CD1C Mouse Monoclonal Antibody [Clone ID: UMAB46]
Specifications
| Product Data | |
| Clone Name | UMAB46 |
|---|---|
| Application | 10k-ChIP, IHC, WB |
| Recommended Dilution | IHC 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human CD1C(NP_001756) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 0.5~1.0 mg/ml (Lot Dependent) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 35.7 kDa |
| Gene Name | CD1c molecule |
| Database Link | |
| Background | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul |
| Synonyms | BDCA1; CD1; CD1A; R7 |
| Reference Data | |
| Protein Categories | ADC Targets, CD Markers, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Hematopoietic cell lineage |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "UMAB46" antibodies (2)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| UM500042 | CD1C mouse monoclonal antibody,clone UMAB46 | 100 ul |
$610.00
|
|
| UM500042CF | Carrier-free (BSA/glycerol-free) CD1C mouse monoclonal antibody,clone UMAB46 | 100 ug |
$680.00
|
|
Citations
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells
Thakore, Schnell, Huang et al
Nat Immunol (2024) 25 (8), 1395-1410 DOI: 10.1038/s41590-024-01901-1
Thakore, Schnell, Huang et al
Nat Immunol (2024) 25 (8), 1395-1410 DOI: 10.1038/s41590-024-01901-1
Cited by 54
AI Summary: OriGene’s BACH2 open reading frame (MR224703) was used to overexpress BACH2 in TH17 cells, enabling the authors to investigate its role in regulating chromatin states and cell differentiation.
Snippet: For retrovirus production, HEK293T cells were transfected with gag/pol (1 μg ml–1;Addgene, 14887) and pCL-Eco (0.5 ng ml–1;Addgene, 12371) retroviral plasmids and the transfer plasmids containing Bach2-targeting gRNA or nontargeting gRNA (retro-gRNA-mRFP1, 1.3 μg ml–1, marked by dsRed) and Bach2 open reading frame (Origene, MR224703;cloned into Addgene 52107, 1 μg ml–1, marked by GFP) using X-tremeGENE transfection reagent (Sigma-Aldrich) following the manufacturer’s directions
A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma
Pozniak, Pedri, Landeloos et al
Cell (2024) 187 (1), 166-183.e25 DOI: 10.1016/j.cell.2023.11.037
Pozniak, Pedri, Landeloos et al
Cell (2024) 187 (1), 166-183.e25 DOI: 10.1016/j.cell.2023.11.037
Cited by 197
AI Summary: OriGene’s Anti-Human CD1C antibody (Cat# UM500042) was used in immunofluorescence assays to help characterize immune cell populations within the melanoma tumor microenvironment in this study.
Snippet: IF MILAN: Anti-Human CD16 Novocastra Cat# NCL-CD16;RRID: AB_563508 IF MILAN: Anti-Human CD163 abcam Cat# ab182422;RRID: AB_2753196 IF MILAN: Anti-Human CD1C Origene Cat# UM500042;RRID: AB_2629056 IF MILAN: Anti-Human CD20 Dako Cat# M075501-2 IF MILAN: Anti-Human CD206 R&D Cat# AF2534;RRID: AB_2063019 IF MILAN: Anti-Human CD3 ThermoFisher Scientific Cat# MA1-90582;RRID: AB_1956722
NOT ALL ANTIBODIES HAVE BEEN CREATED EQUAL: Antibodies validated for routinely processed tissue seldom apply to frozen tissue sections
Bolognesi, Mascadri, Perego et al
bioRxiv (2020)
Bolognesi, Mascadri, Perego et al
bioRxiv (2020)
Snippet: g1 CD1A O10 SCBT yes 626957 + + neg conformational historic g1 CD1c 2F4 Origene yes 2623067 neg neg neg neg orthogonal g1 CD1c 2D4 Origene yes 2623049 neg neg neg neg orthogonal g1 CD1c UMAB46 Origene yes 2629056 neg neg neg neg peptide microarray, orthogonal g2A CD2 B-8 SCBT yes 2073673 neg neg neg neg g2A CD20 L26 Dako yes 2282030 + + + conserved historic
Showing 1-3 of 3 papers.
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