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DUSP1 Rabbit Polyclonal Antibody

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SKU
TA890036S
Rabbit polyclonal anti-DUSP1 Antibody
Size:
30 ul 100 ul
Conjugation:
Unconjugated
  $188.00
In Stock*
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Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB: 1:500~1:1000
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human DUSP1
Buffer PBS (pH 7.3) containing 50% glycerol and 0.02% sodium azide
Concentration 1.47mg/ml
Purification Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 39.1 kDa
Gene Name dual specificity phosphatase 1
Database Link
Background The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. provided by RefSeq, Jul 2008
Synonyms CL100; HVH1; MKP-1; MKP1; PTPN10
Reference Data
Protein Categories Chemokines, Intracellular Proteins
Protein Families Druggable Genome, Phosphatase
Protein Pathways MAPK signaling pathway
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Documents
Resources
Other antibodies (1)
SKU Description Size Price
TA890036 Rabbit polyclonal anti-DUSP1 Antibody 100 ul
$407.00

file-alt Citations

MicroRNA-760-mediated low expression of DUSP1 impedes the protective effect of NaHS on myocardial ischemia-reperfusion injury
Ren, Wang, Ma et al
Biochem. Cell Biol. (2020)
Cited by 15
AI Summary: In this study, the OriGene DUSP1 antibody (TA890036S) was used to detect DUSP1 protein levels, helping to elucidate the molecular mechanisms by which miR-760 affects myocardial ischemia-reperfusion injury.
Snippet: 156 Technology, USA), cleaved PARP (#5625, 1:1000, CST, USA), GAPDH (#5174, 157 1:1000, CST, USA) and DUSP1 (TA890036S, 1:1000, ORIGENE, USA) were 158 incubated with membranes overnight at 4 °C. Thereafter, membranes were incubated
WB
Showing 1-1 of 1 papers.
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