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PAK4 Mouse Monoclonal Antibody [Clone ID: OTI1C7]

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SKU
TA807297
PAK4 mouse monoclonal antibody, clone OTI1C7 (formerly 1C7)
Size:
100 ul 30 ul
Formulation:
Standard Carrier-free
Conjugation:
Unconjugated Biotin HRP
  $447.00
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View other "PAK4 or NM_005884" antibodies

Specifications
Specifications
Product Data
Clone Name OTI1C7
Application IHC, WB
Recommended Dilution WB 1:2000, IHC 1:150
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 1-308 of human PAK4(NP_005875) produced in E.coli.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 63.9 kDa
Gene Name p21 (RAC1) activated kinase 4
Database Link
Background PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. provided by RefSeq, Jul 2008
Reference Data
Protein Categories Enzyme: Kinases, Intracellular Proteins
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Axon guidance, ErbB signaling pathway, Focal adhesion, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway
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Other "OTI1C7" antibodies (4)
SKU Description Size Price
CF807297 Carrier-free (BSA/glycerol-free) PAK4 mouse monoclonal antibody, clone OTI1C7 (formerly 1C7) 100 ug
$620.00
TA807297AM PAK4 mouse monoclonal antibody, clone OTI1C7 (formerly 1C7), Biotinylated 100 ul
$509.00
TA807297BM PAK4 mouse monoclonal antibody, clone OTI1C7 (formerly 1C7), HRP conjugated 100 ul
$509.00
TA807297S PAK4 mouse monoclonal antibody, clone OTI1C7 (formerly 1C7) 30 ul
$200.00

file-alt Citations

β2-Adrenergic receptor regulates osteoblast differentiation and migration and C-terminal β-catenin phosphorylation
Worton, Curtin, Gardiner
Biochem Biophys Res Commun (2025) 781, 152490 DOI: 10.1016/j.bbrc.2025.152490
Cited by 6
Snippet: The following antibodies were used in this study;β-catenin (BD Biosciences, cat# 61053), β-catenin pSer552 (Cell Signaling Technology, cat# 5651), β-catenin pSer675 (Cell Signaling Technology, cat# 4176), PAK4 (Origene, cat# TA807297),
IP
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
Costa, Zhuang, Lorent et al
Nat Commun (2019) 10 (1), 3589 DOI: 10.1038/s41467-019-11510-4
AI Summary: In this study, OriGene products—specifically the PAK4 shRNA (OriGene, #TF314627) and PAK4 cDNA plasmid (OriGene, #RC204307)—were used to manipulate PAK4 expression levels in breast cancer cells, enabling the authors to investigate PAK4's role in suppressing RELB and preventing senescence-like growth arrest.
Snippet: gnosis in several cancer forms10. Yet, the potential functional role of PAK4 during cancer development in vivo has remained unknown and our understanding of the PAK4 signaling pathways that affect tumorigenesis is so far sparse. Here we show that PAK4 is overexpressed in breast cancer associated with poor prognosis. PAK4 overexpression abrogates OIS in untransformed human mammary epithelial cells
FigureFigureFigure
Showing 1-2 of 2 papers.
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