PCBP1 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3D12]
$509.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | OTI3D12 |
|---|---|
| Application | IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1-225 of human PCBP1(NP_006187) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA and 50% glycerol |
| Concentration | 0.5 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | HRP |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 37.3 kDa |
| Gene Name | poly(rC) binding protein 1 |
| Database Link | |
| Background | This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. provided by RefSeq, Jul 2008 |
| Synonyms | HEL-S-85; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Pathways | Spliceosome |
Reviews
Documents
| Product Manuals |
| FAQs |
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Resources
Other "OTI3D12" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF806353 | Carrier-free (BSA/glycerol-free) PCBP1 mouse monoclonal antibody, clone OTI3D12 (formerly 3D12) | 100 ug |
$620.00
|
|
| TA806353 | PCBP1 mouse monoclonal antibody, clone OTI3D12 (formerly 3D12) | 100 ul |
$447.00
|
|
| TA806353AM | PCBP1 mouse monoclonal antibody, clone OTI3D12 (formerly 3D12), Biotinylated | 100 ul |
$509.00
|
|
| TA806353S | PCBP1 mouse monoclonal antibody, clone OTI3D12 (formerly 3D12) | 30 ul |
$200.00
|
|
Citations
PCBP1 inhibits the expression of oncogenic STAT3 isoform by targeting alternative splicing of STAT3 exon 23
Wang, Guo, Che et al
Int J Biol Sci (2019) 15 (6), 1177-1186 DOI: 10.7150/ijbs.33103
Wang, Guo, Che et al
Int J Biol Sci (2019) 15 (6), 1177-1186 DOI: 10.7150/ijbs.33103
Cited by 60
AI Summary: In this study, OriGene’s STAT3 cDNA clone (Cat# RC222099) and PCBP1 cDNA clone (Cat# RC200279) were used to overexpress STAT3 and PCBP1 in cells, enabling the authors to investigate the role of PCBP1 in regulating STAT3 alternative splicing and its impact on cancer cell growth.
Showing 1-1 of 1 papers.
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