PD1 (PDCD1) Mouse Monoclonal Antibody [Clone ID: UMAB197]
Specifications
| Product Data | |
| Clone Name | UMAB197 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | IHC 1:200, WB 1:500, IF 1:100.. |
| Reactivity | Dog, Human, Monkey, Mouse, Rabbit, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human PDCD1 (NP_005009) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 0.5~1.0 mg/ml (Lot Dependent) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 29.2 kDa |
| Gene Name | programmed cell death 1 |
| Database Link | |
| Background | This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul |
| Synonyms | CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2 |
| Reference Data | |
| Protein Categories | ADC Targets, Allergies and autoimmune diseases, CD Markers, Intracellular Proteins, Membrane Proteins, Nervous system Diseases |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), T cell receptor signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "UMAB197" antibodies (2)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| UM800089CF | Carrier-free (BSA/glycerol-free) PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB197 | 100 ug |
$680.00
|
|
| UM870089 | PD-1 (PDCD1) mouse monoclonal antibody,clone UMAB197 | 30 ul |
$224.00
|
|
Citations
Intratumoral expression analysis reveals that OX40 and TIM‑3 are prominently expressed and have variable associations with clinical outcomes in high grade serous ovarian cancer
James, Valenzuela, Emerson et al
Oncol Lett (2022) 23 (6), 188 DOI: 10.3892/ol.2022.13308
James, Valenzuela, Emerson et al
Oncol Lett (2022) 23 (6), 188 DOI: 10.3892/ol.2022.13308
Cited by 8
AI Summary: OriGene products, including primary antibodies against CD8 (TA802079), CD4 (UM800010), PD-1 (UM870089), OX40 (UM870166), BTLA (TA505536), and TIM-3 (TA), were used for immunofluorescence staining to assess the expression of immune receptors in high grade serous ovarian cancer tissue samples in this study.
Snippet: 1200). A representative image of immune receptor co-staining with DAPI can be seen in Fig. S1. Primary antibodies were all used at a [1:50] dilution, with vendor and catalog numbers as follows: CD8 (Origene TA802079 and Abcam ab4055), CD4 (Origene, UM800010 and Abcam ab133616), PD-1 (Origene, UM870089), OX40 (Origene UM870166), BTLA (Origene, TA505536), CD137 (Abcam, ab232990), TIM-3 (Origene, TA
Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model
Berz, Santana, Iseke et al
J Vasc Interv Radiol (2022) 33 (7), 764-774.e4 DOI: 10.1016/j.jvir.2022.03.026
Berz, Santana, Iseke et al
J Vasc Interv Radiol (2022) 33 (7), 764-774.e4 DOI: 10.1016/j.jvir.2022.03.026
Cited by 13
AI Summary: OriGene products—specifically the CTLA-4 antibody (UM800141), PD-1 antibody (UM800089), and PD-L1 antibody (UM800121)—were used for immunohistochemical detection and quantification of immune checkpoint marker expression in tumor tissues, enabling assessment of immune response differences among TACE regimens in the study.
Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing
Bosisio, Antoranz, van Herck et al
Elife (2020) 9 DOI: 10.7554/eLife.53008
Bosisio, Antoranz, van Herck et al
Elife (2020) 9 DOI: 10.7554/eLife.53008
AI Summary: In this study, OriGene products Ki-67 (UMAB107), Lysozyme, and PD-1 (UMAB197) antibodies were used for immunohistochemical analysis to characterize immune cell populations and their functional states within primary melanoma tissue.
Snippet: Antibody CD56 mouse monoclonal IgG1 123C3.D5 Neomarkers AB_627127 1 µg/ml Antibody Ki-67 mouse monoclonal IgG2a UMAB107 Origene AB_2629145 2 µg/ml Antibody Lysozyme rabbit polyclonal Origene AB_1004766 1 µg/ml Antibody PD-1 mouse monoclonal IgG2a UMAB197 Origene AB_2629198 1 µg/ml Antibody TIM3 goat polyclonal R and D AB_355235 1 µg/ml Antibody CXCL13 mouse monoclonal IgG1 53610 R and D AB_2086049 1 µg/ml
Showing 1-3 of 3 papers.
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