MSH6 Mouse Monoclonal Antibody [Clone ID: OTI5D1]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI5D1 |
|---|---|
| Application | IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1-280 of human MSH6(NP_000170) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | mutS homolog 6 |
| Database Link | |
| Background | This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. provided by RefSeq, Jul 2013 |
| Synonyms | GTBP; GTMBP; HNPCC5; HSAP; MMRCS3; p160 |
| Reference Data | |
| Protein Categories | Cancer: Gastrointestinal, Intracellular Proteins |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
| Protein Pathways | Colorectal cancer, Mismatch repair, Pathways in cancer |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI5D1" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF807929 | Carrier-free (BSA/glycerol-free) MSH6 mouse monoclonal antibody,clone OTI5D1 | 100 ug |
$620.00
|
|
| TA807929AM | MSH6 mouse monoclonal antibody,clone OTI5D1, Biotinylated | 100 ul |
$509.00
|
|
| TA807929BM | MSH6 mouse monoclonal antibody,clone OTI5D1, HRP conjugated | 100 ul |
$509.00
|
|
| TA807929S | MSH6 mouse monoclonal antibody,clone OTI5D1 | 30 ul |
$200.00
|
|
Citations
B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation
Stoler-Barak, Harris, Peres et al
Nat Commun (2023) 14 (1), 1462 DOI: 10.1038/s41467-023-37205-5
Stoler-Barak, Harris, Peres et al
Nat Commun (2023) 14 (1), 1462 DOI: 10.1038/s41467-023-37205-5
Cited by 14
AI Summary: In this study, OriGene products—including the MSH6 antibody (TA807929) for western blotting and recombinant MSH6 protein for kinase assays—were used to investigate DYRK1A’s role in regulating B cell class switch recombination through MSH6 phosphorylation.
Snippet: stern blot Beta-actin 1:1000 D6A8 Cell Signaling CTS-84575 DYRK1A 1:1000 D30C10 Cell Signaling CTS-87655 DYRK1A 1:1000 7D10 Abnova H00001859-M01 MSH6 1:1000 OTI5D1 Origene TA807929 Thiophosphate ester 1:5000 51-8 Abcam ab92570 HRP anti-mouse IgG 1:10,000 NXA931 Cytiva NXA931 HRP anti-rabbit 1:10,000 NA934 Cytiva NA934 ELISA Serum was;Overall, 100 ng of recombinant DYRK1A (ThermoScientific), 5 mg of recombinant MSH6 (Origene), 200 μM ATP-g-S (Abcam), and kinase buffer (40 mM Tris, pH 7.5, 10 mM MgCl2, 50 mM NaCl) were combined in a 30 μL reaction
Showing 1-1 of 1 papers.
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