UAP56 (DDX39B) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB: 1:500~1:1000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human DDX39B |
| Buffer | PBS (pH 7.3) containing 50% glycerol and 0.02% sodium azide |
| Concentration | 1.95mg/ml |
| Purification | Purified from the immunized serum by affinity chromatography (Protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 48.8 kDa |
| Gene Name | DEAD-box helicase 39B |
| Database Link | |
| Background | This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. provided by RefSeq, Feb 2011 |
| Synonyms | BAT1; D6S81E; UAP56 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Pathways | Spliceosome |
Reviews
Documents
| Product Manuals |
| FAQs |
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Resources
Other antibodies (1)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA890032 | Rabbit polyclonal anti-DDX39B Antibody | 100 ul |
$407.00
|
|
Citations
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components
Lester, Ooi, Bakkar et al
Neuron (2021) 109 (10), 1675-1691.e9 DOI: 10.1016/j.neuron.2021.03.026
Lester, Ooi, Bakkar et al
Neuron (2021) 109 (10), 1675-1691.e9 DOI: 10.1016/j.neuron.2021.03.026
Cited by 228
AI Summary: In this study, the OriGene Rabbit anti-DDX39B antibody (Cat #: TA890032) was used to investigate the localization and involvement of DDX39B in tau aggregate-associated alterations of nuclear speckle components.
Snippet: Rabbit anti-ZC3H14 (MSUT2) Sigma-Aldrich Cat #: HPA049798;RRID:AB_2680888 Rabbit anti-DDX39B OriGene Cat #: TA890032 Rabbit anti-DYRK1A Abcam Cat #: ab65220;RRID:AB_1140733 Rabbit anti-SRSF2 Abcam Cat #: ab204916 Rabbit anti-SNRNP70 (U1-70K) Abcam Cat #: ab83306;RRID:AB_10673827 Rabbit anti-PABP Abcam Cat #: ab21060;RRID:AB_777008
Tau aggregates are RNA-protein assemblies that mis-localize multiple nuclear speckle components
Lester, Ooi, Bakkar et al
bioRxiv (2021)
Lester, Ooi, Bakkar et al
bioRxiv (2021)
Cited by 13
Showing 1-2 of 2 papers.
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