by RefSeq, Jul 2008 |
| Synonyms | GP110; LAMP4; SCARD1 |
| Reference Data | |
| Protein Categories | ADC Targets, CD Markers, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Lysosome |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "UMAB150" antibodies (2)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| UM800047 | CD68 mouse monoclonal antibody,clone UMAB150 | 100 ul |
$610.00
|
|
| UM800047CF | Carrier-free (BSA/glycerol-free) CD68 mouse monoclonal antibody,clone UMAB150 | 100 ug |
$680.00
|
|
Citations
Sex Differences in Expression of Pro-Inflammatory Markers and miRNAs in a Mouse Model of CVB3 Myocarditis
Estepa, Niehues, Vakhrusheva et al
Int J Mol Sci (2024) 25 (17) DOI: 10.3390/ijms25179666
Estepa, Niehues, Vakhrusheva et al
Int J Mol Sci (2024) 25 (17) DOI: 10.3390/ijms25179666
Cited by 5
AI Summary: In this study, the CD68 antibody from OriGene was used to characterize infiltrating immune cells in heart tissue, aiding the analysis of inflammatory responses in a mouse model of CVB3-induced myocarditis.
Snippet: of vision in x200 original magnification) and then averaged. All sections were blindly evaluated by three different investigators, as described in [24]. To characterize the infiltrated cells, CD68 (OriGene Technologies GmbH, Herford, Germany), CD11b (Novus Biologicals, Bio-Techne GmbH, Wiesbaden, Germany) and CD8 (Clone MA5, Invitrogen, Thermo Fischer Scientific, Darmstadt, Germany) antibodies w
Inhibition of Canonical Transient Receptor Potential 5 Channels Polarizes Macrophages to an M1 Phenotype
Tao, Guo, Qi et al
Pharmacology (2019)
Tao, Guo, Qi et al
Pharmacology (2019)
AI Summary: In this study, OriGene Technologies contributed primary antibodies for CD68, which were used to identify and analyze macrophage populations during experiments on TRPC5 channel inhibition and macrophage polarization.
Snippet: Reagents LPS and ML204 (a TRPC4/5 inhibitor) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Primary antibodies for CD68 were obtained from Origene Technologies (Rockville, MD, USA). Primary antibodies for Akt, phosphorylated (p)-Akt (ser473)
M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia
Sheng, Yang, Cui et al
Cell Death Dis (2018) 9 (7), 755 DOI: 10.1038/s41419-018-0744-1
Sheng, Yang, Cui et al
Cell Death Dis (2018) 9 (7), 755 DOI: 10.1038/s41419-018-0744-1
AI Summary: OriGene’s CD68 antibody (UM800047) was used in this study to assess macrophage infiltration in prostate tissue samples, helping to elucidate the role of M2 macrophages in the progression of benign prostatic hyperplasia.
Snippet: Page 12. the percentages of collagen I-positive area with the intensity score. Additionally, we determined the number of CD68 + clusters by using the CD68 antibody (OriGene, MA, USA;UM800047, 1:200 dilution) to evaluate the degree of macrophage infiltration
Fasudil, a Rho‑kinase inhibitor, prevents intima‑media thickening in a partially ligated carotid artery mouse model: Effects of fasudil in flow‑induced vascular remodeling
Zhang, Zhang, Gao et al
Mol Med Rep (2015) 12 (5), 7317-25 DOI: 10.3892/mmr.2015.4409
Zhang, Zhang, Gao et al
Mol Med Rep (2015) 12 (5), 7317-25 DOI: 10.3892/mmr.2015.4409
Cited by 13
Showing 1-4 of 4 papers.
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